Clinical Features and Treatment of Ocular Toxoplasmosis

Abstract

Ocular toxoplasmosis is a disease caused by the infection with Toxoplasma gondii through congenital or acquired routes. Once the parasite reaches the retina, it proliferates within host cells followed by rupture of the host cells and invasion into neighboring cells to make primary lesions. Sometimes the restricted parasite by the host immunity in the first scar is activated to infect another lesion nearby the scar. Blurred vision is the main complaint of ocular toxoplasmic patients and can be diagnosed by detection of antibodies or parasite DNA. Ocular toxoplasmosis needs therapy with several combinations of drugs to eliminate the parasite and accompanying inflammation; if not treated it sometimes leads to loss of vision. We describe here clinical features and currently available chemotherapy of ocular toxoplasmosis.

Effect of Nigella sativa oil on experimental toxoplasmosis

“…However, this combined treatment is often associated with bone marrow suppression and kidney problems (Katlama et al 1996). New agents or combination of agents with better therapeutic efficacy and safety than currently available drugs are urgently needed (Park and Nam 2013).…”

Aktuelle Entwicklungen in der Diagnose und Therapie der okulären Toxoplasmose

“…3). Oft wird die aktive Läsion durch hochgradige Vitritis verschleiert und es entsteht das klassische Bild vom «Scheinwerfer im Nebel» [37]. Die Schwere der Uveitis anterior reicht von einer minimalen Reaktion bis hin zu einer intensiven Inflammation, die die Beteiligung des posterioren Segments maskiert.…”

Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis

“…3). Often the active lesion is obscured by severe vitritis producing the classic ‘headlight in the fog' sign [37]. The severity of anterior uveitis may range from minimal reaction to an intense inflammation, masking the posterior segment involvement.…”