Intussusception is defined as a process in which a segment of bowel invaginates into the adjoining intestinal lumen, causing bowel obstruction. It is the most common cause of intestinal obstruction in infants and children between 6 months to 18 months of age. In neonates and premature infants, it accounts for only 3% of intestinal obstruction and 0.3% (0-2.7%) of all cases of intussusception Since neonatal intussusception is an uncommon entity, we conducted this review to examine its occurrence, clinical features, diagnostic modalities, and treatment options.