Clinical Features and Treatment Outcomes of Pulmonary <i>Mycobacterium avium-intracellulare</i> Complex With and Without Coinfections

Wang, Grace; Stapleton, Jack T.; Baker, Arthur W.; Rouphael, Nadine; Creech, C. Buddy; Sahly, Hana M. El; Stout, Jason E.; Jackson, Lisa A.; Charbek, Edward; Leyva, Francisco J.; Tomashek, Kay M.; Tibbals, Melinda; Miller, Aaron S.; Frey, Sharon E.; Niemotka, Samson L.; Wiemken, Timothy; Beydoun, Nour; Alaaeddine, Ghina; Turner, Nicholas; Walter, Emmanuel B.; Chamberland, Robin R.; Abate, Getahun

doi:10.1093/ofid/ofac375

Cited by 2 publications

(1 citation statement)

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“…Furthermore, the compromised airways in NTM-PD patients are more susceptible to secondary infections, and previous studies have indicated that 12% -45% of patients with Mycobacterium avium complex pulmonary disease (MAC-PD) concurrently exhibit bacterial infections [7][8][9] . Although prior investigations have consistently identified co-infection with bacterial pathogens alongside NTM acquisition or disease course, these studies have been limited by the use of sputum culture-based bacterial detection, small numbers of patients, and differences in research objectives and testing timing depending on study design [7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Exploring the Association of Bacterial Coinfections with Clinical Characteristics of Patients with Nontuberculous Mycobacterial Pulmonary Disease

Moon,

Cho,

Shin

2024

Tuberc Respir Dis

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Background: Clinical data for bacterial co-infection of the lower respiratory tract in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD) are scarce. This study aims to assess the prevalence of bacterial co-infection and clinical features in NTM-PD patients.Methods: This retrospective study screened 248 patients with NTM-PD who underwent bronchoscopy between July 2020 and July 2022, from whom newly diagnosed NTM-PD patients were analyzed. Bacterial culture using bronchial washing fluid was performed at the time of NTM-PD diagnosis. Results:In the 180 patients (median age 65 years; 68% female), Mycobacterium avium complex (86%) was the most frequent NTM isolated. Bacterial co-infections were detected in 80 (44%) patients. Among them, the most common bacterium was Klebsiella pneumoniae (n = 25/80, 31.3%), followed by Pseudomonas aeruginosa (n = 20/80, 25%) and Staphylococcus aureus (n = 20/80, 25%). Compared with NTM-PD patients without bacterial co-infections, patients with bacterial co-infections showed more frequent extensive lung involvement (33% vs. 1%, p < 0.001). Additionally, compared with NTM-PD patients without P. aeruginosa infection, those with P. aeruginosa infection were older (74 years vs. 64 years, p = 0.001), had more frequent respiratory symptoms (cough/excessive mucus production 70% vs. 38%, p = 0.008; dyspnea 30% vs. 13%, p = 0.047), and had extensive lung involvement (60% vs. 9%, p < 0.001).Conclusions: Less than half of patients with newly diagnosed NTM-PD had bacterial coinfections, linked to extensive lung involvement. Specifically, P. aeruginosa co-infection was significantly associated with older age, more frequent respiratory symptoms, and extensive lung involvement.

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Section: Introductionmentioning

confidence: 99%

Exploring the Association of Bacterial Coinfections with Clinical Characteristics of Patients with Nontuberculous Mycobacterial Pulmonary Disease

Moon,

Cho,

Shin

2024

Tuberc Respir Dis

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Multiple bacterial culture positivity reflects the severity and prognosis as bronchiectasis in Mycobacterium avium complex pulmonary disease

Ito,

Furuuchi,

Fujiwara

et al. 2023

Respiratory Medicine

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Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Abstract: Coinfections are more common in patients with cystic fibrosis and bronchiectasis. Infiltrates on imaging studies are seen more commonly in patients with coinfections, but coinfections did not affect treatment outcomes of pulmonary Mycobacterium avium complex.

Cited by 2 publications

References 35 publications

Exploring the Association of Bacterial Coinfections with Clinical Characteristics of Patients with Nontuberculous Mycobacterial Pulmonary Disease

Exploring the Association of Bacterial Coinfections with Clinical Characteristics of Patients with Nontuberculous Mycobacterial Pulmonary Disease

Multiple bacterial culture positivity reflects the severity and prognosis as bronchiectasis in Mycobacterium avium complex pulmonary disease

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