Clinical Features, Image Findings, and Prognosis of Inflammatory Pseudotumor of the Liver: A Multicenter Experience of 45 Cases

Abstract

Background/AimsInflammatory pseudotumor (IPT) of the liver is a rare disease characterized by chronic infiltration of inflammatory cells. However, the clinical characteristics and outcomes of IPT remain uncertain.MethodsClinical features, image findings, and outcomes of 55 patients with histologically proven IPT were evaluated.ResultsThey consisted of 26 men and 19 women with median age of 65 years. Serum carcinoembryonal antigen and carbohydrate antigen 19-9 levels were normal in 42 patients (93.3%). Enhanced CT scans indicated poorly defined peripheral enhancement (82.5%) at the arterial phase and poorly defined hyperattenuating lesions with internal hypoattenuating areas at the equilibrium phase (77.0%). Gadolinium-enhancement MRI revealed poorly defined peripheral rim-like enhancement (77.8%). Ten patients underwent surgical resection and 35 were treated conservatively with or without antibiotics. No recurrence was noted after surgical resection during follow-up (1 to 48 months). In all patients who received conservative treatment, complete resolution or size reduction was noted during follow-up (1 to 192 months).ConclusionsCT and MRI provide clues to the diagnosis of IPT in patients with liver masses and normal tumor markers. However, due to the lack of pathognomonic findings, the clinician's suspicion and histological diagnosis are necessary to make an accurate diagnosis of IPT.

A case of hepatic inflammatory pseudotumor protruding from the liver surface

“…According to available data, the male-to-female ratio ranges between 1:1 and 3.5:1, with a male predominance [3]. Patients present with abdominal pain (36-53 %), fever (24-41 %), malaise (11-20 %) and/or weight loss (3-9 %), but sometimes remain asymptomatic (16-20 %) [4,5]. Inflammatory reactions, abnormal liver function tests, or sometimes elevated serum CA19-9 levels may be observed [6,7].…”

Inflammatory pseudotumor of the liver: A case report and literature review

“…IPTL is quite rare and accounts for 8% of extrapulmonary IPTs. The incidence of IPTL is reported to be around 0.7% according to recent studies (14,15). The etiology and pathogenesis of IPTL remain unknown since a variety of tumorous inflammatory lesions lack the features of other IPTs, but IPTL is thought to involve an inflammatory reaction (16).…”

Primary Hepatic Mucosa-Associated Lymphoid Tissue Lymphoma: A Case Report

“…In 1983, Isaacson and Wright (2) initially described MALT lymphomas as a distinctive type of B-cell lymphoma arising in the gastrointestinal tract. MALT lymphomas can be found at mucosal sites such as the stomach, lung, and salivary gland or from sites, which share an embryologic origin with mucosa such as the thyroid that normally lacks organized lymphoid tissue (3).…”