Clinical features may help to identify children and adolescents with greatest risk for thyroid nodules

Allen, Natalie; Desai, Nandini; Song, C.; Yu, Jiahui; Prasad, Uma R.; Francis, Gary L.

doi:10.1007/s40618-019-01176-6

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…39 Interestingly, in a recent report, thyroid nodules were less common in children and adolescents with CAT or high TSH than in their counterparts. 40 The percentage of thyroid nodules with indication for FNAB was higher than expected. 19 This result is in line with other authors' results 41 and suggests that the prevalence of thyroid nodularity in the obese population is probably higher than in the non-obese population.…”

Section: Ta B L E 3 Prevalence Of Thyroid Nodules According To Risk Categoriesmentioning

confidence: 74%

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Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

et al. 2021

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It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost-effective for the early detection and treatment of thyroid cancer. The present study evaluates if this approach can be validated in a real clinical setting.Methods: Patients with obesity who attended hospital-based clinics were evaluated for risk factors of thyroid cancer and ultrasound screened for thyroid nodularity.Detected nodules were evaluated according to current guidelines.Results: A total of 429 patients were evaluated (70.2% women, mean age 49.1 ± 11.0, mean body mass index 42.6 ± 5.8 kg/m 2 ). Risk factors were present in 129 (30.1%) patients. Thyroid nodules with indication for fine-needle aspiration biopsy were detected in 69 (16.1%). We did not find differences in the risk of harbouring thyroid nodules according to the presence of risk factors (no risk factors 16.6%, risk factors 14.1%, P = .64). No single risk factor conferred an increased risk for thyroid nodules During the screening procedure, four cases of thyroid cancer were detected, none of them with the evaluated risk factors. Conclusion:The presence of known risk factors for thyroid cancer does not improve the performance of a US screening strategy aimed at the detection of thyroid nodules in obese patients. According to current guidelines, screening for thyroid nodules in obese patients is not recommended regardless of the presence of thyroid cancer risk factors. What's known• Obesity increases the risk of thyroid cancer • Hypothyroidism and chronic autoimmune thyroiditis are presumed to be risk factors for thyroid cancer • It is unknown whether a thyroid nodule/cancer screening strategy in obese patients could be

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Section: Ta B L E 3 Prevalence Of Thyroid Nodules According To Risk Categoriesmentioning

confidence: 74%

“…In this sense, it has been argued that higher TSH levels in obese patients are not evidence of thyroid dysfunction but, rather, an adaptation process 39 . Interestingly, in a recent report, thyroid nodules were less common in children and adolescents with CAT or high TSH than in their counterparts 40 …”

Section: Discussionmentioning

confidence: 99%

Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

et al. 2021

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“…Furthermore, the prevalence of TN increases over time from 9.3% at diagnosis to 43.9% after 10 years 6 . Allen, et al found that palpation and history could identify some patients with TN, particularly when the gland was small, soft, and asymmetric 19 . However, the prevalence of TN discovered with this approach was much less than in all studies using US.…”

Section: Autoimmune Thyroid Disease Graves' Disease and Goitermentioning

confidence: 99%

Thyroid Nodules in Children and Adolescents: Mini-review

Kerr¹,

Hackman²,

Francis³

2020

j Endocrinol sci

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Insights into Ultrasound Features and Risk Stratification Systems in Pediatric Patients with Thyroid Nodules

Gambale,

Rocha,

Prete

et al. 2024

J. Imaging

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Thyroid nodules in pediatric patients are less common than in adults but show a higher malignancy rate. Accordingly, the management of thyroid nodules in pediatric patients is more complex the younger the patient is, needing careful evaluation by physicians. In adult patients, specific ultrasound (US) features have been associated with an increased risk of malignancy (ROM) in thyroid nodules. Moreover, several US risk stratification systems (RSSs) combining the US features of the nodule were built to define the ROM. RSSs are developed for the adult population and their use has not been fully validated in pediatric patients. This study aimed to evaluate the available data about US features of thyroid nodules in pediatric patients and to provide a summary of the evidence regarding the performance of RSS in predicting malignancy. Moreover, insights into the management of thyroid nodules in pediatric patients will be provided.

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Clinical features may help to identify children and adolescents with greatest risk for thyroid nodules

Cited by 3 publications

References 35 publications

Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

Thyroid Nodules in Children and Adolescents: Mini-review

Insights into Ultrasound Features and Risk Stratification Systems in Pediatric Patients with Thyroid Nodules

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