Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study

Du, Yingzhen; Tu, Lei; Zhu, Pingjun; Mu, Mi; Wang, Runsheng; Yang, Po-Chun; Wang, Xi; Hu, Chao; Ping, Rongyu; Hu, Ping; Li, Tianzhi; Cao, Feng; Chang, Christopher; Hu, Qinyong; Jin, Yang; Xu, Guogang

doi:10.1164/rccm.202003-0543oc

Cited by 801 publications

(603 citation statements)

References 23 publications

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“…Reported illnesses have ranged from mild symptoms to severe illness and death for COVID-19 cases. The majority of COVID-19 infections are mild (80%), some require hospitalization and oxygen therapy (15%), and approximately 5% require intensive care, associated with over 50% mortality [3,4]. DOI: 10.1159/000507898…”

Section: Introductionmentioning

confidence: 99%

Performing Bronchoscopy in Times of the COVID-19 Pandemic: Practice Statement from an International Expert Panel

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Performing Bronchoscopy in Times of the COVID-19 Pandemic: Practice Statement from an International Expert Panel

et al. 2020

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“…The alveolar 94 epithelium is composed of alveolar type 1 cells (AT1s) which line the gas-blood interface 95 and alveolar type 2 cells (AT2s) which produce surfactant to reduce surface tension and 96 protect against pathogens. While SARS-CoV-2 likely infects both the airway and alveolar 97 regions of the lung, it is the damage to the alveolar region that underlines acute respiratory 98 distress syndrome (Du et al, 2020). hallmark of cis-regulatory elements, and can be assayed using techniques such as 106…”

Section: Introduction 78mentioning

confidence: 99%

“…The leading cause of death for COVID-19 is Acute Respiratory Distress Syndrome 251 (ARDS) which is characterized by failure of gas-exchange due to destruction of the 252 alveolar region of the lung (Du et al, 2020). AT2 is an abundant epithelial cell type in the 253 alveolar region and expresses all of the SARS-CoV-2 viral entry genes assayed here and 254 likely bears the brunt of infection.…”

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confidence: 99%

Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

Wang¹,

Chiou

Poirion³

et al. 2020

Preprint

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58Respiratory failure is the leading cause of COVID-19 death and disproportionately 59 impacts adults more than children. Here, we present a large-scale snATAC-seq dataset 60 (90,980 nuclei) of the human lung, generated in parallel with snRNA-seq (46,500 nuclei), 61 from healthy donors of ~30 weeks, ~3 years and ~30 years of age. Focusing on genes 62 implicated in SARS-CoV-2 cell entry, we observed an increase in the proportion of 63 alveolar epithelial cells expressing ACE2 and TMPRSS2 in adult compared to young 64 lungs. Consistent with expression dynamics, 10 chromatin peaks linked to TMPRSS2 65 exhibited significantly increased activity with age and harbored IRF and STAT binding 66 sites. Furthermore, we identified 14 common sequence variants in age-increasing peaks 67 with predicted regulatory function, including several associated with respiratory traits and 68 TMPRSS2 expression. Our findings reveal a plausible contributor to why children are 69 more resistant to COVID-19 and provide an epigenomic basis for transferring this 70 resistance to older populations. 71 72 73 74

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“…Previous studies focused on clinical characteristics and outcomes of COVID-19 patients varied from mild, severe, even deceased cases. 6,7 But the causes and risk factors associated with rapid disease progress to death need to be addressed further. In this study, we aimed to describe the clinical characteristics and outcomes of nonsurvivors confirmed with SARS-CoV-2 infection in the early outbreak, and to analyze the possible risk factors associated with rapid disease progress to death after admission in patients with COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of 101 COVID-19 nonsurvivors in Wuhan, China: a retrospective study

Shi

Zhao

et al. 2020

Preprint

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Background The outbreak of COVID-19 has aroused global concerns. We aimed to describe the clinical characteristics of COVID-19 nonsurvivors and analyze possible causes for the rapid disease progress to death. Methods Patients with confirmed COVID-19 died in Renmin Hospital of Wuhan University before February 15, 2020, were identified. We obtained epidemiological, demographic, and clinical data from electronic medical records. Results Among 101 nonsurvivors, the median age was 71.0 years (IQR, 59.0-80.0), 59.4% were male, 79.2% had one or more comorbidities including hypertension (58.4%), cardiovascular disease (22.8%), diabetes (20.8%) etc. The most common symptoms were fever (76.2%), cough (58.4%) and dyspnea (54.5%). Respiratory failure (99.0%), acute cardiac injury (52.5%), sepsis (40.6%) and acute kidney injury (23.8%) were most common complications. Compared with patients died after 3 days of admission, patients died within 3 days of admission had significantly higher white blood cell count (10.8 vs 6.7*109/L, P=0.001) and neutrophil count (8.9 vs 5.5*109/L, P=0.001), longer prothrombin time (13.2 vs 12.5 s, P=0.040), higher D-dimer concentration (7.64 vs 2.82, P=0.040), higher lactate level (2.9 vs 2.2 mmol/L, P=0.042), lower oxygen saturation (85.0% vs 91.0%, P=0.008), and were more likely to suffer sepsis (52.1% vs 30.2%, P=0.025). Conclusions Older patients with underlying comorbidities suffering COVID-19 were at high risk of death. Respiratory failure, acute cardiac injury and acute kidney injury played crucial roles in the death of COVID-19 patients. Early development of sepsis was associated with the rapid disease progress to death.

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Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study

Cited by 801 publications

References 23 publications

Performing Bronchoscopy in Times of the COVID-19 Pandemic: Practice Statement from an International Expert Panel

Performing Bronchoscopy in Times of the COVID-19 Pandemic: Practice Statement from an International Expert Panel

Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

Clinical characteristics of 101 COVID-19 nonsurvivors in Wuhan, China: a retrospective study

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