Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea: A nationwide, multicenter study

Abstract

Autoimmune hepatitis in Korea is mostly type I, showing a mean age of 53 years with comparable clinical features to other countries. The concordant rate of the two diagnostic criteria was rather low with modest sensitivity of the simplified criteria. Further studies on the validation of the diagnostic criteria are warranted.

Autoimmune hepatitis in adult and pediatric patients: Is there any difference?

“…Overall, the profiles of our patients were consistent to what have been shown in the literature, West and East [1,[3][4][5]. There was a female predominance, advanced disease stage at presentations, presence of other autoimmune disease, response to treatment, and mortality rates.…”

Clinical Presentation, Treatment Outcome and Predictors of Severity in Autoimmune Hepatitis: A Retrospective, Multicenter Experience

“…Similar figures were reported from several studies. Kim and his colleagues reported that 22.7% of their patients had liver cirrhosis at presentation in a cohort of Korean AIH patients [20] . Cirrhosis was more prevalent in AIH patients who presented with jaundice, reaching 50% in one European study [21] and 43% in our series.…”

Population-Based Prevalence, Incidence, and Disease Burden of Autoimmune Hepatitis in South Korea

“…A previous nationwide Korean study reported autoimmune thyroiditis as the most common concurrent autoimmune disease, followed by systemic lupus erythematosus. [24] In this study, we could not confirm the diagnosis of autoimmune thyroiditis; however, thyroid hormone was prescribed in 3.6% of patients with AIH. Therefore, it is conceivable Epidemiology of AIH in South Korea that autoimmune thyroiditis was present in 3.6% or less.…”

“…Previous study also reported that 25% of newly diagnosed patients were not treated. [24] The strength of the present study is its population-based design. The NHI claims data covers > 95% of the entire Korean population.…”