Clinical features of chronic summer-type hypersensitivity pneumonitis and proposition of diagnostic criteria

Onishi, Yasutaka; Kawamura, Tomohiro; Higashino, Takanori; Kagami, Ryogo; Hirata, Nobuya; Miyake, Kohei

doi:10.1016/j.resinv.2019.09.003

Cited by 10 publications

(9 citation statements)

References 28 publications

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“…The mosaic pattern, ground glass opacity, and centrilobular nodules were more common in the chronic HP group than in the IPF group. 15 All the cases (100%) in our cohort presented as a reticular pattern; 87.5% (14/16) had traction bronchiectasis, and 43.75% (7/16) had honeycombing on HRCT scans. Of our cohort, 18.75% (3/16) who had been previously misdiagnosed with tuberculosis had an upper lobe predominant distribution.…”

Section: Discussionmentioning

confidence: 68%

“…However, honeycombing was seen in 29% (9/29) of cases, which was much lower than that seen in IPF cases (100%). The mosaic pattern, ground glass opacity, and centrilobular nodules were more common in the chronic HP group than in the IPF group 15 …”

Section: Discussionmentioning

confidence: 87%

“…The mosaic pattern, ground glass opacity, and centrilobular nodules were more common in the chronic HP group than in the IPF group. 15 …”

Section: Discussionmentioning

confidence: 99%

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Features of transbronchial lung cryobiopsy‐diagnosed fibrotic hypersensitivity pneumonitis

Zhan

Luo

et al. 2022

Clinical Respiratory J

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Background: Hypersensitivity pneumonitis (HP) is a common type among all the interstitial lung diseases, and transbronchial lung cryobiopsy is an alternative diagnostic technique for interstitial lung diseases. In this study, we describe the clinical and pathological features of fibrotic hypersensitivity pneumonitis diagnosed with transbronchial lung cryobiopsy (TBLC). Methods: A total of 46 diffused parenchyma lung disease (DPLD) patients received TBLC were included in this study. Medical records including medical history spirometry examinations, 6-min walk test (6MWT) results, high resolution computed tomographic (HRCT) scans, BAL, and histopathology were collected. Results of HRCT and histopathology were compared and classified, especially.Results: Sixteen patients were diagnosed with fibrotic HP, the mean age of whom was 56.3 AE 12.1 years, and 62.5% of them were male. Three of the 16 patients had been misdiagnosed as tuberculosis and received antituberculosis medications, five patients had been diagnosed as unclassifiable pulmonary Xi Zhan, Yingzhen Du, Jiang Luo, and Yifan Que made equal contributions to this article and they are co-first authors. Hongxia Li, Zhaohui Tong, and Guogang Xu contributed equally.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 87%

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Features of transbronchial lung cryobiopsy‐diagnosed fibrotic hypersensitivity pneumonitis

Zhan

Luo

et al. 2022

Clinical Respiratory J

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“…No case of hypersensitivity pneumonitis with the detection of T. asahii in a humidifier has been described to our knowledge. This yeast is classically found in acute [17] or chronic [18] summer-type HP (the most frequent HP in Japan), which usually occurs during the hot and humid summer period after exposure to mould in wooden houses. It is due to exposure to T. asahii or T. mucoides(formerly T. cutaneum ) [19].…”

Section: Discussionmentioning

confidence: 99%

Hypersensitivity pneumonitis associated with the yeasts Trichosporon asahii and Candida parapsilosis and with humidifier fever.

Soumaré

Kanouté

Cassagnes

et al. 2022

Preprint

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“…Several previous studies have reported biomarkers for differential diagnosis of IPF [5][6][7][8][9] . The majority of the studies evaluated selected genes/proteins with a putative role in the pathology of the ILDs for their efficacy as diagnostic markers, but their diagnostic efficacy has been unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

A novel protein signature from plasma extracellular vesicles for non-invasive differential diagnosis of idiopathic pulmonary fibrosis

Adduri

Cai

et al. 2021

Preprint

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Background: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia of unknown etiology often leading to respiratory failure. Over half of IPF patients present with discordant features of usual interstitial pneumonia on high-resolution computed tomography at diagnosis which warrants surgical lung biopsy to exclude the possibility of other interstitial lung diseases (ILDs). Therefore, there is a need for non-invasive biomarkers for expediting the differential diagnosis of IPF. Methods: Using mass spectrometry, we performed proteomic analysis of plasma extracellular vesicles (EVs) in a cohort of subjects with IPF, chronic hypersensitivity pneumonitis, nonspecific interstitial pneumonitis, and healthy subjects (HS). A five-protein signature was identified by lasso regression and was validated in an independent cohort using ELISA. We evaluated the concordance between plasma EV proteome and the lung transcriptome data. Lastly, we compared the molecular pathways overrepresented in IPF by differentially expressed proteins and transcripts from EVs and lung tissues, respectively. Results: The five-protein signature derived from mass spectrometry data showed area under the receiver operating characteristic curve of 0.915 (95%CI: 0.819-1.011) and 0.958 (95%CI: 0.882-1.034) for differentiating IPF from other ILDs and from HS, respectively. We also found that the EV protein expression profiles mirrored their corresponding mRNA expressions in IPF lungs. Further, we observed an overlap in the EV proteome- and lung mRNA-associated molecular pathways. Conclusions: We discovered a plasma EV-based protein signature for differential diagnosis of IPF and validated this signature in an independent cohort. The signature needs to be tested in large prospective cohorts to establish its clinical utility.

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Clinical features of chronic summer-type hypersensitivity pneumonitis and proposition of diagnostic criteria

Cited by 10 publications

References 28 publications

Features of transbronchial lung cryobiopsy‐diagnosed fibrotic hypersensitivity pneumonitis

Features of transbronchial lung cryobiopsy‐diagnosed fibrotic hypersensitivity pneumonitis

Hypersensitivity pneumonitis associated with the yeasts Trichosporon asahii and Candida parapsilosis and with humidifier fever.

A novel protein signature from plasma extracellular vesicles for non-invasive differential diagnosis of idiopathic pulmonary fibrosis

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