Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution

Yang, Zhijun; Wang, Zhenmin; Zhou, Qiangyi; Li, Shiwei; Wang, Xingchao; Wang, Bo; Zhao, Fei

doi:10.1007/s00701-015-2635-x

Cited by 34 publications

(21 citation statements)

References 36 publications

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“…The duration of time is relatively short, varying from 2 to 48 months (median, 3 months). Second, different from the common meningiomas with a women predominance, [21,22] CPA cystic meningiomas prefer to occur in young patients (median age 27.5 years), and no gender predominance was found. Third, in regards to the radiological features, the size of the cystic meningioma in CPA is relatively large, with a median largest diameter of 50 mm (range 30–60 mm).…”

Section: Discussionmentioning

confidence: 98%

A case report on cystic meningioma in cerebellopontine angle and recommendations for management

Wang

et al. 2018

Medicine

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Rationale:Cystic meningioma located at the cerebellopontine angle (CPA) is an extremely rare occurrence. It is frequently misdiagnosed preoperatively. Little is known about the clinical features and outcome of this rare disease.Patient concerns:A 70-year-old male presenting with progressive headache and gait disturbance.Diagnosis:According to the symptoms, signs, and Gd-enhanced magnetic resonance images (MRI), a preoperative diagnosis of hemangioblastoma located in left CPA was made. Finally, the histological examination revealed a meningioma.Interventions:A complete resection, including the part of the solid mass together with cyst, was performed.Outcomes:The postoperative course of the patient was uneventful, and no residual or recurrent tumor was found during the 24-month follow-up period.Lessons:Cystic meningioma should be included in the differential diagnosis of a CPA mass with atypical radiologic features, such as a large cyst and enhanced mural nodule. By summarizing the related literature, we found that the most common pathological subtype of CPA cystic meningioma is the clear cell subtype, which belongs to WHO grade II. Gross total resection including the enhanced cyst wall is extremely important. A close follow-up is necessary because of the high recurrence rate in this subset of meningioma.

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Section: Discussionmentioning

confidence: 98%

A case report on cystic meningioma in cerebellopontine angle and recommendations for management

Wang

et al. 2018

Medicine

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“…IL-6 is a cell-derived cytokine that plays an important role in the body’s inflammatory response and cellular immunity, which can play a dual role in protecting and damaging the central nervous system [ 13 , 14 ]. CRP, a sensitive acute-phase protein synthesized by human liver, has important immunoregulation effects, including stimulating the tissue factor expression of monocytes and macrophages, and increasing the motion and activity of macrophages, which can reflect the degree of inflammatory response in the body [ 15 ]. The load of HHV-8, a major pathogenic factor of MCD, is related to the condition of MCD, and HHV-8 can encode the virus-derived IL-6 during replication, accelerating the onset of disease [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Clinical Characteristics, Pathological Changes and Changes of Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Children with Castleman’s Disease

Zou

Pan

et al. 2020

Med Sci Monit

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Background The aim of this study was to analyze the pathological changes, clinical characteristics and changes in immunity, interleukin-6 (IL-6) and C-reactive protein (CRP) in children with Castleman’s disease (CD). Material/Methods A total of 15 CD child patients were enrolled as observation group, while 20 normal children receiving healthy examination were enrolled as healthy control group. The pathological changes, clinical characteristics and changes in immunity and serum IL-6 and CRP expressions were retrospectively analyzed in observation group. Results The clinical manifestation of unicentric CD (UCD) was mainly enlargement of cervical lymph nodes without liver-spleen enlargement and fever, and the major pathological type was the hyaline-vascular type. Multicentric CD (MCD) child patients all had anemia, fever and other systemic symptoms, and the major pathological type was the plasma-cell type. There were expressions of the immune indexes, including cluster of differentiation 3 (CD3), CD4, CD8, CD20, and CD79, in a certain degree, while CD138 and VS38C expressions displayed the polyclonal proliferation of plasma cells, rather than neoplastic proliferation. The Epstein-Barr virus and human herpes virus-8 detection results were negative, and CD21 in follicular dendritic cells in abnormal germinal center was positive. The expression levels of serum IL-6 and CRP in observation group were higher than those in control group ( P <0.05). Conclusions There are immune dysfunction and increased expressions of serum IL-6 and CRP in child patients with CD, so it can be speculated that the immune abnormality and overexpression of serum inflammatory factors may be associated with the occurrence of CD.

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“…The secretory subtype is classical in this location, associated with a higher rate of peritumoral edema and seizures [19,25]. Clear-cell meningioma could also be encountered in Meckel's cave and the petroclival region, often mimicking schwannoma, with a predilection for young women and with an aggressive pattern [26][27][28].…”

Section: Neuropathologymentioning

confidence: 98%

Parasellar Meningiomas

Graillon¹,

Régis²,

Barlier³

et al. 2020

Neuroendocrinology

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Parasellar spaces remain particularly singular, comprising the most important neurovascular structures such as the internal carotid artery and optic, oculomotor, and trigeminal nerves. Meningiomas are one of the most frequent tumors arising from parasellar spaces. In this location, meningiomas remain mostly benign tumors with WHO grade I and a meningothelial subtype. Progestin intake should be investigated and leads mostly to conservative strategies. In the case of benign nonsymptomatic tumors, observation should be proposed. Tumor growth will lead to the proposition of surgery or radiosurgery. In the case of an uncertain diagnosis and an aggressive pattern, a precise diagnosis is required. For cavernous sinus and Meckel's cave lesions, complete removal is rarely considered, leading to the proposition of an endoscopic endonasal or transcranial biopsy. Optic nerve decompression could also be proposed via these approaches. A case-by-case discussion about the best approach is recommended. A transcranial approach remains necessary for tumor removal in most cases. Vascular injury could lead to severe complications. Cerebrospinal fluid leakage, meningitis, venous sacrifice, visual impairment, and cranial nerve palsies are more frequent complications. Pituitary dysfunctions are rare in preoperative assessment and in postoperative follow-up but should be assessed in the case of meningiomas located close to the pituitary axis. Long-term follow-up is required given the frequent incomplete tumor removal and the risk of delayed recurrence. Radiosurgery is relevant for small and well-limited meningiomas or intra-cavernous sinus postoperative residue, whereas radiation therapy and proton beam therapy are indicated for large, extended, nonoperable meningiomas. The place of the peptide receptor radionuclide therapy needs to be defined. Targeted therapy should be considered in rare, recurrent, and aggressive parasellar meningiomas.

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Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution

Abstract: The proportion of CCM in spinal meningiomas is likely to be much larger than that in intracranial meningiomas. CCMs should be resected totally when possible to decrease the risk of recurrence or prolong patient's PFS time.

Cited by 34 publications

References 36 publications

A case report on cystic meningioma in cerebellopontine angle and recommendations for management

A case report on cystic meningioma in cerebellopontine angle and recommendations for management

Analysis of Clinical Characteristics, Pathological Changes and Changes of Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Children with Castleman’s Disease

Parasellar Meningiomas

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