Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration

Okubo, Akiko; Hirakawa, Mayumi; Ito, Mizuho; Sameshima, M; Sakamoto, Taiji

doi:10.1007/s00417-007-0680-8

Cited by 29 publications

(16 citation statements)

References 24 publications

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“…In the second group, neither feeder nor draining vessels are detectable, and the number of network vessels is small. Okubo et al 4 also reported that PCV can be divided into two types; the small-short and large-long types, but the clinical features in their report differed from those described by our group. They defined the small-short type as having small lesions and a short period of disturbed vision.…”

contrasting

confidence: 82%

Associations of Complement Factor H (CFH) and Age-Related Maculopathy Susceptibility 2 (ARMS2) Genotypes with Subtypes of Polypoidal Choroidal Vasculopathy

Takada¹,

Nakayama

Mori³

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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contrasting

confidence: 82%

Associations of Complement Factor H (CFH) and Age-Related Maculopathy Susceptibility 2 (ARMS2) Genotypes with Subtypes of Polypoidal Choroidal Vasculopathy

Takada¹,

Nakayama

Mori³

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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“…However, those cases are often difficult to distinguish from tAMD. The variations of PCV in its presentation may be only due to the stage of the disease (more progressed disease should have larger lesions) [56], but evidence is accumulating which supports the existence of subtypes in PCV.…”

Section: Angiographic Imagingmentioning

confidence: 99%

Polypoidal Choroidal Vasculopathy: Clinical Features and Genetic Predisposition

2013

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Polypoidal choroidal vasculopathy (PCV) is currently recognized as a phenotype of age-related macular degeneration (AMD). PCV is believed to be a type of choroidal neovascularization, although some cases of PCV show a distinct vascular abnormality of the choroidal vessels. PCV often shows several unique clinical manifestations which are apparently different from typical neovascular AMD (tAMD). In addition, the natural course and response to treatment are often different between tAMD and PCV. Moreover, recent genetic studies suggested a possible difference in the genetic susceptibility to disease between tAMD and PCV, as well as the existence of heterogeneity among PCV cases. In viewing the accumulation of knowledge about PCV, we have summarized the recent literature regarding PCV in this review article to improve the understanding of this clinical entity including possible susceptibility genes. We will also discuss the optimal treatment strategies for PCV in accordance with the results of recent clinical and genetic studies.

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“…Okubo et al reported that PCV can be divided into two types; the small-short and large-long types, but the clinical features in their report differed from those described by our group [20]. Miki et al recently advocated dividing PCV into polypoidal lesions with a clear branching vascular network and polypoidal lesions without such a vascular network [21].…”

Section: Introductionmentioning

confidence: 80%

Associations of complement factor B and complement component 2 genotypes with subtypes of polypoidal choroidal vasculopathy

et al. 2014

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BackgroundWe previously reported on subtypes of polypoidal choroidal vasculopathy (PCV), and categorized PCV as polypoidal choroidal neovascularization (CNV) and typical PCV. The aim of this study was to clarify whether complement component 2 (C2) and complement factor B (CFB) genotypes are associated with subtypes of polypoidal choroidal vasculopathy, such as polypoidal CNV and typical PCV.MethodsFirst, we categorized 677 patients into typical age-related macular degeneration (tAMD; 250 patients), PCV (376) and retinal angiomatous proliferation (RAP; 51). Second, we categorized 282 patients with PCV as having polypoidal CNV (84 patients) or typical PCV (198) based on indocyanine green angiographic findings. In total, 274 subjects without AMD, such as PCV and CNV, served as controls. A SNP (rs547154) in the C2 gene and three SNPs (rs541862, rs2072633, rs4151667) in the CFB gene were genotyped, and case–control studies were performed in subjects with these PCV subtypes.ResultsIn tAMD, no SNPs were associated with allele distributions. In PCV, rs547154 and rs2072633 were associated with allele distributions. RAP was only associated with rs2072633. After logistic regression analysis with adjustment for confounding factors, tAMD, PCV and RAP were found to be associated with rs2072633.As to PCV subtypes, there were significant differences in the distributions of rs547154, rs541862 and rs2072633 in the case–control studies for polypoidal CNV, but not between the typical PCV and control groups. Logistic regression analysis with adjustment for confounding factors showed the distributions of rs547154, rs541862 and rs2072633 to differ significantly between the controls and polypoidal CNV cases and that these SNPs were protective. The A/A genotype of rs2072633 was significantly more common in the polypoidal CNV than in the typical PCV group (p = 0.03), even with adjustment for polyp number and greatest linear dimension.ConclusionsPCV might be genetically divisible into polypoidal CNV and typical PCV. The C2 and CFB gene variants were shown to be associated with polypoidal CNV. Typical PCV was not associated with variants in these genes.

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Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration

Cited by 29 publications

References 24 publications

Associations of Complement Factor H (CFH) and Age-Related Maculopathy Susceptibility 2 (ARMS2) Genotypes with Subtypes of Polypoidal Choroidal Vasculopathy

Associations of Complement Factor H (CFH) and Age-Related Maculopathy Susceptibility 2 (ARMS2) Genotypes with Subtypes of Polypoidal Choroidal Vasculopathy

Polypoidal Choroidal Vasculopathy: Clinical Features and Genetic Predisposition

Associations of complement factor B and complement component 2 genotypes with subtypes of polypoidal choroidal vasculopathy

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