Clinical features of elderly-onset Adult-onset Still’s disease

Elderly-onset adult Still’s disease

“…Another recent Japanese study demonstrated that EOSD (> 60 years old) patients less often had typical skin rashes and sore throat and more often had pleuritis than AOSD [4].…”

“…Among 74 articles resulting from the search, 43 were finally selected for the review (41 case reports [3, and 2 case series [4,45]) (Fig. 1).…”

“…Adult-onset Still's disease (AOSD) is a rare inflammatory disorder of unknown etiology with an estimated prevalence of 1 to 10 cases per million [1,2]. It usually affects young patients between 16 and 35 years old, but some cases of elderly patients have been reported [3][4][5][6][7]. AOSD clinical presentation includes four main symptoms: spiking fever, arthralgia or arthritis, skin rash and leukocytosis ≥ 10,000 cells/µl with neutrophils ≥ 80%.…”

“…An elevation in the total and glycosylated ferritin levels is suggestive of AOSD but is not pathognomonic [2]. Many other manifestations are possible, making diagnosis challenging, especially in the elderly [3,4]. Several features have been found to be associated with this category of patients with a higher frequency of complications and poor survival [3,4].…”

“…Many other manifestations are possible, making diagnosis challenging, especially in the elderly [3,4]. Several features have been found to be associated with this category of patients with a higher frequency of complications and poor survival [3,4]. However, the number of elderly-onset Still's disease (EOSD) cases remains insufficient to explore their clinical features.…”