Clinical features of Escherichia coli pneumonia

Okimoto, Niro; Hayashi, Toshikiyo; Ishiga, Mitsunori; Nanba, Fumiyo; Kishimoto, Michihiro; Yagi, Shinichi; Kurihara, Takeyuki; Asaoka, Naoko; Tamada, Sadao

doi:10.1007/s10156-010-0034-z

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…At least 4 studies have specifically evaluated the role of E. coli as an etiologic agent of CAP [ 19–22 ]. The reported prevalence of culture-positive E. coli pneumonia based on a few published studies evaluating culture-positive CAP ranges from 3.5% to 12% [ 4–6 , 18 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology and Outcomes of Community-Acquired Escherichia coli Pneumonia

John

Deshpande

Brizendine

et al. 2021

Open Forum Infectious Diseases

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Objective To describe the epidemiology, risk factors and outcomes of community-acquired Escherichia coli pneumonia in comparison to other gram-negative and pneumococcal pneumonias. Methods E.coli is an under recognized cause of bacterial community-acquired pneumonia (CAP). We conducted a large retrospective cohort study of adult patients admitted with pneumonia to 173 US hospitals included in Premier Research database from July 2010–June 2015. Patients were included if they had principal diagnosis code for pneumonia, or a principal diagnosis of respiratory failure or sepsis with secondary diagnosis of pneumonia and had a positive blood or respiratory culture obtained on hospital day 1. The primary outcome was in-hospital case fatality. Secondary outcomes included intensive care unit (ICU) admission, invasive mechanical ventilation (IMV) and use of vasopressors. Results Of 8,680 patients with pneumonia and positive blood or respiratory cultures, 1,029 (7.7%) had E.coli CAP. Patients with E.coli pneumonia were older and more likely to have a principal diagnosis of sepsis. Patients with E.coli pneumonia had significantly higher case fatality than patients with pneumococcal pneumonia (adjusted odds ratio, 1.55 [95% CI, 1.23–1.97]) but not significantly different than other gram-negative pneumonias (adjusted odds ratio, 1.06 [95% CI, 0.85–1.32]). Approximately 36% of the isolates were resistant to fluoroquinolones; 9.3% were resistant to ceftriaxone. Conclusions E.coli is an important cause of severe CAP; with higher mortality than pneumococcal pneumonia but similar to other gram-negative pneumonias. The rate of fluoroquinolone resistance was high and empiric fluoroquinolones should be used with caution in these patients.

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Section: Discussionmentioning

confidence: 99%

“…In the present study, E. coli accounted for ~8% of all culture-positive cases. Higher rates have been observed in elderly patients and those with severe pneumonia [ 19 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Outcomes of Community-Acquired Escherichia coli Pneumonia

John

Deshpande

Brizendine

et al. 2021

Open Forum Infectious Diseases

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“…E. coli has been repeatedly observed as a particular cause of pneumonia in elderly patients, frequently following aspiration (26)(27)(28). Transtracheal aspiration is common in neurologically impaired elderly.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Risk Factors, and Mortality for Ventilator-Associated Pneumonia in Middle-Aged, Old, and Very Old Critically Ill Patients*

Blot

Koulenti

Dimοpoulos

et al. 2014

Critical Care Medicine

158

111

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“…E. coli is an uncommon respiratory pathogen, but can cause respiratory tract infections in the elderly and those with compromised immunity. 29 According to previous studies, E. coli pneumonia was associated with comorbidities such as diabetes mellitus, cerebrovascular disease, and chronic lung diseases. 29 , 30 In this study of patients with AECOPD, E. coli was not a common causative agent, but it was significantly more prevalent in patients with bronchiectasis, interstitial lung disease, and diabetes mellitus.…”

Section: Discussionmentioning

confidence: 97%

The Relationship Between Comorbidities and Microbiologic Findings in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Seo¹,

Sim²,

Min³

et al. 2022

COPD

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Purpose Data regarding the relationship between microbiologic features and comorbidities in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are limited. The aim of this study was to correlate microbiologic findings with comorbidities in patients with moderate to severe AECOPD. Patients and Methods This multicenter observational study included patients with AECOPD seen at 28 hospitals in South Korea between January 2015 and December 2018, and the data were retrospectively collected. Pathogens were examined in patients with either pulmonary or extrapulmonary comorbidities, and compared to those of patients without comorbidities. The relationship between pathogen type and the number of comorbidities was also evaluated. Results Bacterial infections (178 [37.2%] vs 203 [28.7%], p = 0.002) and co-infections with bacteria and viruses (65 [13.6%] vs 57 [8.1%], p = 0.002) were more prevalent in patients with pulmonary comorbidities. Bacterial pathogens (280 [34.7%] vs 101 [26.7%], p=0.006) were detected at a higher rate in patients with extrapulmonary comorbidities. Previous pulmonary tuberculosis (PTB), bronchiectasis, and diabetes mellitus were risk factors for bacterial infection, and congestive heart failure was a risk factor for bacterial and viral co-infection. As the number of comorbidities increased, the risk of bacterial infection increased considerably. Pseudomonas aeruginosa was more frequently identified in patients with previous PTB (57 [15.3%] vs 59 [7.4%], p < 0.001) and bronchiectasis (33 [19.6%] vs 83 [8.3%], p < 0.001). Conclusion AECOPD patients with comorbidities were more likely to experience infection-related exacerbations compared to those without comorbidities. As the overall number of comorbidities increased, the risk of bacterial infection increased significantly.

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Clinical features of Escherichia coli pneumonia

Cited by 8 publications

References 10 publications

Epidemiology and Outcomes of Community-Acquired Escherichia coli Pneumonia

Epidemiology and Outcomes of Community-Acquired Escherichia coli Pneumonia

Prevalence, Risk Factors, and Mortality for Ventilator-Associated Pneumonia in Middle-Aged, Old, and Very Old Critically Ill Patients*

The Relationship Between Comorbidities and Microbiologic Findings in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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