Clinical features of hematopoietic malignancies and related disorders among benzene-exposed workers in China. Benzene Study Group.

Linet, Martha S.; Yin, Shu; Travis, Lois B.; Li, C Y; Zhang, Z N; Li, D G; Rothman, Nathaniel; Li, G L; Chow, WH; Donaldson, Jennifer A; Dosemeci, Mustafa; Wacholder, Sholom; Blot, William J.; Hayes, Richard B.

doi:10.1289/ehp.961041353

Cited by 26 publications

(6 citation statements)

References 85 publications

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“…Occupational exposure to benzene and other solvents is one of the most consistently observed risk factors for myeloid malignancy . The International Agency for Research on Cancer (IARC) has determined that benzene exposure is carcinogenic to the bone marrow and causes both AML and MDS, with several potential mechanistic explanations for this association .…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, a recent update from petroleum industry workers in Australia, Canada and the United Kingdom reported a significant association between benzene and MDS but not AML in workers exposed to lower doses of benzene, suggesting that MDS may be the more relevant outcome for current employees . A long‐standing cohort study of occupational benzene exposure in China has also documented increased risks of MDS/AML in benzene exposed workers, with the most recent report showing similar elevated risks in males and females and across different occupations after 28 years of follow‐up . Several studies in the general population have also shown associations between benzene and MDS and AML .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population‐based study

Poynter

Richardson

Roesler

et al. 2016

Intl Journal of Cancer

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Benzene exposure is one of the few well-established risk factors for myeloid malignancy. Exposure to other chemicals has been inconsistently associated with hematologic malignancies. We evaluated occupational and residential chemical exposures as risk factors for AML and MDS using population-based data. AML and MDS cases were identified by the Minnesota Cancer Surveillance System. Controls were identified through the Minnesota driver’s license/identification card list. Chemical exposures were measured by self-report. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CI). We included 265 MDS cases, 420 AML cases, and 1388 controls. We observed significant associations between both MDS and AML and benzene (OR=1.77, 95% CI 1.19, 2.63 and OR=2.10, 95% CI 1.35, 3.28, respectively) and vinyl chlorides (OR=2.05, 95% CI 1.15, 3.63 and OR=2.81, 95% CI 1.14, 6.92). Exposure to soot, creosote, inks, dyes and tanning solutions, and coal dust were associated with AML (range ORs=2.68–4.03), while no association was seen between these exposures and MDS (range ORs=0.57–1.68). Pesticides and agricultural chemicals were not significantly associated with AML or MDS. Similar results were observed in analyses stratified by sex. In addition to providing risk estimates for benzene from a population-based sample, we also identified a number of other occupational and residential chemicals that were significantly associated with AML; however, all exposures were reported by only a small percentage of cases (≤10%). While chemical exposures play a clear role in the etiology of myeloid malignancy, these exposures do not account for the majority of cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population‐based study

Poynter

Richardson

Roesler

et al. 2016

Intl Journal of Cancer

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“…Information was abstracted onto standardized forms by physician‐investigators blinded to benzene exposure status of the patients. For suspected diagnoses of HLD, all abstracted forms, medical records, and available hematopathologic laboratory data and slides were reviewed systematically by expert Chinese and US hematopathologists . HLD cases were coded using the ninth edition of the International Classification of Diseases (ICD‐9) for mortality and a modification of ICD‐9 that reflected key elements of the third edition of the ICD for Oncology .…”

Section: Methodsmentioning

confidence: 99%

“…For suspected diagnoses of HLD, all abstracted forms, medical records, and available hematopathologic laboratory data and slides were reviewed systematically by expert Chinese and US hematopathologists. 24 HLD cases were coded using the ninth edition of the International Classification of Diseases (ICD-9) for mortality 25 and a modification of ICD-9 that reflected key elements of the third edition of the ICD for Oncology. 26 For all exposed and unexposed workers with lung cancer as the underlying or contributory cause of death, the diagnostic materials were evaluated systematically by expert oncologists and pathologists.…”

Section: Ascertainment and Validation Of Hld And Lung Cancer Diagnosesmentioning

confidence: 99%

A retrospective cohort study of cause‐specific mortality and incidence of hematopoietic malignancies in Chinese benzene‐exposed workers

Linet

Yin

Gilbert

et al. 2015

Intl Journal of Cancer

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Benzene exposure has been causally linked with acute myeloid leukemia (AML), but inconsistently associated with other hematopoietic, lymphoproliferative and related disorders (HLD) or solid tumors in humans. Many neoplasms have been described in experimental animals exposed to benzene. We used Poisson regression to estimate adjusted relative risks (RR) and the likelihood ratio statistic to derive confidence intervals for cause-specific mortality and HLD incidence in 73,789 benzene-exposed compared with 34,504 unexposed workers in a retrospective cohort study in 12 cities in China. Follow-up and outcome assessment was based on factory, medical and other records. Benzene-exposed workers experienced increased risks for all-cause mortality (RR 5 1.1, 95% CI 5 1.1, 1.2) due to excesses of all neoplasms (RR 5 1.3, 95% CI 5 1.2, 1.4), respiratory diseases (RR 5 1.7, 95% CI 5 1.2, 2.3) and diseases of blood forming organs (RR 5 ', 95% CI 5 3.4, '). Lung cancer mortality was significantly elevated (RR 5 1.5, 95% CI 5 1.2, 1.9) with similar RRs for males and females, based on threefold more cases than in our previous follow-up. Significantly elevated incidence of all myeloid disorders reflected excesses of myelodysplastic syndrome/acute myeloid leukemia (RR 5 2.7, 95% CI 5 1.2, 6.6) and chronic myeloid leukemia (RR 5 2.5, 95% CI 5 0.8, 11), and increases of all lymphoid disorders included excesses of non-Hodgkin lymphoma (RR 5 3.9, 95%CI 5 1.5, 13) and all lymphoid leukemia (RR 5 5.4, 95%CI 5 1.0, 99). The 28-year follow-up of Chinese benzene-exposed workers demonstrated increased risks of a broad range of myeloid and lymphoid neoplasms, lung cancer, and respiratory diseases and suggested possible associations with other malignant and non-malignant disorders.

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“…The bone marrow histopathology of T-MDS more often shows multilineage dysplasia, fibrosis and hypoplasia than is observed in de novo forms of MDS making comparable classification difficult along guidelines designed for de novo MDS [ 12 , 13 ]. This seems particularly true of examples of secondary MDS consequent to excessive occupational exposures to benzene, an obsolete chemotherapy drug [ 2 , 14 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Temozolomide-Induced Myelodysplasia

Natelson

Pyatt²

2010

Advances in Hematology

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A patient who had received temozolomide (TMZ) as a single agent in treatment of malignant glioma developed therapy-induced myelodysplasia (T-MDS). TMZ is an orally active imidazotetrazine which methylates guanine residues in DNA, ultimately causing single and double-strand DNA breaks leading to apoptotic cell death. TMZ does not chemically cross-link DNA and is considered a nonclassical alkylating agent, similar in structure and activity to dacarbazine. Observations on this patient, and on similarly treated others, suggest that the cumulative dose threshold (CDT) for TMZ that predisposes to T-MDS and which may potentially lead to acute myeloid leukemia (T-AML) is around 18000 to 20000 mg/sq m. Although the incidence of T-MDS and the predisposing CDT of TMZ may differ from that of other potentially leukemogenic compounds currently and formerly used as chemotherapeutic agents, all alkylating agents, including TMZ, should be considered potentially leukemogenic when administered long term.

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Clinical features of hematopoietic malignancies and related disorders among benzene-exposed workers in China. Benzene Study Group.

Abstract: Previous occupational cohort studies of benzene-exposed workers have for the most 1353-1364 (1996)

Cited by 26 publications

References 85 publications

Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population‐based study

Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population‐based study

A retrospective cohort study of cause‐specific mortality and incidence of hematopoietic malignancies in Chinese benzene‐exposed workers

Temozolomide-Induced Myelodysplasia

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