Clinical Features of Hepatitis

Regev, Arie; Schiff, Eugene R.

doi:10.1002/9780470987131.ch3

Cited by 10 publications

(8 citation statements)

References 170 publications

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“…In recent years there have been two main treatment options for patients with chronic HBV infection, interferon (IFN)‐ α and lamivudine. Both agents are beneficial in a proportion of patients; however, IFN α is associated with dose‐limiting adverse effects and must be given parenterally, while treatment with lamivudine often gives rise to resistant mutants 1, 2…”

mentioning

confidence: 99%

Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma

Chen

Liu

Zhu

et al. 2005

Rapid Comm Mass Spectrometry

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To investigate the pharmacokinetics of adefovir as an anti-hepatitis B virus drug, a sensitive and specific liquid chromatography/tandem mass spectrometry method was developed and validated. After a simple protein precipitation using methanol, the post-treatment samples were analyzed on a C(18) column interfaced with a triple-quadrupole tandem mass spectrometer using positive electrospray ionization. A structural analogue, PMPA, was used as the internal standard. The method was linear in the concentration range 0.25-100 ng/mL. The lower limit of quantification was 0.25 ng/mL. The intra- and inter-day relative standard deviation over the entire concentration range was 5.7% or less. The accuracy determined at three concentrations (0.75, 10 and 80 ng/mL for adefovir) was within +/-2.5% relative error. The method described here was successfully applied for the evaluation of pharmacokinetic profiles of adefovir after single oral administration doses of 5, 10 and 20 mg adefovir dipivoxil to ten healthy volunteers.

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mentioning

confidence: 99%

Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma

Chen

Liu

Zhu

et al. 2005

Rapid Comm Mass Spectrometry

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“…It can often result in both acute and chronic hepatitis. For these reasons, intensive research has focused on treatment during the past three decades 1. Currently, only a few drugs are available for the clinical treatment of HBV infection, including α‐interferon (IFN‐α) and a series of nucleoside analogues such as lamivudine (3‐TC), adefovir dipivoxyl, and entecavir (Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Anti‐Hepatitis B Virus Activity of a Novel Class of Thiazolylbenzimidazole Derivatives

Luo

Yao

et al. 2010

Archiv der Pharmazie

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Recently, heterocyclic benzimidazole derivatives have been investigated and validated as a promising class of antiviral agents. In this paper, a series of novel thiazolylbenzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity on the HepG2.2.15 cell line. Afterwards, the preliminary structure-activity relationship (SAR) was discussed. Compound 8b, with IC(50) = 1.1 µM and SI > 90.9, was the most promising compound and could be selected as a benchmark compound for further investigation.

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“…Children commonly presents with prodrome followed by icteric phase with or without cholestatic features followed by complete resolution in most cases in 8-10 weeks period. 4 HAV is common in pediatric population and it spread through feco-oral route. Symptomatic and supportive care is mainstay of management of AVH.…”

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confidence: 99%

Old dietary cultural practices leading to suboptimal nutritional intake of calories in children with acute viral hepatitis

Bharti

Neelu

2020

Int J Contemp Pediatr

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Background: Acute viral hepatitis (AVH) is one of the common infections in developing nation. Hepatotrophic virus causes AVH and most of the time it has self-limiting course. HAV is most common cause of AVH. Suboptimal dietary cultural practices are common in our nation. This study was done to know the impact of suboptimal dietary practices done in AVH.Methods: Observational study conducted with 50 children with AVH. Dietary assessment was done at three point of time. First During AVH, second, pre illness and then two weeks after nutritional counselling. Data of dietary modification done by parents/caregiver during AVH recorded. History of herbal medicine taken for treatment of AVH enquired.Results: HAV positive was (72%), HEV positivity was in 8 (16%) cases, hepatitis B was positive in 4 (8%) children and dual infection HAV+HEV was detected in 2 (4%) children. Many parents did dietary modification due to AVH and also by some local treating physicians, 18 (36%) patients were also on herbal medication for treatment of AVH. During AVH the mean calorie and protein requirement decreased from 96% to 54% and 92% to 43% respectively. Two weeks after nutritional counseling the mean calorie and protein intake increased from 54% to 88% and 43% to 84% respectively. This change in calorie and protein was statistically significant (p<0.01) Non-vegetarian diet preference was restarted in many of them after nutritional counseling.Conclusions: This observational study revealed that suboptimal dietary cultural practices are prevalent in India. Majority of children were on bland diet and receiving inadequate proteins and calories.

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Clinical Features of Hepatitis

Cited by 10 publications

References 170 publications

Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma

Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma

Synthesis and Anti‐Hepatitis B Virus Activity of a Novel Class of Thiazolylbenzimidazole Derivatives

Old dietary cultural practices leading to suboptimal nutritional intake of calories in children with acute viral hepatitis

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