Clinical features of incidental mild cognitive impairment and dementia in a population‐based study

Hishikawa, Nozomi; Fukui, Yoshio; Sato, Kota; Yamashita, Toru; Ohta, Yasuyuki; Abe, Kōji

doi:10.1111/ggi.12778

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Therefore, we considered this age group as pre-elderly and recruited them into the study. The present study revealed the prevalence of MCI to be 28.8% which is in contrast to the study on incidental MCI that had a prevalence of 13.5% (Hishikawa et al, 2017).…”

Section: Demographic Data Analysiscontrasting

confidence: 99%

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Association between altered serum lipids levels on cognitive impairment in the pre-elderly and elderly population of South India

Menge

Nair

Nagendra

et al. 2020

ijrps

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Altered serum lipid levels are linked with varying degrees of cognitive impairment due to various mechanisms. In addition, the prevalence of mild cognitive impairment varies substantially from one region to another. The prevalence of cognitive impairment in relation to altered serum lipid levels on cognitive impairment in the pre-elderly and elderly population is of great importance. Therefore, it is important to characterize the features of mild cognitive impairment with respect to altered lipid profile. This study investigated the association between altered serum lipid levels on cognitive impairment in the pre-elderly and elderly population. The present cross-sectional study was done in 406 pre-elderly and elderly patients. The participants were subjected to demographic data collection followed by Mini-Mental State Examination (MMSE). Participants were classified into two groups: cognitively-normal (n=289) and mild cognitive impairment (117). Fasting serum lipids of the participants was estimated using venous blood samples by standard biochemical techniques. Differences in the lipid concentrations between the two groups were then compared using the Mann-Whitney U test. Significant differences were found in MMSE scores between the cognitively-normal and MCI groups (p<0.05). MCI patients had a significantly lower level of high-density lipoprotein when compared to cognitively-normal participants (p<0.05). In addition, the two groups showed differences in education levels attained. The cognitively-normal group had a greater number of educational years when compared to the MCI group. The study found significant differences in serum lipid concentrations between the cognitively-normal individuals and the mild cognitive impairment group. Future investigations may be needed to explore the effects exerted by lipids on cognitive functions.

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Section: Demographic Data Analysiscontrasting

confidence: 99%

“…Participants in this study were relatively younger compared to a similar study (Hishikawa et al, 2017). Even though most studies on cognitive impairment are conducted in people aged 65 years or older, we recruited patients aged 55 years and above.…”

Section: Demographic Data Analysismentioning

confidence: 99%

Association between altered serum lipids levels on cognitive impairment in the pre-elderly and elderly population of South India

Menge

Nair

Nagendra

et al. 2020

ijrps

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“…For example, vascular dysfunction may be associated with progression of both amyloid and τ pathology (51). In patients already diagnosed with Alzheimer’s disease dementia and mild cognitive impairment, both cognitive and affective dysfunction were increased among those with insulin resistance (52,53), and treating vascular risk factors helped to slow cognitive decline (54). The strong association between type 2 diabetes and vascular contributions to dementia should be carefully considered when implementing treatment and prevention measures.…”

Section: Toward a Precision Medicine Model For Dementia: Type 2 Diabementioning

confidence: 99%

Type 2 Diabetes, Cognition, and Dementia in Older Adults: Toward a Precision Health Approach

et al. 2016

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IN BRIEF There has been a concurrent dramatic rise in type 2 diabetes and dementia in the United States, and type 2 diabetes shares common genetic and environmental risk factors and underlying pathology with both vascular and Alzheimer’s dementias. Given the ability to identify this at-risk population and a variety of potential targeted treatments, type 2 diabetes represents a promising focus for a precision health approach to reduce the impact of cognitive decline and dementia in older adults.

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Cognitive and affective functions associated with insomnia: a population-based study

Hishikawa

Fukui

Sato

et al. 2017

Neurological Research

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Clinical features of incidental mild cognitive impairment and dementia in a population‐based study

Cited by 5 publications

References 28 publications

Association between altered serum lipids levels on cognitive impairment in the pre-elderly and elderly population of South India

Association between altered serum lipids levels on cognitive impairment in the pre-elderly and elderly population of South India

Type 2 Diabetes, Cognition, and Dementia in Older Adults: Toward a Precision Health Approach

Cognitive and affective functions associated with insomnia: a population-based study

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