Clinical features of Japanese patients with gastrointestinal <scp>long‐COVID</scp> symptoms

Yagi, Kazuma; Asakura, Takanori; Terai, Hideki; Ohgino, Keiko; Masaki, Katsunori; Namkoong, Ho; Chubachi, Shotaro; Miyata, Jun; Kawada, Ichiro; Kodama, Nobuhiro; Sakamoto, Satoshi; Umeda, Akira; Ishiguro, Takashi; Ishii, Makoto; Fukunaga, Koichi

doi:10.1002/jgh3.13006

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…However, existing studies emphasize the high specificity of diarrhea, taste, and smell disorders at onset for COVID-19. [35][36][37][38] Another report suggests a correlation between taste and smell disorders and diarrhea. 39 Although few risk factors for sore throat as long COVID have been studied in detail, [40][41][42] myalgia, arthralgia, and diarrhea during hospitalization may be risk factors.…”

Section: Discussionmentioning

confidence: 99%

Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study

Okada,

Ishida,

Kanzaki

et al. 2024

OTO Open

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ObjectiveThis study aimed to investigate the clinical features of long COVID cases presenting with upper respiratory symptoms, a topic not yet fully elucidated.Study DesignProspective cohort study.SettingA multicenter study involving 26 medical facilities in Japan.MethodsInclusion criteria were patients aged ≥18 years old with a confirmed COVID‐19 diagnosis via severe acute respiratory syndrome coronavirus 2 polymerase chain reaction or antigen testing, who were hospitalized at the participating medical facilities. Analyzing clinical information and patient‐reported outcomes from 1009 patients were analyzed. The outcome measured the degree of initial symptoms for taste or olfactory disorders and assessed the likelihood of these symptoms persisting as long COVID, as well as the impact on quality of life if the upper respiratory symptoms persisted as long COVID.ResultsPatients with high albumin, low C‐reactive protein, and low lactate dehydrogenase in laboratory tests tended to experience taste or olfactory disorders as part of long COVID. Those with severe initial symptoms had a higher risk of experiencing residual symptoms at 3 months, with an odds ratio of 2.933 (95% confidence interval [CI], 1.282‐6.526) for taste disorders and 3.534 (95% CI, 1.382‐9.009) for olfactory disorders. Presence of upper respiratory symptoms consistently resulted in lower quality of life scores.ConclusionThe findings from this cohort study suggest that severe taste or olfactory disorders as early COVID‐19 symptoms correlate with an increased likelihood of persistent symptoms in those disorders as long COVID.

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Section: Discussionmentioning

confidence: 99%

Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study

Okada,

Ishida,

Kanzaki

et al. 2024

OTO Open

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“…Abdominal pain (6.7-41%) can be localized or diffuse, often linked to altered gut motility [120,121,[124][125][126][127].…”

Section: Gastrointestinal Manifestationsmentioning

confidence: 99%

Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Calcaterra,

Zanelli,

Foppiani

et al. 2024

Diseases

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Long COVID affects both children and adults, including subjects who experienced severe, mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive overview of the incidence, clinical characteristics, risk factors, and outcomes of persistent COVID-19 symptoms in both children and adults, encompassing vulnerable populations, such as pregnant women and oncological patients. Our objective is to emphasize the critical significance of adopting an integrated approach for the early detection and appropriate management of long COVID. The incidence and severity of long COVID symptoms can have a significant impact on the quality of life of patients and the course of disease in the case of pre-existing pathologies. Particularly, in fragile and vulnerable patients, the presence of PASC is related to significantly worse survival, independent from pre-existing vulnerabilities and treatment. It is important try to achieve an early recognition and management. Various mechanisms are implicated, resulting in a wide range of clinical presentations. Understanding the specific mechanisms and risk factors involved in long COVID is crucial for tailoring effective interventions and support strategies. Management approaches involve comprehensive biopsychosocial assessments and treatment of symptoms and comorbidities, such as autonomic dysfunction, as well as multidisciplinary rehabilitation. The overall course of long COVID is one of gradual improvement, with recovery observed in the majority, though not all, of patients. As the research on long-COVID continues to evolve, ongoing studies are likely to shed more light on the intricate relationship between chronic diseases, such as oncological status, cardiovascular diseases, psychiatric disorders, and the persistent effects of SARS-CoV-2 infection. This information could guide healthcare providers, researchers, and policymakers in developing targeted interventions.

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Gastrointestinal manifestations of long COVID

King

2024

Life Sciences

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Clinical features of Japanese patients with gastrointestinal long‐COVID symptoms

Cited by 3 publications

References 11 publications

Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study

Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study

Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Gastrointestinal manifestations of long COVID

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