Clinical features of lung cancer in patients with connective tissue diseases: A 10-year hospital based study

Adzic, Tatjana; Pešut, Dragica; Nagorni-Obradović, Ljudmila; Stojšić, Jelena; Vasiljevic, Mladenko; Bouros, Demosthenes

doi:10.1016/j.rmed.2007.10.022

Cited by 38 publications

(27 citation statements)

References 22 publications

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“…The higher incidence of lung cancer in patients with connective tissue diseases and the changes in smoking habits should be recognised [22,23]. We were unable to collect smoking habits data for 20 years period.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data

Kontakiotis

Manolakoglou

Zoglopitis

et al. 2016

Monaldi Arch Chest Dis

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Background and Aim. The relative frequency of histological subtypes of lung cancer in Europe has changed dramatically during the 20th century. The aim of this study was to explore the changing epidemiology of lung cancer in Northern Greece over the last two decades. Methods. From the extensive database of the Bronchoscopy Unit of the G. Papanicolaou General Hospital, Thessaloniki, Greece, we identified all patients with a histologic and/or cytologic report positive for lung cancer over two consecutive decades. Results. Between 1/1/1986 and 31/12/2005 we identified 9981 patients with specimens positive for lung cancer. A significant increase in mean patient age was observed during the second decade (64.8±9.4 vs. 62.1±8.9, p=0.001). Men developed lung cancer ten times more often than women. The predominant histological type was squamous cell cancer in males (4203 cases, 45.7%) and adenocarcinoma (418 cases, 52.6%) in females. The number of lung cancer cases was significantly higher during the second decade compared to the first decade (5766 cases [57.8%] vs. 4215 cases [42.2%], respectively, p<0.001). There was a significant decrease in the percentage of squamous cell carcinoma in males in the second decade (2317 cases [44.1%] vs. 1886 cases [48.0%], p<0.001), and an increase in adenocarcinoma (1021 cases [19.4%] vs. 609 [11.6%], p<0.001). In females, the relative incidence of adenocarcinoma was decreased and that of squamous cell carcinoma was increased, but not significantly. There was no obvious change in the incidence of small cell lung cancer. Neoplastic lesions were most often located in the upper lobes. Conclusion. The number of lung cancer cases has increased in the last decade. Squamous lung cancer appears to be decreasing in men and increasing in women. Adenocarcinoma appears to be increasing in men and decreasing in women. There appears to be no change in small cell lung cancer. During the second decade there has been a significant decrease in the male: female ratio.

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Section: Discussionmentioning

confidence: 99%

Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data

Kontakiotis

Manolakoglou

Zoglopitis

et al. 2016

Monaldi Arch Chest Dis

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“…The causes of lymphopenia in cancer patients may vary. It may result in part from the destruction of lymphocytes by the tumor, and/or from impaired differentiation of lymphocyte progenitors [23]. Peripheral blood lymphopenia is a recognized predictor of poor survival in patients with advanced cancer, attributed to the fundamental role of lymphocytes in cell-mediated immunity with the destruction of host cancer cells [24].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors in Patients Presenting with Pleural Effusion Revealing Malignancy

et al. 2014

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Background: The survival of patients with malignant pleural effusion is considered generally poor. Most of the studies reporting results of prognostic factors are retrospective, using pleural thoracentesis for diagnosis. The objectives of our study were to reveal possible prognostic factors in patients initially presenting with undiagnosed pleural effusion proven to be malignant by diagnostic thoracoscopy. Methods: Ninety consecutive patients, 48 of whom were male (53%), with a median age of 69 years (range 37-93) and a performance status (PS) of 0/1 (63%) and with initially undiagnosed pleural effusion that was proven to be malignant by thoracoscopy were evaluated. Survival time was defined as the time from thoracoscopic diagnosis to death or the last follow-up. A regression analysis was used to determine significant clinical and biological prognostic factors. Results: Lung carcinoma (44.4%), breast carcinoma (24.4%), and mesothelioma (12.2%) were the most frequent tumors diagnosed. The median overall survival was 11 months (range 0.5-55). The survival of the patients was related to the following factors: histology of the primary tumor (p = 0.008), PS (p < 0.001), white blood cells (p = 0.018), and the blood neutrophil-to-lymphocyte (N/L) ratio (p = 0.002). Multiple regression showed PS, histology, and the N/L ratio. Conclusion: The factors affecting survival in our patients were PS, primary tumor histology, and the N/L ratio. These factors may help physicians select patients for treatment and/or interventional procedures.

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“…The present case has progressed at an advanced stage of lung cancer when diagnosed. Adžić et al reported that majority of patients who complicated with lung cancer in connective tissue disease (CTD) also presented at an advanced stage of lung cancer with 87% having stage III or IV disease [13] . And they also proposed that the necessity of making efforts for earlier recognition of lung cancer in patients with CTD with regular follow-up, including chest imaging.…”

Section: Discussionmentioning

confidence: 99%

A case of IgG4-related interstitial lung disease showing usual interstitial pneumonia pattern: Unusual case for histological features with pathological proof

Sato

Hashimoto

Tobiume

et al. 2014

CRCP

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The case was a 71-years-old male with chest abnormal shadow and persistent dry cough. Chest CT showed ground-glass opacities, traction bronchiectasis, and honeycomb-like change in the bilateral lower lobes. Laboratory tests revealed high serum IgG4 concentration. Pathological examination of the video-assisted thoracoscopic surgery biopsy taken from the right lung showed a pattern compatible with usual interstitial pneumonia (UIP) with strong infiltration of IgG4-positive plasma cells. Based on these findings, diagnosis of IgG4-related interstitial lung disease (ILD) was made. One year later, when ILD was progressed with the appearance of swelling of both submandibular glands, treatment with prednisolone (PSL) was started. When the dose of PSL was tapered to 7.5 mg, left pleural effusion emerged in chest CT. Further examination yielded the diagnosis of lung adenocarcinoma and he was treated with chemotherapy. After two cycles of chemotherapy, IgG4-related interstitial lung disease exacerbated, thus he was re-treated with moderate dose of PSL. Response to PSL treatment was good, but unfortunately, chemotherapy for lung cancer was discontinued due to the risk for re-exacerbation of ILD. To our knowledge, this is the eighth case of IgG4-related ILD ever reported and the second case diagnosed as UIP pattern pathologically.

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Clinical features of lung cancer in patients with connective tissue diseases: A 10-year hospital based study

Abstract: The majority of CTD patients who developed LC were diagnosed at advanced stage and had poor survival. Efforts for early detection of LC in CTD patients' group are warranted.

Cited by 38 publications

References 22 publications

Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data

Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data

Prognostic Factors in Patients Presenting with Pleural Effusion Revealing Malignancy

A case of IgG4-related interstitial lung disease showing usual interstitial pneumonia pattern: Unusual case for histological features with pathological proof

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