Clinical features of multiple primary carcinomas of the oral cavity

Abstract

Abstract. The present study aimed to elucidate the clinical characteristics of multiple primary carcinomas of the oral cavity. The clinical records of 1,024 patients who were treated during follow-up for oral cancer at the Department of Stomatology, Henan Provincial People's Hospital, between March 2013 and December 2014 were retrospectively reviewed. The clinical characteristics of 961 patients who developed single primary oral squamous cell carcinoma (SCC) during follow-up and 54 patients who subsequently developed multiple primary carcinomas in the oral cavity were compared. Multiple primary carcinomas exhibited a female predilection, were most prevalent in the gingiva, and tended to show earlier tumor and nodal stages, as compared with single primary carcinomas. The local recurrence rate was higher for multiple primary carcinomas, as compared with single primary carcinomas, and was demonstrated to increase with the number of multiple primary occurrences. The cumulative incidence rates for metachronous second primary carcinomas following the onset of the first carcinoma at 10 years was 8.0%. Recurrence of multiple primary carcinomas did not decrease the survival rates of the patients assessed in the present study. Furthermore, differences were detected in the clinical characteristics between patients with single oral SCC and those with multiple primary oral carcinomas. The results of the present study indicated that early diagnosis and treatment and close long-term follow-up are required for patients with multiple primary oral carcinomas.

Occurrence of quadruple squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation for leukemia: A case report

“…The risk factors for MPCs in patients with head and neck cancer include an older age, being male, and smoking and alcohol consumption (16). In addition, it has been reported that MPCs most frequently occurred in the keratinized epithelium, such as the gingiva and hard palate (17), which is consistent with the findings in the present case study. However, the patient of the present study had no history of smoking, or alcohol or betel nut use, which suggested that other risk factors may be involved.…”

Bilateral simultaneous primary Oral Squamous Cell Carcinoma: A rare presentation

“…Presence of multiple primary tumours doesn't affect the overall survival as compared to the single primary cancer. In a study conducted by Ya-Dong Li et all it was reported that the disease specific survival rate for multiple primary tumours was reported to be 90.7% and 79.6% at 5 years and 10 years respectively [ 10 ].…”

Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers

“…However, the survival was poorer in patients with MPTs that occurred in the esophagus or lung in a nationwide study (24). The incidence of multiple primary tumors varies in every patient with HNC (3,25,26). Although a regular follow-up CT was arranged after treatment of these patients, some patients with hypopharyngeal and esophageal cancers were still diagnosed in a late tumor stage.…”