Clinical Features of Ocular Sarcoidosis in Patients with Biopsy-proven Pulmonary Sarcoidosis in Serbia

Radosavljević, Aleksandra; Jakšić, Vesna; Pezo, Lato; Kovačević-Pavićević, Dragana; Ilić, Aleksandra; Vučinić, Violeta

doi:10.3109/09273948.2016.1167224

Cited by 21 publications

(22 citation statements)

References 23 publications

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“…3 The severity of systemic involvement is not associated with the development of OS. 11,13,35,108 Only one study, to our knowledge, reports on a higher incidence of advanced stages of pulmonary sarcoidosis in patients with uveitis. 109 So far, there are no specific extraocular manifestations of sarcoidosis identified that show relationship with ocular involvement.…”

Section: Relation Between Ocular and Systemic Sarcoidosesmentioning

confidence: 99%

Ocular Involvement in Sarcoidosis

Groen

Rothová

2017

Semin Respir Crit Care Med

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Ocular involvement in sarcoidosis occurs in ∼40% and the eye is the presenting organ in roughly 20%. The course of ocular disease does not necessarily parallel that of systemic disease. Uveitis is the most common presentation and shows mainly a chronic course; anterior uveitis is associated with better visual prognosis than posterior localization. Painful bilateral anterior granulomatous uveitis most commonly occurs in black patients at younger age, while painless posterior bilateral involvement with peripheral multifocal choroiditis is commonly seen in elderly white females. Patients with posterior uveitis develop often ocular complications and central nervous system involvement. Vitritis, segmental periphlebitis, choroidal granulomas, and peripheral multifocal chorioretinitis are often seen clinical features. Optic nerve involvement is uncommon, but if present, results often in poor visual outcome. Lacrimal gland and conjunctival involvement are also common and present clinically as dry eyes or remain asymptomatic with good visual prognosis. Sarcoidosis-associated uveitis is mostly managed by local treatment with steroid drops or periocular and intraocular steroid injections or with novel intraocular corticosteroid implants. Patients with sight-threatening disease or optic nerve involvement need systemic therapy. Systemic therapy is based on a step-up regimen where corticosteroids are used in the initial phase of the disease and if long-term treatment is required, steroid-sparing immunomodulatory drugs are implemented such as methotrexate or biological agents. Despite the mainly chronic course, need for long-term treatment, and frequent ocular surgeries in the majority of patients, the visual outcome of sarcoidosis-associated uveitis is fairly good if therapy has started on time.

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Section: Relation Between Ocular and Systemic Sarcoidosesmentioning

confidence: 99%

Ocular Involvement in Sarcoidosis

Groen

Rothová

2017

Semin Respir Crit Care Med

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“…Pulmonary sarcoidosis in Serbian patients is most often followed by ocular sarcoidosis, as the first most common site of extrapulmonary sarcoid manifestations [52]. Some clinical features of these patients differ from those in other European populations, with more common neuro-ophthalmologic lesions [52].…”

Section: Missense Variants Frequent In the Serbian Population Sample:mentioning

confidence: 99%

The first insight into the genetic structure of the population of modern Serbia

Drljaca

Zukić

Kovačević

et al. 2020

Preprint

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The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever dataset of variants in clinically relevant genes in the population sample of contemporary Serbia. A few variants significantly more frequent in the analyzed sample population compared to the European population as a whole are distinguished as its unique genetic determinants. We explored thoroughly their potential functional impact and its correlation with the health burden of the population of Serbia. Our variant’s catalogue improves the understanding of genetics of modern Serbia, contributes to application of precision medicine and health equity. In addition, this resource may also be applicable in neighboring regions and in worldwide functional analyses of genetic variants in individuals of European descent.

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“…Uveitis can lead to visually significant complications such as cataract, glaucoma, retinal vasculitis, vitreous opacities and macular edema. [1]…”

Section: Introductionmentioning

confidence: 99%

“…[16] Females (76%) are more likely to develop ocular involvement compared to males (24%) in a study with biopsy-proven systemic sarcoidosis. [1]…”

Section: Introductionmentioning

confidence: 99%

“…One report from Serbia with 88 biopsy-proven sarcoidosis showed 32 patients (36.4% of all) manifested ocular sarcoidosis. [1] Posterior uveitis was the most common (15.9%), followed by neuro-ophthalmologic manifestations (9.1%), conjunctival lesions (7.9%), panuveitis (5.7%), eyelid skin lesions (2.3%), orbital inflammation (2.3%), anterior uveitis (2.3%), and intermediate uveitis (1.1%). Complications included cataract (20.4%), glaucoma (5.7%), cystoid macular edema (3.4%), epiretinal membrane formation (4.5%); macular atrophy (2.3%), and choroidal neovascularization (1.1%).…”

Section: Introductionmentioning

confidence: 99%

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Ocular sarcoidosis

Yang

Salek²,

Rosenbaum

2017

Current Opinion in Pulmonary Medicine

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Purpose of review Ocular involvement in sarcoidosis is present in up to 80 percent of patients and is frequently manifested before diagnosis of the underlying systemic disease. Considering the therapeutic consequences, early diagnosis of the underlying disease is advantageous in patients presenting with ocular inflammation. There are several ocular findings suggestive of underlying sarcoidosis, such as granulomatous keratic precipitates, iris nodules, cells in the vitreous humor known as snowballs and snowbanks, and retinal periphlebitis. High suspicion is crucial for the diagnosis of sarcoidosis. This review on ocular sarcoidosis will mainly focus on new diagnostic and treatment modalities. Recent findings Recent studies found possible new diagnostic indicators for the diagnosis of ocular sarcoidosis which include not only serum profiles but also vitreous sample analysis. Ophthalmologic imaging techniques have improved to investigate the ocular structure in detail. Results from recent uveitis clinical trials have included sarcoidosis as an underlying cause and have reported positive results. Summary The diagnosis of ocular sarcoidosis can be challenging in some cases. High suspicion is important to diagnose ocular sarcoidosis with various laboratory and ophthalmic tools. There are many possible options for the treatment of ocular sarcoidosis including various biologic agents.

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Clinical Features of Ocular Sarcoidosis in Patients with Biopsy-proven Pulmonary Sarcoidosis in Serbia

Abstract: Patients in Serbia demonstrated ocular sarcoidosis as the first most common site of extrapulmonary sarcoid manifestations, with more often neuro-ophthalmologic lesions than in other European populations.

Cited by 21 publications

References 23 publications

Ocular Involvement in Sarcoidosis

Ocular Involvement in Sarcoidosis

The first insight into the genetic structure of the population of modern Serbia

Ocular sarcoidosis

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