Clinical features of patients with candidemia in sepsis

Komori, Akira; Abe, Toshikazu; Kushimoto, Shigeki; Ogura, Hiroshi; Shiraishi, Atsushi; Deshpande, Gautam A.; Saitoh, Daizoh; Fujishima, Seitaro; Mayumi, Toshihiko; Gando, Satoshi

doi:10.1002/jgf2.250

Cited by 1 publication

(2 citation statements)

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“…These balls are most likely the result of haematogenous seeding from septic arthritis of the knee joint [20]. This highlights the high mortality associated with candidemia derived from Candida bone and joint diseases [21,22,31]. However, these results must be interpreted cautiously, particularly when there is a difference of only one individual.…”

Section: Discussionmentioning

confidence: 99%

“…This type of PJI poses a challenge for clinicians and requires a multidisciplinary approach, including systemic antibiotics, local therapies, and surgery [18][19][20]. The systemic and prophylactic treatment of PJIs may be ineffective, as antimicrobials are incapable of reaching the prosthesis-tissue interface due to the continued presence of necrotic and/or avascular tissue after surgery [21].…”

Section: Introductionmentioning

confidence: 99%

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A New Antifungal-Loaded Sol-Gel Can Prevent Candida albicans Prosthetic Joint Infection

et al. 2021

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Fungal PJI is one of the most feared complications after arthroplasty. Although a rare finding, its high associated morbidity and mortality makes it an important object of study. The most frequent species causing fungal PJI is C. albicans. New technology to treat this type of PJI involves organic–inorganic sol-gels loaded with antifungals, as proposed in this study, in which anidulafungin is associated with organophosphates. This study aimed to evaluate the efficacy of an anidulafungin-loaded organic–inorganic sol-gel in preventing prosthetic joint infection (PJI), caused by Candida albicans using an in vivo murine model that evaluates many different variables. Fifty percent (3/6) of mice in the C. albicans-infected, non-coated, chemical-polished (CP)-implant group had positive culture and 100% of the animals in the C. albicans-infected, anidulafungin-loaded, sol-gel coated (CP+A)-implant group had a negative culture (0/6) (p = 0.023). Taking the microbiology and pathology results into account, 54.5% (6/11) of C. albicans-infected CP-implant mice were diagnosed with a PJI, whilst only 9.1% (1/11) of C. albicans-infected CP+A-implant mice were PJI-positive (p = 0.011). No differences were observed between the bone mineral content and bone mineral density of noninfected CP and noninfected CP+A (p = 0.835, and p = 0.181, respectively). No histological or histochemical differences were found in the tissue area occupied by the implant among CP and CP+A. Only 2 of the 6 behavioural variables evaluated exhibited changes during the study: limping and piloerection. In conclusion, the anidulafungin-loaded sol-gel coating showed an excellent antifungal response in vivo and can prevent PJI due to C. albicans in this experimental model.

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