Clinical features of patients with Myasthenia gravis from the Henan province, China

Gao, Feng; Zhao, Xue; Zhang, Jing; Cui, Xin; Zhang, Yingna; Li, Qianru; Li, Pingping; Fang, Hua; Du, Ying; Zhang, Qingyong; Yang, Jing; Zhang, Yunke

doi:10.1002/mus.24920

Cited by 11 publications

(13 citation statements)

References 37 publications

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“… reported a peak incidence in women at 30–40 years old and men at 60–70 years old. There is significant variation in the male‐to‐female ratio in MG in western countries (1:1.41–1:2.03); the gender ratio in our study was 1:1.23 , similar to previous reports in China (1.15–1:1.17) .…”

Section: Resultssupporting

confidence: 90%

“…Prognosis of AChR‐MG was not correlated with the antibody level. In our previous studies, the disease severity for patients with AChR‐MG was not correlated with the antibody level, indicating that a high antibody level is insufficient to predict the severity of symptoms and prognosis . It is not clear if LRP4‐MG has similar characteristics; further studies with expanded samples are needed.…”

Section: Resultsmentioning

confidence: 89%

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Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis

Han

Zhang

et al. 2019

Euro J of Neurology

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Background and purpose Low‐density‐lipoprotein‐receptor‐associated protein 4 (LRP4) autoantibodies have recently been detected in myasthenia gravis (MG), but little is known about the clinical characteristics associated with this serological type. In this study, the clinical features of Chinese patients with anti‐LRP4 antibody‐positive MG were characterized. Methods A total of 2172 MG serum samples were collected from patients in various parts of China. An enzyme‐linked immunosorbent assay was used to detect acetylcholine receptor (AChR) antibody and titin antibody, and cell‐based assays were used to detect muscle‐specific kinase antibody and LRP4 antibody. Clinical data for patients with MG were collected from different provinces in China. Results In total, 16 (0.8%) patients with LRP4‐MG were found amongst 2172 total patients, including three patients with AChR/LRP4‐MG. Additionally, 13 (2.9%) patients with LRP4‐MG were found amongst 455 patients with double seronegative MG. The ratio of males to females for these 13 patients was 1:1.6, and 53.8% patients were children. A total of 91.7% of cases exhibited initial ocular involvement, and 58.3% of cases exhibited simple eye muscle involvement. Responses to acetylcholinesterase inhibitors and prednisone were observed. Conclusion The expanded sample confirmed that the positive rate of LRP4 antibodies in China is lower than that in western countries. Our results highlighted the differences between LRP4‐MG and other antibody groups. Children and female patients with LRP4‐MG have a higher prevalence, often involving the ocular muscles and limb muscles. The clinical symptoms are mild, and satisfactory responses to treatment are often achieved.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 89%

Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis

Han

Zhang

et al. 2019

Euro J of Neurology

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“…Our result was similar to the studies of India, China, Sri Lanka. 4,5,24,21 Zang et al has reported 58% of ocular myasthenia in their study. 24 Our patients were only followed for few months after diagnosis.…”

Section: Discussionmentioning

confidence: 76%

“…4 Mechanical intubation was needed in about 17.4% which is quite high, in comparison to other previous studies. 5,21 Previous studies have shown the association of MG with autoimmune diseases of thyroid disorders, hyperthyroidism being common. 3,5 In contrast to this, our study showed hypothyroidism was common among MG patients (9 patients; 39.1%) whereas only 1 patient (4.3%) was found to have hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile of Patients with Myasthenia Gravis in a Tertiary Center of Nepal

Ojha¹,

Oli²,

Gajurel³

et al. 2017

Nep J Neurosci

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Myasthenia gravis (MG) has a cosmopolitan distribution and can affect people of all age group. Sometimes atypical presentation causes difficulty in the early diagnosis and management. Our aim is to study the clinical subtypes and manifestations of MG along with serological and electrophysiological diagnostic methods. Patients who were admitted in Neurology department or presented in Neurology outpatient department of Tribhuvan University Teaching Hospital from 2015 March to 2016 November were retrospectively reviewed. Out of 28 patients reviewed, 23 patients were included in the study. Their mean age of onset was 40.4±19.2 years; range=12 – 78 years, and 12 of them were female (52.2%). Eight patients (34.8%) were diagnosed with ocular myasthenia and 15 were patients (65.2%) of General Myasthenia. Seventeen patients (73.9%) were acetylcholine receptor (AChR) antibodies positive, one female patient was found to be muscle specific kinase (MuSK) positive. Decremental pattern in Repetitive Nerve stimulation (RNS) was reported in 11 patients (47.8%) and ice pack test was positive in 16 patients (69.3%). Ophthalmological findings are the most common presentation of MG patients. Icepack test is an easy clinical diagnostic tool for outpatient department which has both high sensitivity and specificity. RNS and antibody tests are the supporting tests useful for confirming the diagnosis.Nepal Journal of Neuroscience, Volume 14, Number 1, 2017, Page: 14-17

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“…It has been suggested that the severity of weakness in myasthenia gravis depends on the functional activities of the antibodies (in www.jmscr.igmpublication. (3,4) . MG in the Asian population may be clinically different from that in Caucasians (5,6) .…”

Section: Introductionmentioning

confidence: 99%

Clinical-Immunological Profile of Myasthenia Gravis-A Tertiary Care Centre Experience

Chithra¹

2017

jmscr

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Clinical features of patients with Myasthenia gravis from the Henan province, China

Abstract: These differences are likely related to geographical, environmental, and ethnic differences. Understanding these differences will help us to define more specific treatment.

Cited by 11 publications

References 37 publications

Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis

Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis

Clinical Profile of Patients with Myasthenia Gravis in a Tertiary Center of Nepal

Clinical-Immunological Profile of Myasthenia Gravis-A Tertiary Care Centre Experience

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