Clinical features of pulmonary cryptococcosis in thin-section CT in immunocompetent and non-AIDS immunocompromised patients

Sui, Xin; Huang, Yao; Song, Wei; Zheng, Fuling; Wang, Xiao; Xu, Xiaoli; Wang, Zixing; Jiang, Jinmei; Jin, Zhengyu

doi:10.1007/s11547-019-01088-8

Cited by 26 publications

(31 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characteristics of chest CT findings in PC has been well described in the literature [ 13 , 14 ]. The radiological presentations of PC varied from a solitary pulmonary nodule or mass, multiple nodules, lobular, segmental or subsegmental consolidation, to bronchopneumonia [ 1 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The radiological presentations of PC varied from a solitary pulmonary nodule or mass, multiple nodules, lobular, segmental or subsegmental consolidation, to bronchopneumonia [ 1 , 6 ]. Several studies reported that single nodule pattern [ 6 , 9 , 13 , 15 ] and peripheral distribution of lesions [ 3 , 6 , 8 , 11 , 16 ] were the most common pulmonary CT findings. These observations were supported by our study, which showed that the single nodule pattern was the most commonly identified radiological pattern (33 out of 39, 84.6%) and that most lesions (38 out of 47, 80.9%) were located in the peripheral lung field.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

Ren

Xiao

et al. 2021

BMC Pulm Med

View full text Add to dashboard Cite

Background We characterized the clinical features, radiographic characteristics, and response to treatment of immunocompetent and immunocompromised patients with pulmonary cryptococcosis (PC). Methods We retrospectively reviewed the medical records and radiological profiles of patients diagnosed with PC who received surgical resection between May 2015 and November 2020 in a tertiary referral center. Results A total of 21 males and 18 females were included in the study. 23 patients were immunocompetent and 20 out of the 39 were asymptomatic. Immunocompetent patients were diagnosed with PC at a younger age than immunocompromised patients (48.9 vs 57.1 years, P = 0.02). Single nodule pattern was the most frequent lesion pattern (33 out of 39, 84.6%) and right upper lobe was the most common site of location (15 out of 47, 31.9%). The majority of lesions were located peripherally (38 out of 47, 80.9%) and most lesions were 1–2 cm in diameter (30 out of 47, 63.8%). Cavitation was more likely to occur in immunocompromised patients (5 out of 11, 45.5%) than in immunocompetent patients (6 out of 36, 16.7%) (P = 0.04) and there was complete resolution of PC in all patients treated with anti-fungal therapy. Conclusions Immunocompetent patients were diagnosed with PC at a younger age than immunocompromised patients. Single nodule pattern was the most frequent lesion pattern in PC patients. Cavitation was more likely to occur in immunocompromised patients than in immunocompetent patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

Ren

Xiao

et al. 2021

BMC Pulm Med

View full text Add to dashboard Cite

show abstract

“…There were approximately 225,000 new cryptococcal meningitis cases occur globally each year with significant mortality, especially among acquired immune deficiency syndrome (AIDS) patients 1 . Cryptococcus is widely distributed in nature and can be found in bird droppings, soil and decaying wood 2 . The respiratory tract is the primary portal for cryptococcal invasion, pulmonary cryptococcosis (PC) may occur after inhalation of Cryptococcus spores 3 .…”

mentioning

confidence: 99%

Clinical analysis in immunocompetent and immunocompromised patients with pulmonary cryptococcosis in western China

Zhang

Yang

et al. 2020

Sci Rep

View full text Add to dashboard Cite

cryptococcosis is a systemic infection and it may occur in immunocompromised and immunocompetent hosts. In order to better understand the clinical characteristics of patients with PC in different immune status, we retrospectively investigated the clinical, radiological, and treatment profiles of immunocompetent and immunocompromised patients with PC during a 10-year period (2008-2017). As a result, out of 136 patients, 94 (69.1%) were immunocompromised hosts. For the PC patients without CNS involvement, higher percentage of immunocompetent patients (39.5%, 15/38) had asymptomatic presentation than immunocompromised patients (6.3%, 3/48) (P < 0.05). Multiple pulmonary nodules (72.7%, 56/77), ground-glass attenuation/interstitial changes (94.4%, 17/18) and cavitation (88.6%, 31/35) were significantly frequent in immunocompromised patients (P < 0.05). A total of 47 patients were misdiagnosed as tuberculosis or tumors based on ct signs. pc was likely to be misdiagnosed as tuberculosis in immunocompromised patients (88.2%, 15/17), and tumor was more likely to be considered in immunocompetent patients (43.3%, 13/30). Immunocompetent patients accounted for 80% (24/30) of patients with definite diagnosis on surgical lung biopsy. Fluconazole monotherapy can achieve good clinical outcome in most PC patients without central nervous system (CNS) involvement (91.5%, 54/59). After 3 months of treatment, 92.7% (38/41) patients have improved imaging findings. In conclusion, pc has diverse imaging manifestations and it is easily misdiagnosed. Lobectomy should be carefully selected in immunocompetent patients with a single lung lesion. Fluconazole monotherapy is preferred for pc patients without cnS involvement.

show abstract

“…Radiology examinations, specifically computed tomography and plain radiography, are essential to assess lung disorders. [28][29][30][31][32] This is crucial in COVID-19 management, particularly to assess the extension of lung parenchymal involvement. However, radiology research has also investigated the role of both imaging modalities as screening tools, to detect the infection, to monitor COVID-19 pneumonia, and to potentially predict clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Impact of coronavirus disease 2019 (COVID-19) outbreak on radiology research: An Italian survey

et al. 2021

View full text Add to dashboard Cite

To understand how COVID-19 pandemic has changed radiology research in Italy. Methods: A questionnaire (n = 19 questions) was sent to all members of the Italian Society of Radiology two months after the first Italian national lockdown was lifted. Results: A total of 327 Italian radiologists took part in the survey (mean age: 49 ± 12 years). After national lockdown, the working-flow came back to normal in the vast majority of cases (285/327, 87.2%). Participants reported that a total of 462 radiological trials were recruiting patients at their institutions prior to COVID-19 outbreak, of which 332 (71.9%) were stopped during the emergency. On the other hand, 252 radiological trials have been started during the pandemic, of which 156 were non-COVID-19 trials (61.9%) and 96 were focused on COVID-19 patients (38.2%). The majority of radiologists surveyed (61.5%) do not conduct research. Of the radiologists who carried on research activities, participants reported a significant increase of the number of hours per week spent for research purposes during national lockdown (mean 4.5 ± 8.9 h during lockdown vs. 3.3 ± 6.8 h before lockdown; p = .046), followed by a significant drop after the lockdown was lifted (3.2 ± 6.5 h per week, p = .035). During national lockdown, 15.6% of participants started new review articles and completed old papers, 14.1% completed old works, and 8.9% started new review articles. Ninety-six surveyed radiologists (29.3%) declared to have submitted at least one article during COVID-19 emergency. Conclusion: This study shows the need to support radiology research in challenging scenarios like COVID-19 emergency.

show abstract

Clinical features of pulmonary cryptococcosis in thin-section CT in immunocompetent and non-AIDS immunocompromised patients

Cited by 26 publications

References 17 publications

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

Clinical analysis in immunocompetent and immunocompromised patients with pulmonary cryptococcosis in western China

Impact of coronavirus disease 2019 (COVID-19) outbreak on radiology research: An Italian survey

Contact Info

Product

Resources

About