Clinical Features of Spontaneous Regression of Retinopathy of Prematurity in China: A 5-Year Retrospective Case Series

Wang, Liang; Li, Manhong; Zhu, Jianping; Yan, Hongxiang; Wu, Lei; Fan, Jing; Zhou, Yi; Gou, Kaili; Zhang, Zifeng; Wang, Yusheng

doi:10.3389/fmed.2021.731421

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Furthermore, presence of retinal hemorrhage is also an inversely predictive factor for the spontaneous regression of ROP. Wang et al's [23] study also proved retinal hemorrhages was confirmed as dependent factors for delayed regression. In the case of retinal hemorrhages from a birth trauma, the mechanism of hemorrhage inducing, or aggravating ROP is still not clear.…”

Section: Resultsmentioning

confidence: 88%

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Li¹,

Cai²,

Yang³

2022

Int J Ophthalmol

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AIM: To investigate the ratio of spontaneous regression of retinopathy of prematurity (ROP) and to explore the possible relevant predictive factors. METHODS: A retrospective review of 405 infants who were diagnosed with ROP and mother during pregnancy were collected. Stage, zone, and duration of ROP were recorded. Statistical analysis was performed on 51 possible predictive factors. RESULTS: Totally 356 infants showed spontaneous regression. The incidence was 100%, 95.3%, and 22.7% in stage 1, 2, and 3, respectively. The 13.4% of the ROP with plus disease eventually resolved spontaneously. All affected eyes of aggressive posterior retinopathy of prematurity (AP-ROP) failed to spontaneously regress. The mean duration of ROP was 7.2wk in patients with spontaneous resolution of ROP. Days of mechanical ventilation (OR=0.981, 95%CI, 0.965-0.997, P=0.021), retinal hemorrhage (OR=0.173, 95%CI, 0.064-0.470, P=0.001), delivery pattern (OR=2.750, 95%CI, 1.132-6.681, P=0.025), maternal anemia in pregnancy (OR=0.142, 95%CI, 0.036-0.563, P=0.005), the stages (at initial diagnosis OR=0.183, 95%CI, 0.041-0.816, P=0.026; at final diagnosis OR=0.031, 95%CI, 0.006-0.167, P<0.001), and with plus disease or not (OR=0.005, 95%CI, 0.001-0.031, P<0.001) were independent predictive factors of the spontaneous regression of ROP. CONCLUSION: Most mild ROP can spontaneously resolve. Active treatment is still recommended for stage 3 ROP, zone I ROP, AP-ROP, and ROP with plus disease. Prolonged mechanical ventilation and concurrent retinal hemorrhage reduce the likelihood of spontaneous ROP resolution. The pattern of delivery and the mother’s anemia during pregnancy can also affect the prognosis of ROP.

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Section: Resultsmentioning

confidence: 88%

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Li¹,

Cai²,

Yang³

2022

Int J Ophthalmol

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“…This study aims to explore the predictive factors for severe ROP and to establish a nomogram for predicting severe ROP in southeast China. [14] . The International Classification of Retinopathy of Prematurity, Third Edition (ICROP3) [15] was used for diagnosis and staging of ROP.…”

Section: Introductionmentioning

confidence: 99%

Nomogram to predict severe retinopathy of prematurity in Southeast China

Liu,

He,

Jin

et al. 2024

Int J Ophthalmol

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AIM: To define the predictive factors of severe retinopathy of prematurity (ROP) and develop a nomogram for predicting severe ROP in southeast China. METHODS: Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were included. Clinical data and 43 candidate predictive factors of ROP infants were collected retrospectively. Logistic regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction, which was compared with WINROP model and Digirop-Birth model. RESULTS: Infants from the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University (n=478) were randomly allocated into training (n=402) and internal validation group (n=76). Infants from Taizhou Women and Children’s Hospital were set as external validation group (n=76). Severe ROP were found in 52 of 402 infants, 12 of 76 infants, and 7 of 76 infants in training group, internal validation group, and external validation group, respectively. Birth weight [odds ratio (OR), 0.997; 95% confidence interval (CI), 0.996-0.999; P<0.001], multiple births (OR, 1.885; 95%CI, 1.013-3.506; P=0.045), and non-invasive ventilation (OR, 0.288; 95%CI, 0.146-0.570; P<0.001) were identified as predictive factors for the prediction of severe ROP, by univariate analysis and multivariate analysis. For predicting severe ROP based on the internal validation group, the areas under receiver operating characteristic curve (AUC) was 78.1 (95%CI, 64.2-92.0) for the nomogram, 32.9 (95%CI, 15.3-50.5) for WINROP model, 70.2 (95%CI, 55.8-84.6) for Digirop-Birth model. In external validation group, AUC of the nomogram was also higher than that of WINROP model and Digirop-Birth model (80.2 versus 51.1 and 63.4). The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WINROP model and Digirop-Birth model. The calibration curves demonstrated a good consistency between the actual severe ROP incidence and the predicted probability. CONCLUSION: Birth weight, multiple births, and non-invasive ventilation are independent predictors of severe ROP. The nomogram has a good ability to predict severe ROP and performed well on internal validation and external validation in southeast China.

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Incomplete retinal vascularization with retinopathy of prematurity-like ridges in healthy full-term newborns

et al. 2023

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Clinical Features of Spontaneous Regression of Retinopathy of Prematurity in China: A 5-Year Retrospective Case Series

Cited by 6 publications

References 25 publications

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Nomogram to predict severe retinopathy of prematurity in Southeast China

Incomplete retinal vascularization with retinopathy of prematurity-like ridges in healthy full-term newborns

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