Clinical features of systemic lupus erythematosus in Sri Lankan patients: results from a lupus clinic

Galapatthy, P; Wazeel, AN; Nanayakkara, Sankha; Sheriff, Rezvi

doi:10.4038/cmj.v45i4.6589

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…74% were 20-40 years, with just over half belonging to the 21-30 year age group. These findings were comparable to studies done worldwide over the past ten years (1,4,5,9 ).…”

Section: Discussionsupporting

confidence: 91%

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The clinico-pathological features of lupus nephritis and the significance of ISN/RPS-2003 Class IV lesions

Perera

Mathivathani

2015

J Diagnostic Path

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“…74% were 20-40 years, with just over half belonging to the 21-30 year age group. These findings were comparable to studies done worldwide over the past ten years (1,4,5,9 ).…”

Section: Discussionsupporting

confidence: 91%

“…anti ds-DNA positivity was in concordance with similar studies reiterating the sensitivity of these markers in lupus nephritis (7,9). A neurological Paper Journal of Diagnostic Pathology 2014;9(2):14-22 disorder was found in a very small number of our patients, although it has been reported to be commoner in western studies (10,11).…”

Section: Discussionsupporting

confidence: 91%

The clinico-pathological features of lupus nephritis and the significance of ISN/RPS-2003 Class IV lesions

Perera

Mathivathani

2015

J Diagnostic Path

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“…5 Studies from Norway and Sri Lanka reported average age of 36 years and 32 years, respectively. 6,7 In our study, majority were females (85.42%) with male-to-female ratio 1:5.86. Thumboo et al, 8 Moss et al 9 and Estes and Christian 10 reported 93%, 92% and 91% female sex, respectively.…”

Section: Discussionsupporting

confidence: 48%

A Clinical Study of the Cutaneous Manifestations of Lupus Erythematosus

Issac¹,

Sobhanakumari²,

Surabhi³

et al. 2017

jebmh

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BACKGROUND Lupus Erythematosus (LE) is a group of heterogenous autoimmune diseases with an array of manifestations ranging from cutaneous lesions to life-threatening systemic manifestations. Cutaneous manifestations are the second most common feature and it serves as an important diagnostic aid. The nonspecific skin lesions are associated with more active disease. The aim of the study is to study the pattern and prevalence of cutaneous manifestations in LE and to study the correlation between cutaneous manifestations and systemic involvement. MATERIALS AND METHODS Study comprised of 48 patients of lupus erythematosus who attended the Department of Dermatology and Venereology in a tertiary referral centre from a period of November 2010 to November 2012. Patients were subjected to detailed clinical examination, routine investigations, ANA, anti-dsDNA, ANA profile, non-lesional skin biopsy for lupus band test. RESULTS 48 patients were taken for the study. The peak incidence was in the age group of 30-40 (33.33%) yrs. There was female predominance, the ratio being 5.86:1. Discoid Lupus Erythematosus (DLE) constitutes 37.5% and Systemic Lupus Erythematosus (SLE) 62.5%. Majority of DLE patients (38.89%) presented late in 5-9 yrs., whereas SLE patients presented early within 1-6 months (50%). Most frequent presenting features were arthralgia (54.17%), oral ulcers (45.83%). Renal system was the most common system affected (16.67%). Most common haematological abnormality was anaemia and raised ESR (40%). Most common immunological abnormality was raised ANA in 66.7% and raised anti-dsDNA (60%). Most frequent biochemical abnormality was albuminuria and raised 24-hours urine protein. Lupus band was positive in 58.33% and all had renal involvement. Mortality was 6.67%. CONCLUSION In this study, we got comparable results in epidemiological parameters like age and distribution with other studies. The incidence of ANA negative SLE was higher (33.33%) in our study. Though majority of patients with renal involvement had a positive lupus band test, a statistical significance could not be sought in this regard on account of low sample size.

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“…One observational study carried out in SL showed that 69% of patients developed renal involvements during a follow up of 3 years. The majority of them had focal or diffuse proliferative glomerulonephritis [ 6 ]. The current study aims to describe the clinicopathological findings, treatment response and predictors of long-term outcome of patients with WHO class III–IV LN in SL, managed according to the Euro-lupus regime.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological findings, treatment response and predictors of long-term outcome in a cohort of lupus nephritis patients managed according to the Euro-lupus regime: a retrospective analysis in Sri Lanka

et al. 2017

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BackgroundDespite the improvement in survival of patients with lupus nephritis (LN) globally, there is sparse data from Sri Lanka (SL). The current study aims to describe the clinicopathological findings, treatment response and predictors of long-term outcome of patients with WHO class III–IV LN in SL, managed according to the Euro-lupus regime.ResultsOf 72 patients, 64 were females. In half of them, LN was diagnosed within the 1st year of the illness. The most common presenting feature was sub-nephrotic proteinuria. Sixteen and twenty patients had nephrotic syndrome and abnormal renal function respectively at the time of diagnosis. Fifty-four patients (75%) responded to the Euro-lupus regimen [CR, 20 (28%); PR, 34(47%)]. Later at 6 months, 65 patients (90%) achieved remission [CR, 31(43%); PR, 34 (47%)]. Seven patients experienced treatment failure. During the total duration of follow up, 54 patients remained in complete or partial remission, 26 developed renal relapses, and 19 suffered severe infective episodes. Renal relapses were more common in people who achieved partial remission than complete remission. The long term renal outcome was not associated with age, sex, severity of proteinuria, class of LN or initial renal function. Patients who achieved remission at 6 months had a good long-term outcome.ConclusionsThe demographic and clinical features of WHO class III and IV LN in Sri Lankan patients were similar to that reported in the global literature. 75% of patients responded to the Euro-lupus regimen. Therefore, this regime is a suitable initial regimen for LN patients in SL. Good long-term renal outcome can be predicted by early response to therapy. Further studies are necessary to explore better treatment options for patients who fail to achieve remission during initial therapy.

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Clinical features of systemic lupus erythematosus in Sri Lankan patients: results from a lupus clinic

Abstract: Objectives To find the common clinical features, pattern of visceral involvement, treatment received and outcome in patients diagnosed as having systemic lupus erythe matosus (SLE) on American Rheumatological Association (ARA) criteria.

Cited by 7 publications

References 23 publications

The clinico-pathological features of lupus nephritis and the significance of ISN/RPS-2003 Class IV lesions

The clinico-pathological features of lupus nephritis and the significance of ISN/RPS-2003 Class IV lesions

A Clinical Study of the Cutaneous Manifestations of Lupus Erythematosus

Clinicopathological findings, treatment response and predictors of long-term outcome in a cohort of lupus nephritis patients managed according to the Euro-lupus regime: a retrospective analysis in Sri Lanka

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