Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection

Kylat, Ranjit I; Kelly, Edmond; Ford-Jones, E. Lee

doi:10.1007/s00431-006-0172-6

Cited by 127 publications

(97 citation statements)

References 26 publications

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“…The most common definition of symptomatic disease is the presence of $1 of the following symptoms at birth: petechiae, jaundice with conjugated hyperbilirubinemia, hepatosplenomegaly, thrombocytopenia, chorioretinitis, seizures, microcephaly, and intracranial calcifications. 3,4,28,34,49 Only studies that mentioned $3 of these symptoms were included. If there was no description or definition, studies were nevertheless included if there was a reference to an article with a similar definition.…”

Section: Methodsmentioning

confidence: 99%

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Hearing Loss and Congenital CMV Infection: A Systematic Review

Goderis¹,

Leenheer²,

et al. 2014

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BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance of cCMV infection in hearing-impaired children. METHODS:Two reviewers independently used Medline and manual searches of references from eligible studies and review articles to select cohort studies on children with cCMV infection with audiological follow-up and extracted data on population characteristics and hearing outcomes. RESULTS:Thirty-seven studies were included: 10 population-based natural history studies, 14 longitudinal cohort studies, and 13 retrospective studies. The prevalence of cCMV in developed countries is 0.58% (95% confidence interval, 0.41-0.79). Among these newborns 12.6% (95% confidence interval, 10.2-16.5) will experience hearing loss: 1 out of 3 symptomatic children and 1 out of 10 asymptomatic children. Among symptomatic children, the majority have bilateral loss; among asymptomatic children, unilateral loss predominates. In both groups the hearing loss is mainly severe to profound. Hearing loss can have a delayed onset, and it is unstable, with fluctuations and progression. Among hearing-impaired children, cCMV is the causative agent in 10% to 20%. Despite strict selection criteria, some heterogeneity was found between selected studies.CONCLUSIONS: This systematic review underscores the importance of cCMV as a cause of sensorineural hearing loss in childhood. Pediatrics 2014;134:972-982

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Section: Methodsmentioning

confidence: 99%

“…Outcomes for these infants are poor, and most survivors suffer from severe neurologic sequelae. 4,[33][34][35] The overall mortality rate is ,5%. 10,27,35,36 The majority of children with cCMV are asymptomatic and therefore not diagnosed at birth.…”

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confidence: 99%

Hearing Loss and Congenital CMV Infection: A Systematic Review

Goderis¹,

Leenheer²,

et al. 2014

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“…The most commonly observed symptoms of CMV infection at birth are intrauterine growth retardation, purpura, jaundice, hepatosplenomegaly, microencephaly, hearing impairment, and thrombocytopenia (11,142). While clinical signs due to abnormalities of the reticuloendothelial system (such as anemia, hepatosplenomegaly, and jaundice) are transient, neurological deficits either are evident at birth and typically persist for life or tend to become evident (as SNHL) in early childhood.…”

Section: Pathologymentioning

confidence: 99%

Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention

2009

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SUMMARY Congenital cytomegalovirus (CMV) infection is the leading infectious cause of mental retardation and hearing loss in the developed world. In recent years, there has been an improved understanding of the epidemiology, pathogenesis, and long-term disabilities associated with CMV infection. In this review, current concepts regarding the pathogenesis of neurological injury caused by CMV infections acquired by the developing fetus are summarized. The pathogenesis of CMV-induced disabilities is considered in the context of the epidemiology of CMV infection in pregnant women and newborn infants, and the clinical manifestations of brain injury are reviewed. The prospects for intervention, including antiviral therapies and vaccines, are summarized. Priorities for future research are suggested to improve the understanding of this common and disabling illness of infancy.

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“…Symptoms of congenital CMV infection in the neonatal period include hepatosplenomegaly, thrombocytopenia, petechiae, microcephaly, ventriculomegaly, and chorioretinitis. 66,67 Although the majority of infants with congenital CMV infection are initially asymptomatic at birth, both symptomatic and asymptomatic infants are at risk of long-term sequelae including mental impairment, sensorineural hearing loss, visual loss, and motor deficits. …”

Section: Premature Vlbw Infants Fetuses and Cmv-seronegative Pregnamentioning

confidence: 99%

Current strategies and future directions for the prevention of transfusion-transmitted cytomegalovirus

Harmon¹,

Cooling²

2017

IJCTM

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Cytomegalovirus (CMV) is a pervasive DNA virus that infects a significant portion of individuals worldwide, and may be transmitted through the transfusion of blood products. Although CMV infection is of little consequence in immunocompetent individuals, patients with an impaired immune system are at risk of significant morbidity and mortality. Unlike other blood-borne infectious agents, it is impractical to defer all CMV-positive individuals from blood donation as this would exclude a substantial number of otherwise eligible donors. Other methods such as transfusion of CMV-seronegative and leukoreduced blood products must be employed to prevent the transmission of CMV to at-risk patients. In this study, the widespread use of current strategies for the prevention of transfusion-transmitted CMV (TT-CMV) infection and the evidence to support these methods in various at-risk groups were reviewed. In addition, emerging pathogen inactivation technologies that have the potential to eliminate TT-CMV were also discussed.

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Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection

Abstract: There was only three (7%) patients without any deficits and severely affected infants have been identified with a diverse clinical presentation, reinforcing the importance of CMV as a major public health problem.

Cited by 127 publications

References 26 publications

Hearing Loss and Congenital CMV Infection: A Systematic Review

Hearing Loss and Congenital CMV Infection: A Systematic Review

Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention

Current strategies and future directions for the prevention of transfusion-transmitted cytomegalovirus

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