Clinical forms of Trypanosoma cruzi infected individuals in the chronic phase of Chagas disease in Puebla, Mexico

Sánchez-Guillén, María Del Carmen; López‐Colombo, Aurelio; Ordóñez-Toquero, Guillermo; Gomez-Albino, Isidoro; Ramos-Jimenez, Judith; Torres‐Rasgado, Enrique; Salgado-Rosas, Hilda; Romero-Díaz, M.; Pulido‐Perez, Patricia; Pérez-Fuentes, Ricardo

doi:10.1590/s0074-02762006000700005

Cited by 30 publications

(15 citation statements)

References 23 publications

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“…In Brazil and other countries in southern South America, TcI is less frequent in chronic chagasic patients, but most patients from Panama, Colombia, Ecuador, and Venezuela have been found to be infected with this DTU (Añez et al, 2004;Sousa et al, 2006;Herrera et al, 2007;Falla et al, 2009;Ocaña-Mayorga et al, 2010). Instances of patients infected with TcI who show severe cardiomyopathy have been reported from Colombia, Venezuela, and Paraíba state in northeastern Brazil, as well as from Mexico (Añez et al, 2004;Zafra et al, 2008;Ramírez et al, 2010), including severe clinical manifestations and even fatalities Sánchez-Guillén et al, 2006). In the present study, the classification of isolate PR-150 as TcI, by means of the rRNA and COII/RFLP, is compatible with the complete resistance of this isolate to benznidazole (Toledo et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Trypanosoma cruzi I–III in southern Brazil causing individual and mixed infections in humans, sylvatic reservoirs and triatomines

et al. 2011

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The aim of this study was to characterise Discrete Typing Units (DTUs) of 28 isolates of Trypanosoma cruzi from humans (15), triatomines (9), and opossums (4) in the state of Paraná, southern Brazil. For this purpose, we analysed the size polymorphism at the 3' end of the 24Sα ribosomal RNA gene (rRNA) and the restriction fragment length polymorphism (RFLP) of the partial 5' sequence of the mitochondrial Cytochrome Oxidase subunit II gene (COII). Band patterns of the isolates were compared with reference samples of T. cruzi I (Silvio X10 and Col 17G2), T. cruzi II (Esmeraldo and JG), T. cruzi III (222 and 231), T. cruzi IV (CAN III), T. cruzi V (SO3 cl5), and T. cruzi VI (CL Brener). Our results confirmed that rRNA analysis is of limited use for assessing T. cruzi DTUs. COII RFLP analysis was suitable for screening, but for one isolate it was necessary to determine the COII partial sequence to identify the DTU. Only one of the isolates from humans belonged to T. cruzi I; 13 isolates belonged to T. cruzi II and one to T. cruzi III. The four isolates from opossums and five isolates from triatomines were identified as T. cruzi I. Four isolates from triatomines showed patterns of both T. cruzi I and II, indicating mixed infections. This study contributes to the characterisation of the dynamics of T. cruzi populations in southern Brazil.

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Section: Discussionmentioning

confidence: 99%

Trypanosoma cruzi I–III in southern Brazil causing individual and mixed infections in humans, sylvatic reservoirs and triatomines

et al. 2011

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“…It is said that up to 30–40% of infected people will develop cardiac or digestive involvement during their life . These data are based on classical series from endemic areas and mostly published before 1990 . The most recent published series of chronic Chagas disease in non‐endemic countries show a different clinical profile, with younger patients and lower morbidity .…”

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi infection in a non-endemic country: epidemiological and clinical profile

Salvador

Treviño

Sulleiro

et al. 2014

Clinical Microbiology and Infection

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Chagas disease has been increasingly diagnosed in non-endemic countries. This is a prospective observational study performed at the Tropical Medicine Units of the International Health Program of the Catalan Health Institute, Barcelona (PROgrama de Salud Internacional del Instituto Catalán de la Salud, PROSICS Barcelona, Spain), that includes all patients with Chagas disease who attended from June 2007 to May 2012. Clinical and epidemiological data were collected. Overall, 1274 patients were included, the mean age of the patients was 37.7 years, 67.5% were women and 97% came from Bolivia. Thirteen patients had immunosuppressive conditions. The prevalence of cardiac involvement was 16.9%, lower than in previous studies performed in endemic areas (20-60%). Cardiac alterations were found in 33.8% of symptomatic and 14.1% of asymptomatic patients. The prevalence of digestive involvement was 14.8%. The rate of digestive involvement is very different among previous studies because of different diagnostic tools and strategies used. Barium enema alterations were found in 21.4% of symptomatic and 10.3% of asymptomatic patients, and oesophageal alterations were found in 3.7% of symptomatic and in 2.3% of asymptomatic patients. As shown in previous studies, Chagas disease in non-endemic countries affects younger patients and has lower morbidity.

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“…Its distribution extends from the southern USA to southern Latin America and it is estimated that 16-18 million people are infected and 100 million at risk of infection [1]. In immunocompetent patients, the parasite load decreases after the acute infection but persists at low levels during the chronic phase [5,6] and patients might develop visceral pathologies, possibly as a result of persistent infection and immune reactivation [7,8]. Patients with acute T. cruzi infection achieve high levels of parasitemia, regardless of their immune status.…”

Section: Trypanosoma and Hivmentioning

confidence: 99%

Mechanisms of interaction between protozoan parasites and HIV

Andreani

Lodge

Richard

et al. 2012

Current Opinion in HIV and AIDS

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Clinical forms of Trypanosoma cruzi infected individuals in the chronic phase of Chagas disease in Puebla, Mexico

Cited by 30 publications

References 23 publications

Trypanosoma cruzi I–III in southern Brazil causing individual and mixed infections in humans, sylvatic reservoirs and triatomines

Trypanosoma cruzi I–III in southern Brazil causing individual and mixed infections in humans, sylvatic reservoirs and triatomines

Trypanosoma cruzi infection in a non-endemic country: epidemiological and clinical profile

Mechanisms of interaction between protozoan parasites and HIV

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