Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)

Guo, Xiaodong; Feng, Yu; Sun, Tiansheng; Feng, Shiqing; Tang, Jiaguang; Chen, Lin; Cao, Xiaojian; Lin, Haodong; He, Xijing; Li, Mei-Hua; Zhi-cheng, Zhang; Yin, Guoyong; Mei, Xifan; Huang, Hongyun

doi:10.26599/jnr.2021.9040003

Cited by 44 publications

(25 citation statements)

References 176 publications

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“…These differences require doctors to provide more targeted and individualized treatments for patients with TLF. These epidemiological characteristics may provide recommendations for existing therapeutic guidelines for related diseases [23,24]. This study had several limitations.…”

Section: Discussionmentioning

confidence: 94%

Epidemiological characteristics of thoracolumbar fractures from 2014 to 2019 in Shanxi, China

Feng

Kang

et al. 2022

Preprint

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Background: We aimed to clarify the epidemiological characteristics of thoracolumbar fractures (TLFs) at Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, China. Methods: A total of 1,096 patients with TLF between January 2014 and December 2019 were included in this retrospective study. Epidemiological characteristics (year, age, sex, marital status, occupation, injury level, etiology, fracture type, and American Spinal Injury Association ASIA impairment scale [AIS] grade) in medical records were extracted and analyzed.Results: The number of TLF cases increased between 2014 and 2019. More than half of the patients were between 40 and 75 years old. The most common fracture level was L1, with compression as the most common injury type. A total of 137 patients (12.5%) experienced spinal cord injury. The primary cause of fracture was a “low fall”, and farmers were most vulnerable. Epidemiological characteristics (age, year, etiology, fracture type, occupation, and spinal cord injury) were quite different between males and females. In patients with spinal cord injury, the most frequent age group was 46–60 years old. Again, the primary fracture level was L1, and the most common occupation was farmer. However, with this group, the primary fracture type was burst, and the main etiology was “high fall”.Conclusions: The number of patients with TLF increases with social development. The epidemiological profiles between sexes were quite different. Preventions and government regulations should be implemented to reduce the incidence of TLF, according to the epidemiological profiles of men and women.

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Section: Discussionmentioning

confidence: 94%

Epidemiological characteristics of thoracolumbar fractures from 2014 to 2019 in Shanxi, China

Feng

Kang

et al. 2022

Preprint

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“…Definitive diagnosis with chest x-ray is very challenging [7] . Further due to initial neurological deficits this can be easily missed during the clinical assessment (Late diagnosis made in 9.5% of traumatic diaphragmatic injuries) [9] . Therefore clinical diagnosis requires a high level of suspicion [7] .…”

Section: Discussionmentioning

confidence: 99%

Rare association of traumatic diaphragmatic hernia with spinal cord injury: A case report

Rathnayaka

Pathinathan

Sivamynthan

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance The traumatic diaphragmatic hernia could be missed in the background of spinal fractures due to neurological weakness. We report the first case of the management of thoracolumbar fracture-dislocation associated with diaphragmatic injury. Presentation of case 53-year-old male transferred from local hospital following fallen from a motorbike on the 4th day after the injury. He was paraplegic from L1 below with sacral root involvement. Further imaging showed fracture-dislocation of the vertebral body at the T12-L1 level and anterior displacement of T11 on T12. The left-sided diaphragmatic hernia was detected by chest x-ray with bowel shadows in the left hemithorax. Emergency laparotomy and diaphragmatic repair followed by a posterior spinal exploration and pedicle screw fixation were done. Early mobilization was done after spinal fixation and the patient is successfully continuing rehabilitation. Clinical discussion Thoracolumbar fracture-dislocation associated with the traumatic diaphragmatic hernia is rare. Clinical diagnosis of associated visceral injuries could be delayed due to the neurological deficit of the patient. An initial concern was to repair the life-threatening diaphragmatic hernia. Even current studies showed improved neurological function from early spinal surgery, spinal fixation had to delay as surgery needs a prone position. Conclusion Early identification and management of traumatic diaphragmatic hernia are life-saving and allows early surgical intervention for the spine. Early reduction and fixation are associated with improved neurological function and will allow early mobilization and reduce hospital and ICU stay.

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“…Chemotherapy as one of the most commonly used cancer treatments is severely affected by drug dosage and drug toxicity ( Deng et al, 2015 ; Sun et al, 2021 ). The prognosis of gliomas is often poor, and chemotherapy resistance remains the challenge in therapy of human glioma ( da Silva., et al, 2020 ; Ding et al, 2020 ; Guo et al, 2021 ). A safe dose of chemotherapeutic drugs may not cure cancer patients, while high-dose drugs have a more significant therapeutic effect but higher drug toxicity and side effects ( Song et al, 2016 ; Sun et al, 2020 ).…”

Section: Introductionmentioning

confidence: 98%

RGD Peptide-Conjugated Selenium Nanocomposite Inhibits Human Glioma Growth by Triggering Mitochondrial Dysfunction and ROS-Dependent MAPKs Activation

Liu

Shi

et al. 2021

Front. Bioeng. Biotechnol.

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Chemotherapy is still one of the most common ways to treat human glioblastoma in clinic. However, severe side effects limited its clinic application. Design of cancer-targeted drugs with high efficiency and low side effect is urgently needed. Herein, silver nanoparticles (Ag NPs) and nano-selenium (Se NPs) conjugated with RGD peptides (Ag@Se@RGD NPs) to target integrin high-expressed glioma were designed. The results found that Ag@Se@RGD NPs displayed stable particle size and morphology in physiological condition, and induced significant integrin-targeted intracellular uptake. Ag@Se@RGD NPs in vitro dose-dependently inhibited U251 human glioma cells growth by induction of cells apoptosis through triggering the loss of mitochondrial membrane potential, overproduction of reactive oxygen species (ROS), and MAPKs activation. However, ROS inhibition dramatically attenuated Ag@Se@RGD NPs-induced MAPKs activation, indicating the significant role of ROS as an early apoptotic event. Importantly, Ag@Se@RGD NPs administration in vivov effectively inhibited U251 tumor xenografts growth by induction of apoptosis through regulation MAPKs activation. Taken together, our findings validated the rational design that Ag-Se NPs conjugated with RGD peptides was a promising strategy to combat human glioma by induction of apoptosis through triggering mitochondrial dysfunction and ROS-dependent MAPKs activation.

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Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)

Cited by 44 publications

References 176 publications

Epidemiological characteristics of thoracolumbar fractures from 2014 to 2019 in Shanxi, China

Epidemiological characteristics of thoracolumbar fractures from 2014 to 2019 in Shanxi, China

Rare association of traumatic diaphragmatic hernia with spinal cord injury: A case report

RGD Peptide-Conjugated Selenium Nanocomposite Inhibits Human Glioma Growth by Triggering Mitochondrial Dysfunction and ROS-Dependent MAPKs Activation

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