Clinical, haematological and molecular studies in patients with chromosome translocation t(7;11): a study of four Chinese patients in Taiwan

Abstract

Translocation t(7;11)(p15;p15) is an uncommon but recurrent chromosome aberration in acute myeloid leukaemia (AML), which occurs mostly in oriental patients and in AML M2 or, occasionally, M4 subtype. Recently, a consistent chimaeric fusion transcript NUP98‐HOXA9 was found in several cases of t(7;11). Four AML cases with the chromosome abnormality in Taiwan are described. They were all adults with ages ranging from 30 to 41 years (median 36 years). Three of them were diagnosed as having AML M2; the remaining one as M4. Marked dyserythropoiesis was demonstrated in two patients. All four patients showed pan‐myeloid antigen CD13 on the leukaemic cells, but none coexpressed lymphocyte‐associated antigens and neither of the two patients studied for CD34 expression had positive staining. NUP98‐HOXA9 fusion transcript was detected in both patients who had molecular analysis and the breakpoints on chromosome 11 and 7 respectively were similar to those previously reported. They all received conventional induction chemotherapy, but only one achieved a complete remission (CR) with short duration. This study and others reported in the literature suggest a racial or geographical predisposition among oriental patients to AML with t(7;11) and that this is associated with a poor prognosis. The molecular detection of NUP98‐HOXA9 fusion transcript would be a useful method for the diagnosis of t(7;11) and also for monitoring disease status after treatment.

NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique

“…[40][41][42][43] The incidence of chromosome-associated NUP98 rearrangements observed in patients with various hematopoietic malignancies 16,38,43,44 is low (1-2%). In comparison, other genes such as MLL, RUNX1 and TEL/ETV6 rearrange frequently in hematological malignant disorders.…”

Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23

“…24 Total cellular RNAs were extracted from cryopreserved cells by a modified one-step guanidinium thiocyanate-phenol-chloroform method using RNAzol B commercial reagent (Biotecx Laboratories, Houston, TX, USA) as described previously. 25 …”

Outcomes after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia harboring t(7;11)(p15;p15)

“…While its actual prognostic relevance remains unclear, extremely high incidences of relapse in patients with t(7;11)(p15;p15) have been reported. [2][3][4][5] Although the cumulative incidence of relapse in the t(7;11)(p15;p15) group was significantly higher than that in the intermediate-risk group, there were no significant differences in survival between the two groups. Although these results suggest that allogeneic HSCT might overcome or at least ameliorate the poor prognosis of AML with t(7;11)(p15;p15), the present study is retrospective, and further prospective studies comparing allogeneic HSCT and chemotherapies are warranted to determine the prognostic relevance of AML harboring t(7;11)(p15;p15).…”

“…Kaito Harada, 1,2 Noriko Doki, 1 Jun Aoki, 3 Jinichi Mori, 4 Shinichiro Machida, 2 Masayoshi Masuko, 5 Naoyuki Uchida, 6 Yuho Najima, 1 Takahiro Fukuda, 7 Heiwa Kanamori, 3 Hiroyasu Ogawa, 8 Shuichi Ota, 9 Kazuei Ogawa, 10 Satoshi Takahashi, 11 Masanobu Kasai, 12 Akio Maeda, 13 Koji Nagafuji, 14 Toshiro Kawakita, 15 Tatsuo Ichinohe 16 and Yoshiko Atsuta…”