2023
DOI: 10.3389/fneur.2023.1189278
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Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer’s disease

Dominique Gouilly,
Anne-Sophie Salabert,
Elsa Bertrand
et al.

Abstract: The relationship between neuroinflammation and cognition remains uncertain in early Alzheimer’s disease (AD). We performed a cross-sectional study to assess how neuroinflammation is related to cognition using TSPO PET imaging and a multi-domain neuropsychological assessment. A standard uptake value ratio (SUVR) analysis was performed to measure [18F]-DPA-714 binding using the cerebellar cortex or the whole brain as a (pseudo)reference region. Among 29 patients with early AD, the pattern of neuroinflammation wa… Show more

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Cited by 3 publications
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“…Furthermore, TSPO expression is not the only indicator of inflammatory activity, and it may be associated with the activation of other cell types, such as astrocytes. [ 25 , 33 ] Therefore, future studies need to include more biomarkers to be able to more fully reflect the neuroinflammatory state of dementia.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, TSPO expression is not the only indicator of inflammatory activity, and it may be associated with the activation of other cell types, such as astrocytes. [ 25 , 33 ] Therefore, future studies need to include more biomarkers to be able to more fully reflect the neuroinflammatory state of dementia.…”
Section: Discussionmentioning
confidence: 99%