Clinical, histological and high-frequency ultrasonographic evaluation (50 MHz) of morphoea treated with ultraviolet A1 phototherapy

Arisi, Mariachiara; Lorenzi, Luisa; Incardona, Paolo; Fusano, Marta; Zanca, A; Tomasi, Cesare; Calzavara‐Pinton, Piergiacomo; Venturini, Marina

doi:10.1111/ced.13693

Cited by 17 publications

(22 citation statements)

References 19 publications

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“…In a study of 16 patients with morphea and four with extragenital lichen sclerosis, the results of HFUS demonstrated unique features of extragenital lichen sclerosis characterized by widened, polycyclic, hyperechoic and disorganized epidermal entry echo relative to that seen in morphea [62]. Another study using UHFUS to measure response to treatment demonstrated a statistically significant decrease in dermal thickness and density after treatment with ultraviolet A1 phototherapy [66].…”

Section: Sclerosing Disordersmentioning

confidence: 99%

High-frequency ultrasound in clinical dermatology: a review

et al. 2021

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Background Ultrasound was first introduced in clinical dermatology in 1979. Since that time, ultrasound technology has continued to develop along with its popularity and utility. Main text summary Today, high-frequency ultrasound (HFUS), or ultrasound using a frequency of at least 10 megahertz (MHz), allows for high-resolution imaging of the skin from the stratum corneum to the deep fascia. This non-invasive and easy-to-interpret tool allows physicians to assess skin findings in real-time, enabling enhanced diagnostic, management, and surgical capabilities. In this review, we discuss how HFUS fits into the landscape of skin imaging. We provide a brief history of its introduction to dermatology, explain key principles of ultrasonography, and review its use in characterizing normal skin, common neoplasms of the skin, dermatologic diseases and cosmetic dermatology. Conclusion As frequency advancements in ultrasonography continue, the broad applications of this imaging modality will continue to grow. HFUS is a fast, safe and readily available tool that can aid in diagnosing, monitoring and treating dermatologic conditions by providing more objective assessment measures.

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Section: Sclerosing Disordersmentioning

confidence: 99%

High-frequency ultrasound in clinical dermatology: a review

et al. 2021

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“…The same trained operator(s) should be included in this study. For each variable of interest, measurement and evaluation of the parameters should be performed with only one replica, duplicate or triplicate, using one to three trained independent operators 4,13,31,32,34,36,37 . Averages were used in subsequent analyses.…”

Section: Reproducibility Parameters By Hfus Skin Analysismentioning

confidence: 99%

“…Studies in dermatology have increasingly used 50 MHz ultrasound to reach sufficient depths and visualize dermal and epidermal phenomena with more appreciable alterations, because of its remarkable high‐resolution imaging of the cross‐section of the skin 12–14 . However, a limitation is that penetration capacity is significantly limited in high‐frequency devices with a fixed working frequency (3–4 mm at 50 MHz) 12 .…”

Section: Introductionmentioning

confidence: 99%

High‐frequency ultrasound as a scientific tool for skin imaging analysis

Vergilio

Silva

Jales

et al. 2021

Experimental Dermatology

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Ultrasonic imaging is one of the most important diagnostic tools in clinical medicine due to its cost, availability and good correlation with pathological results. High‐frequency ultrasound (HFUS) is a technique used in skin science that has been little explored, especially in comparison with other sites and imaging techniques. HFUS shows real‐time images of the skin layers, appendages and skin lesions in vivo and can significantly contribute to advances in skin science. This review summarizes the potential applications of HFUS in dermatology and cosmetology, with a focus on quantitative tools that can be used to assess various skin conditions. Our findings showed that HFUS imaging is a reproducible and powerful tool for the diagnosis, clinical management and therapy monitoring of skin conditions. It is also a helpful tool for assessing the performance of dermatological products. This technique may eventually become essential for evaluating the performance of dermatological and cosmetic products.

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“…Skin ultrasound allows a follow-up of LS lesions and has been proposed as a non-invasive, real-time imaging technique to assess and monitor the severity of localized scleroderma (LS) 35,37,[45][46][47][48][49][50][51][52][53] (Table 2). As far back as 30 years ago, it was recommended that B-mode skin ultrasound be used in clinical practice to evaluate LS patients.…”

Section: Recent Acquisitions In the Use Of Ultrasound In The Study Of Localized Sclerodermamentioning

confidence: 99%

“…HUS revealed a post-UVA1 treatment improvement in dermal hypoechogenic bands and a significant decrease in yoyo images. 45 As aforementioned, echogenicity changes may also help to distinguish active LS skin lesions from inactive ones. Li et al evaluated 21 pediatric LS patients with HUS (8-14 MHz) (32 scans of active lesions and 20 scans of inactive ones) and observed that active lesions seemed to be more echogenic than inactive ones, with a statistically significant difference in the hypodermis and deep tissue layers.…”

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confidence: 95%

The Updated Role of Ultrasound in Assessing Dermatological Manifestations in Systemic Sclerosis

Ruaro¹,

Santiago²,

Hughes³

et al. 2021

OARRR

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Systemic sclerosis (SSc), an autoimmune connective tissue disease, characterized by skin fibrosis, increased dermal thickness and microvascular involvement. Fibroblasts and myofibroblasts deposit excessive amounts of collagenous and non-collagenous extracellular matrix components in the skin. This leads to microvascular abnormalities and Raynaud’s phenomenon, with painful digital ulcers (DU) at the fingertips adding to patient discomfort. The skin involvement and severity in SSc was evaluated by the Modified Rodnan skin score (mRSS). Although high-frequency ultrasound (HUS) has been widely researched in the study of skin thickness and DU in SSc, its adoption into clinical practice is not yet common. However, novel insights into the still relatively unknown disease pathogenesis in SSc and its evaluation may be provided by HUS, including early (pre-clinical) skin involvement. It may also be useful in both the evaluation and follow-up of DU. Indeed, it is a non-invasive, safe, inexpensive and reproducible method able to assess not only SSc patients’ cutaneous structural changes, but also their vascular system changes. Moreover, several recent studies have reported that elastosonography (ES) is of use when investigating skin involvement in systemic sclerosis. This review aims at providing information as to role HUS and ES play in research advancements and the clinical perspectives in the evaluation of skin thickness and DU in SSc patients.

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Clinical, histological and high-frequency ultrasonographic evaluation (50 MHz) of morphoea treated with ultraviolet A1 phototherapy

Abstract: Ultrasonographic pattern analysis of morphoea is a suitable technique for monitoring UVA1 phototherapy response.

Cited by 17 publications

References 19 publications

High-frequency ultrasound in clinical dermatology: a review

High-frequency ultrasound in clinical dermatology: a review

High‐frequency ultrasound as a scientific tool for skin imaging analysis

The Updated Role of Ultrasound in Assessing Dermatological Manifestations in Systemic Sclerosis

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