Clinical, histological and immunohistochemical findings in oral Kaposi's sarcoma in a series of Mexican AIDS patients. Comparative study

Ramírez‐Amador, Velia; Martínez-Mata, Guillermo; González-Ramírez, Imelda; Anaya‐Saavedra, Gabriela; Almeida, Oslei Paes de

doi:10.1111/j.1600-0714.2008.00740.x

Cited by 27 publications

(27 citation statements)

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“…Reliable data on D2-40 expression in classic KS cases are limited. D2-40 staining ratios ranged between 90 and 100% in neoplastic cells of KS [17,[19][20][21][22][23][24]26]. Fukunaga et al reported that D2-40 immunoreactivity was positively correlated with histological stage in KS [30].…”

Section: Discussionmentioning

confidence: 99%

“…When the disease was first defined, the tumors were thought to originate from blood vessel endothelium [10][11][12][13][14][15][16][17]. Recent trials, however, have shown that lymphatic origin or differentiation may play a key role in the histogenesis of KS [18][19][20][21][22][23][24]. Some researchers have claimed that the neoplastic cells of KS originate from endothelial progenitor cells, and that blood and lymphatic vessel endothelium may each differentiate into both cell types [25].…”

Section: Introductionmentioning

confidence: 99%

“…Only a limited number of trials have assessed the lymphatic origin and differentiation of KS. Furthermore, most trials have focused on AIDS-related KS [13][14][15][16][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Lymphatic Differentiation in Classic Kaposi’s Sarcoma: Patterns of D2-40 Immunoexpression in the Course of Tumor Progression

Kandemır

Barut

Gün

et al. 2011

Pathol. Oncol. Res.

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The recent development of lymphatic endothelium-specific immuno-indicators has given rise to research on the histogenesis of Kaposi sarcoma (KS), specifically focusing on its lymphatic root and differentiation. D2-40 is a new lymphatic marker that recognizes podoplanin and is easily applied to formalin-fixed paraffin-embedded human tissues. This study examined D2-40 immunoexpression in 178 classical KS lesions using immunohistochemical methods. D2-40 immunoexpression was also examined in 63 non-KS soft tissue lesions to test the reliability of D2-40 monoclonal antibody in the pathological diagnosis of KS. D2-40 immunoreactivity was detected at all of the KS lesions and in lymphangioma and nonneoplastic lymphatic endothelium. There was no significant relationship between the extent of D2-40 staining and histopathological stage; however, there was a positive correlation between the staining intensity and histopathological stage in KS cases. D2-40 immunoreactivity was detected at all histopathological stages of KS and may be added to the routine immunohistochemical panel used for the differential diagnosis of KS. Widespread D2-40 protein expression is evidence of a lymphatic origin or the differentiation of neoplastic cells in KS, and D2-40 expression increases with tumor progression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lymphatic Differentiation in Classic Kaposi’s Sarcoma: Patterns of D2-40 Immunoexpression in the Course of Tumor Progression

Kandemır

Barut

Gün

et al. 2011

Pathol. Oncol. Res.

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“…Kaposi's sarcoma (KS) is an angioproliferative disorder characterized by proliferation of spindle-shaped cells, neoangiogenesis, inflammation and oedema, and categorized as an intermediate neoplasm due to the absence of conventional features of malignancy [1] . It was first described in 1872 by Moritz Kaposi [2] .…”

Section: Introductionmentioning

confidence: 99%

Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient

Zoubeidi

Aydi

Daoud

et al. 2016

European Journal of Case Reports in Internal Medicine

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Introduction Kaposi’s sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. We describe the case of an elderly HIV-negative patient presenting with lymphadenopathy who was found to have KS. Case Report A 67-year-old patient was admitted for exploration of polyadenopathies in the context of a general decline in health. Physical examination revealed an erythematosus left lower limb rash associated with angiomatous nodules and multiple lymphadenopathies. The diagnosis of erysipelas in the left leg was retained and the patient was treated with good evolution of the rash but persistence of the angiomatous nodules and the polyadenopathies. Skin and lymph node biopsies led to a diagnosis of KS. The patient is proposed for polychemotherapy. Conclusion KS must be suspected in lymphadenopathies despite the absence of typical cutaneous signs of the disease and in immunocompetent patients. LEARNING POINTS Involvement of the lymph nodes is extremely uncommon in the classical variant form of Kaposi’s sarcoma (KS). Human herpes virus-8 is an important cofactor in all forms of KS. Pathology and immunohistochemistry are key to diagnosing KS. KS must be suspected in lymphadenopathies without typical cutaneous signs of the disease and in immunocompetent patients.

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“…Kaposi's sarcoma is an angioproliferative disorder characterized by proliferation of spindle-shaped cells, neo-angiogenesis, inflammation and edema [29][30]. Four major forms have been identified: Classic, African endemic, Immunosuppression-associated or transplant-associated, and AIDS-associated [31][32].…”

Section: Kaposi's Sarcoma (1 Case)mentioning

confidence: 99%

Diagnosis and Treatment of Head and Neck Sarcomas: Personal Experiences

Laus¹

2013

JCTR

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Sarcomas are a rare group of tumors. They do not commonly manifest as malignancies in the head and neck region. The rare nature of these tumors has resulted in a limited number of publications. This is a descriptive study. We included patients with primary sarcomas of the head and neck, observed between 1991 and 2011 in the department of Otorhinolaryngology (University of Chieti, Italy). We studied the following variables: age, gender, race, origin, primary anatomical location of the neoplasm, pathology, diagnosis and type of cancer treatment employed. During the study period, we found 9 patients with head and neck sarcomas. Of this sample, 6 were males, and 3 were females. The man/woman ratio was 2:1. As far as age is concerned, the most affected age range was between 60 and 80 years. The mean age of the patients was 62. As far as pathology is concerned, we found 7 histopathological variations of sarcomas, and the most common type was the leiomyosarcoma. The most widely used treatment modality was surgical treatment. The data in this study show that head and neck sarcomas are rare tumors with high histological variability, which may involve different anatomical sites. Since these are rare and not well-known lesions, further epidemiological studies must be carried out, in order to give us more knowledge about the disease.

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Clinical, histological and immunohistochemical findings in oral Kaposi's sarcoma in a series of Mexican AIDS patients. Comparative study

Abstract: The expression of D2-40 marker in the vascular walls and SC supports the view of a lymphatic differentiation in neoplastic cells of OKS. Desmin, alpha SMA, D2-40, C-kit and HHV-8 were the main markers differently expressed in OKS and OPG.

Cited by 27 publications

References 32 publications

Lymphatic Differentiation in Classic Kaposi’s Sarcoma: Patterns of D2-40 Immunoexpression in the Course of Tumor Progression

Lymphatic Differentiation in Classic Kaposi’s Sarcoma: Patterns of D2-40 Immunoexpression in the Course of Tumor Progression

Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient

Diagnosis and Treatment of Head and Neck Sarcomas: Personal Experiences

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