Clinical Hypersensitivity to Cigarette Smoke

Savel, Herbert

doi:10.1080/00039896.1970.10667212

Cited by 33 publications

(4 citation statements)

References 11 publications

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“…Some authors ( 5 , 66,82) have proposed that a person can develop a true allergy to tobacco smoke. However, this theory has never been proved, and the studies in question seem to be controversial.…”

Section: Passive Smokingpossible Mechanisms and Consequencesmentioning

confidence: 99%

Passive smoking as a risk factor for development of obstructive respiratory disease and allergic sensitization

Halken

Høst

Nilsson

et al. 1995

Allergy

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Halken S, Host A, Nilsson L, Taudorf E. Passive smoking as a risk factor for development of obstructive respiratory disease and allergic sensitization. Halken et al. 1991 (31) Wright et al. 1991 (79) Halken et al. 1992 132) n=10. 106.6-16 yr 68 43 59 n=3482,0-19 yr 62 3. 27+ 32 16 nr186.0-18 mo 43 22 37 16 n=9670,0-10 yr 50 56 n=278,0-18 mo 58 42 41 39 34 ~8 4 7 , 10-12 mo 39 26 30 16 61 n=108 HR infants, 0-18 mo 45 25 38 44 M=Mother; F=Father; M/F only; HR=high-risk infantsdefined as having severe single atopic predisposition combined with cord-blood IgE2 0.05 kU/l or biparental atopic predisposition. 30, 37, 77).Cotinine and nicotine can also be measured in breast milk, and concentrations of nicotine increased 10-fold when the mother smoked just before nursing (15). In a recent study (68), cotinine

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Section: Passive Smokingpossible Mechanisms and Consequencesmentioning

confidence: 99%

Passive smoking as a risk factor for development of obstructive respiratory disease and allergic sensitization

Halken

Høst

Nilsson

et al. 1995

Allergy

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“…In connection with the question of induction of allergic reactions by smoke constituents, Schoen & Pizer (1964), Schroder (I967) and Savel (1970) reported on various findings. They observed changes of leucocytes during allergic reactions and, using various methods of examination, they tried to study the significance of tobacco constituents on changes of the blood.…”

Section: Leucocytesmentioning

confidence: 99%

Biochemical and haematological investigations in syrian golden hamsters after cigarette smoke inhalation

et al. 1974

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“…Cigarette smoke inhalation has been implicated in the etiology and pathogenesis of a number of respiratory diseases in man (12), and recently attention has been drawn to the possible role of immune suppression in the development of some of these diseases (9). Scattered information in the literature (4,5,7,8,11,16) indicates that the immune system in man may be affected to some degree by smoking, and chronic inhalation experiments in this laboratory using small animals have clearly shown progressive depression of both humoral and cell-mediated immunity during exposure (13)(14)(15).…”

mentioning

confidence: 99%

Cigarette Smoking, Air Pollution, and Immunity: a Model System

1974

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BALB/c mice were exposed to fresh cigarette smoke, a mixture of SO 2 (5 ppm) and CO (50 ppm), or both for periods up to 18 weeks. After varying exposure times, animals were intratracheally inoculated with 10 8 sheep erythrocytes and sacrificed 7 days later, during which time the various exposure regimes were continued. Plaque-forming-cell responses were measured in spleens and a pool of the cervical and mediastinal lymph nodes, together with serum hemagglutinating and hemolytic responses, and compared with those of age-matched control animals. Both the organ and serum responses exhibited stimulation in the early phase of exposure, before a depression with prolonged exposure. The greatest depression was seen in animals that had been chronically exposed to both fresh cigarette smoke and the gas mixture.

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Clinical Hypersensitivity to Cigarette Smoke

Cited by 33 publications

References 11 publications

Passive smoking as a risk factor for development of obstructive respiratory disease and allergic sensitization

Passive smoking as a risk factor for development of obstructive respiratory disease and allergic sensitization

Biochemical and haematological investigations in syrian golden hamsters after cigarette smoke inhalation

Cigarette Smoking, Air Pollution, and Immunity: a Model System

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