1977
DOI: 10.1056/nejm197707142970204
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Clinical Immunity in Acute Gastroenteritis Caused by Norwalk Agent

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Cited by 419 publications
(321 citation statements)
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“…An explanation for this can be the distinct pattern of immunity between both types of viruses. As above pointed out, protective immunity against rotavirus infection is universal after the first couple of life years in contrast to norovirus which does not induce lasting immunity [45] among others because of the great genetic variability of the genome of the virus.…”
Section: Virusesmentioning
confidence: 99%
“…An explanation for this can be the distinct pattern of immunity between both types of viruses. As above pointed out, protective immunity against rotavirus infection is universal after the first couple of life years in contrast to norovirus which does not induce lasting immunity [45] among others because of the great genetic variability of the genome of the virus.…”
Section: Virusesmentioning
confidence: 99%
“…Susceptibility to norovirus infection involves both acquired immunity and genetic resistance (Parrino et al, 1977). Volunteer studies found that some individuals were repeatedly susceptible to norovirus infection whereas others were repeatedly resistant (Parrino et al, 1977).…”
Section: Host Susceptibility and Virus-host Interactionmentioning
confidence: 99%
“…Volunteer studies found that some individuals were repeatedly susceptible to norovirus infection whereas others were repeatedly resistant (Parrino et al, 1977). Although it was initially unclear why some subjects did not develop illness, current research suggests that host genotype is a prominent factor in the development of norovirus infection since it depends on the presence of specific human histo-blood group antigen (HBGA) receptors in the gut of susceptible hosts (Lindesmith et al, 2003).…”
Section: Host Susceptibility and Virus-host Interactionmentioning
confidence: 99%
“…Furthermore, volunteer studies have shown that protective immunity after infection may be absent or short-lived (Parrino et al, 1977). The combination of antigenic diversity and the apparent lack of long term protective immunity are the likely cause of the occurrence of norovirus infections in children, adults and the elderly.…”
Section: Norovirusmentioning
confidence: 99%