Primary immunodeficiency disease (PID) comprises a genetically heterogeneous group of disorders caused by defects in components of the immune system. PIDs affect different components of the innate and adaptive immune systems, including neutrophils, macrophages, dendritic cells, complement proteins, natural killer (NK) cells, and T-and B-lymphocytes. [1 2] This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.