2010
DOI: 10.1111/j.1365-2249.2010.04296.x
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Clinical immunology review series: an approach to desensitization

Abstract: ARTICLES PUBLISHED IN THIS CLINICAL IMMUNOLOGY REVIEW SERIES SummaryAllergen immunotherapy describes the treatment of allergic disease through administration of gradually increasing doses of allergen. This form of immune tolerance induction is now safer, more reliably efficacious and better understood than when it was first formally described in 1911. In this paper the authors aim to summarize the current state of the art in immunotherapy in the treatment of inhalant, venom and drug allergies, with specific re… Show more

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Cited by 47 publications
(28 citation statements)
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References 141 publications
(175 reference statements)
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“…The cytokine profile of Th2 cells is pro allergenic, primarily because IL-4 promotes the class switching of immunoglobulins in B cells, giving rise to the synthesis of allergen-specific IgE [8] the study report the decreasing of IL-4 level after supplementation probiotic but no statistical significant. Similar to previous studies [11], [12] probiotic therapy was accompanied by only moderate changes in production of the cytokines IL-4, IFN-γIL-10, and IL-2. IL-4 stimulates B lymphocytes to produce IgE.…”
Section: Discussionsupporting
confidence: 71%
“…The cytokine profile of Th2 cells is pro allergenic, primarily because IL-4 promotes the class switching of immunoglobulins in B cells, giving rise to the synthesis of allergen-specific IgE [8] the study report the decreasing of IL-4 level after supplementation probiotic but no statistical significant. Similar to previous studies [11], [12] probiotic therapy was accompanied by only moderate changes in production of the cytokines IL-4, IFN-γIL-10, and IL-2. IL-4 stimulates B lymphocytes to produce IgE.…”
Section: Discussionsupporting
confidence: 71%
“…In brief, ITI for these conditions consists of carefully monitored, graded, increasing re-exposure to the antigen of interest with or without additional immunosuppression [10][11][12][13]. But ITI, as used in these conditions, has not been described in patients sensitized to RBC, platelet, or neutrophil antigens, or IgA.…”
Section: Introductionmentioning
confidence: 98%
“…Scientific efforts to ameliorate the effectiveness of allergen specific immunotherapy (SIT) are focused on use of hypoallergenic antigens, 1,2 new adjuvants, 3 or vehicles for an optimal antigen presentation to the immune system. 4 Notably, few studies reported the development of SIT strategies based on the construction of live recombinant bacteria expressing the allergen, to be used as mucosal vaccines.…”
Section: Introductionmentioning
confidence: 99%