2023
DOI: 10.3892/ol.2023.13970
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Clinical impact of age‑specific distribution of combination patterns of cytology and high‑risk HPV status on cervical intraepithelial neoplasia grade 2 or more

Abstract: To the best of our knowledge, the present study is the first to elucidate the significance of cytology and high-risk human papillomavirus (hrHPV) status in different age groups for the detection of cervical intraepithelial neoplasia (CIN)2, CIN3 and squamous cell carcinoma (SCC). There were 12 combinations based on cytology and hrHPV status [cytology: Atypical squamous cells (ASC) of undetermined significance, low-grade squamous intraepithelial lesion, ASC not excluding high-grade squamous intraepithelial lesi… Show more

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Cited by 2 publications
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“…Extant studies show that the characteristics of distribution of high-risk HPV types differ with increasing age in patients with CIN2+. For instance, HPV-16 and -18 types cause CIN more often in younger women than in older women who are affected by genotypes other than those associated with non-high-risk HPV ( 27 , 28 ). The reason for the atypical age-related distribution of HPV genotypes in older women is immunological status ( 29 ).…”
Section: Discussionmentioning
confidence: 99%
“…Extant studies show that the characteristics of distribution of high-risk HPV types differ with increasing age in patients with CIN2+. For instance, HPV-16 and -18 types cause CIN more often in younger women than in older women who are affected by genotypes other than those associated with non-high-risk HPV ( 27 , 28 ). The reason for the atypical age-related distribution of HPV genotypes in older women is immunological status ( 29 ).…”
Section: Discussionmentioning
confidence: 99%