Clinical impact of human breast milk metabolomics

Marincola, Flaminia Cesare; Dessì, Angelica; Corbu, Sara; Reali, Alessandra; Fanos, Vassilios

doi:10.1016/j.cca.2015.02.021

Cited by 55 publications

(48 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Within this context, it must be remembered that benefits of human milk include improvement of feeding tolerance, risk-reduction of re-hospitalization due to infectious diseases, and neurodevelopment optimization. Thus, there is wide consensus in recognizing human milk feeding as a cost-effective strategy in order to reduce economic costs related to prematurity and to aim to a personalized therapy improving the quality of care in these infants [8]. These characteristics call for considering human milk promotion and support in these vulnerable infants as a public health issue.…”

mentioning

confidence: 99%

Human Milk Feeding in Preterm Infants: What Has Been Done and What Is to Be Done

2019

View full text Add to dashboard Cite

Keywords: breastfeeding; human milk; human donor milk; promotion of breastfeeding; preterm infant; VLBW Human milk is recommended as the natural feeding for both term and preterm infants for the several health benefits associated with its consumption. The importance of human milk is not only limited to its nutritional value but it also includes the provision of bioactive factors involved in the optimization of infants' growth and neurodevelopment. A huge amount of researches indicates that the biological effects of human milk are dose dependent. Moreover, an increasing number of studies are showing that breast milk contains stem cells whose implications in infant neurodevelopment are under study. Hence, it is mandatory to promote initiation of breastfeeding as well as to support its duration [1][2][3][4].When taking into consideration feeding options for preterm infants, it should be highlighted that there is a biological hierarchy with milk of own mothers' being the first choice. When own mothers' milk is not available, donor human milk is recommended, whereas formula feeding should be the last choice [2].Human milk feeding represents a cost-effective strategy to reduce disease impact and associated costs in preterm infants, during the neonatal intensive care unit hospitalization [5]. Colaizy estimated that suboptimal feeding of extremely low birth weight infants would cost $27.1 million (CI $24 million, $30.4 million) in direct medical costs, $563,655 (CI $476,191, $599,069) in indirect nonmedical costs, and $1.5 billion (CI $1.3 billion, $1.6 billion) in cost attributable to premature death [6].The systematic review and meta-analysis published by Miller [7] summarized the available evidence in relation to the dose-dependent effect of human milk feeding on decreasing morbidity in infant born <28 weeks' gestation and/or birth weight <1500 g. Recent studies have assessed the different impact of human milk and preterm infant formula (PTF) feeding on one single outcome, thus limiting the in-depth analysis of the synergic protective co-effects led by the different nutritional and non-nutritional components of human milk against the most frequent comorbidities that affect premature infants. Remarkably, Miller considered the combination of five major morbidities (necrotizing enterocolitis, late onset sepsis, bronchopulmonary dysplasia, retinopathy of prematurity and neurodevelopment), pointing out the clear protective effect of human milk against necrotizing enterocolitis and possible reduction in late onset sepsis, severe retinopathy of prematurity and severe necrotizing enterocolitis. The comparison between various combinations of mixed feeding, human milk and preterm infant formula allowed for a specific investigation on the dose effect associated with human milk feeding.However, no conclusive evidence has been drawn on the incidence of bronchopulmonary dysplasia and on neurodevelopment, thus underlining the need for implementing research towards this direction.This systematic review allows for gaining further ins...

show abstract

mentioning

confidence: 99%

Human Milk Feeding in Preterm Infants: What Has Been Done and What Is to Be Done

2019

View full text Add to dashboard Cite

show abstract

“…Modern precision nutrition has, until recently, been applied almost exclusively to the field of sports performance and the management of chronic diseases in adults. Advances in metabolomics technologies, which detect small metabolites in body fluids, have informed how the interaction between environment, microbiota, and host genetics and epigenetics contribute to the effect of an individual's diet on energy utilization and disease status (19). Still, there exists an enormous need for an approach to nutrition science that fundamentally emphasizes the achievement of calculable outcomes for a specific stage of life, physiological event (e.g., postpartum and lactation), or environment.…”

Section: Supporting Lactation Successmentioning

confidence: 99%

Helping Mom Help Baby: Nutrition-Based Support for the Mother-Infant Dyad During Lactation

2020

View full text Add to dashboard Cite

Lactation and breastfeeding support the short-and long-term health of both mother and infant, yet the success of these processes depend upon individual and combined factors of the pair. Complications during pregnancy and delivery greatly affect the likelihood that a mother will be capable of breastfeeding for at least the recommended 6 months. Guidelines for women regarding postpartum diet and lifestyle management also fail to reflect the diversity of mother-infant pairs and their circumstances. In our analysis of the literature, we have identified a categorical deficit in modern scientific discourse regarding human lactation; namely, that postpartum involves full-body contribution of resources and thus requires the application of nutrition from a systemic perspective.

show abstract

“…During the last few years, the study of breast milk has focused on the analysis of micromolecular content, mainly on the immunological and inflammatory components (Gregory and Walker 2013), bioactive proteins (Lönnerdal 2013), glycoconjugates (Giuffrida et al 2014) and oligosaccharides (Underwood et al 2014). The mother's diet during lactation essentially influences the quality of the breast milk (Marincola et al 2015). For instance, cow's milk protein allergy in infants was shown to occur even during exclusive breast-feeding, if mother consumed cow's milk and/or derived products.…”

Section: Introductionmentioning

confidence: 99%

β-Lactoglobulin detected in human milk forms noncovalent complexes with maltooligosaccharides as revealed by chip-nanoelectrospray high-resolution tandem mass spectrometry

et al. 2015

View full text Add to dashboard Cite

Cow's milk protein allergy in exclusively breastfed infants, the main cause of food intolerance during the first 6 months of life, is triggered by the mother's diet. β-Lactoglobulin (BLG) present in cow's milk is one of the most potent allergens for newborns. Since no prophylactic treatment is available, finding ligands capable of binding BLG and reducing its allergenicity is currently the focus of research. In this work, an innovative methodology encompassing microfluidics based on fully automated chip-nanoelectrospray ionization (nanoESI), coupled with high-resolution mass spectrometry (MS) on a quadrupole time-of-flight (QTOF MS) instrument was developed. This platform was employed for the assessment of the noncovalent interactions between maltohexaose (Glc6) and β-lactoglobulin extracted from human milk upon deliberate intake of cow's milk. The experiments were carried out in (+) ESI mode, using ammonium acetate (pH 6.0) as the buffer and also in pure water. In both cases, the MS analysis revealed the formation of BLG-Glc6 complex, which was characterized by top-down fragmentation in tandem MS (MS/MS) using collision-induced dissociation (CID). Our findings have a significant biomedical impact, indicating that Glc6 binds BLG under conditions mimicking the in vivo environment and therefore might represent a ligand, able to reduce its allergenicity.

show abstract

Clinical impact of human breast milk metabolomics

Cited by 55 publications

References 26 publications

Human Milk Feeding in Preterm Infants: What Has Been Done and What Is to Be Done

Human Milk Feeding in Preterm Infants: What Has Been Done and What Is to Be Done

Helping Mom Help Baby: Nutrition-Based Support for the Mother-Infant Dyad During Lactation

β-Lactoglobulin detected in human milk forms noncovalent complexes with maltooligosaccharides as revealed by chip-nanoelectrospray high-resolution tandem mass spectrometry

Contact Info

Product

Resources

About