Clinical impact of pneumonia caused by Acinetobacter baumannii in intubated patients: A matched cohort study*

Garnacho, José; Solé‐Violán, Jordi; Sa-Borges, Marcio; Dı́az, Emili; Rello, Jordi

doi:10.1097/01.ccm.0000089936.09573.f3

Cited by 142 publications

(112 citation statements)

References 30 publications

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“…The significant factors for multidrug resistance in other studies were mechanical ventilation, multiple isolates, and neurologic impairment (Mahgoub et al, 2003;Deepha et al, 2011) debilitating chronic illness, postoperative surgical trauma, urinary catheterization (Joshi et al, 2006), parental nutrition, anemia and catheterization (Tripathi et al, 2104) A risk difference for sensitive and resistant isolates could not be established as sensitive strains in this study were very few (5.56%) Acinetobacter species infection is associated with increased morbidity and a prolonged length of hospital stay (Lisa et al, 2008) No significant difference in the length of stay between patients with resistant Acinetobacter species was observed in this study. This finding consistent with t other studies (Garnacho et al, 2003;Lisa et al, 2008). The length of stay in patients with resistant organisms may be confounded by their increased mortality.…”

Section: Following Antibiotics Were Tested In the Present Studysupporting

confidence: 82%

Analysis of Resistance Pattern of Acinetobacter Species in a Tertiary Care Hospital: A Retrospective Study

Chandak¹,

Loomba²,

Mishra³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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Section: Following Antibiotics Were Tested In the Present Studysupporting

confidence: 82%

Analysis of Resistance Pattern of Acinetobacter Species in a Tertiary Care Hospital: A Retrospective Study

Chandak¹,

Loomba²,

Mishra³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…Numerous studies have supported the observation that A. baumannii is the species most commonly involved in nosocomial infections such as pneumonia, wound infection, and bloodstream infection (4,7,15). The implication of A. baumannii in hospital outbreaks of nosocomial infection (8,10,29) has been attributed to their increasing antimicrobial resistance (21,39), and their ability to survive on inanimate and dry surfaces (2,24), both contributing to an increased survival time in the hospital environment.…”

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confidence: 96%

Development of a Multilocus Sequence Typing Scheme for Characterization of Clinical Isolates of Acinetobacter baumannii

et al. 2005

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In this study a multilocus sequence typing (MLST) scheme for Acinetobacter baumannii was developed and evaluated by using 40 clinical A. baumannii isolates recovered from outbreaks in Spanish and German hospitals during the years 1990 to 2001, as well as isolates from other European hospitals and two DSMZ reference strains of A. baumannii. For comparison, two isolates of Acinetobacter species 13 (sensu Tjernberg and Ursing), two clinical isolates, and three DSMZ strains of A. calcoaceticus (both belonging to the A. calcoaceticus-A. baumannii complex) were also investigated. Primers were designed for conserved regions of housekeeping genes, and 305-to 513-bp internal fragments of seven such genes-gltA, gyrB, gdhB, recA, cpn60, gpi, and rpoD-were sequenced for all strains. The number of alleles at individual loci ranged from 6 to 12, and a total of 20 allelic profiles or sequence types were distinguished among the investigated A. baumannii strains. The MLST data were in high concordance with the epidemiologic typing results generated by pulsed-field gel electrophoresis and amplified fragment length polymorphism fingerprinting. The MLST scheme provides a high level of resolution and an excellent tool for studying the population structure and long-term epidemiology of A. baumannii.

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“…Their contribution to nosocomial infections has increased over the past 3 decades, and many outbreaks involving these microorganisms have been reported worldwide (9). They particularly represent an important cause of ventilator-associated pneumonia (10,13) and catheter-related bacteremia (18,20,21,24,29). They are regularly recovered from urinary tract and wound infections, and some sporadic cases of peritoneal dialysis peritonitis, endocarditis, meningitis, osteomyelitis, arthritis, pancreatic and liver abscesses, and eye infections have also been reported (1,2,15).…”

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confidence: 99%

Bacterial Identification, Clinical Significance, and Antimicrobial Susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri , Two Frequently Misidentified Opportunistic Pathogens

et al. 2006

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The species belonging to the Acinetobacter genus are currently reported as opportunistic pathogens in hospitalized patients with underlying predispositions. However, except for the Acinetobacter calcoaceticusAcinetobacter baumannii complex, the identification of other species is frequently unreliable, especially for Acinetobacter ursingii and Acinetobacter schindleri, newly described in 2001. Thus, the clinical significance, phenotypic features, and antimicrobial susceptibilities of these two misidentified species remain unclear. Of 456 Acinetobacter sp. clinical strains isolated from 2002 to 2005 in Henri Mondor Hospital, 15 isolates (10 A. ursingii and 5 A. schindleri isolates) were studied. They were characterized using a phenotypic approach (API 20 NE and VITEK 2 systems), 16S rRNA gene sequencing, and susceptibility to antimicrobial agents with evaluation of impact in clinical relevance. The two corresponding type strains were also included for comparison. All isolates were identified to the species level using molecular tools, whereas the phenotypic methods remained unreliable due to the absence of these two species in the manufacturers' databases. However, the API 20 NE system appeared to be a reasonably reliable phenotypic alternative for the identification of A. ursingii when the numerical code 0000071 was found. Conversely, no discriminative phenotypic alternative existed for A. schindleri isolates. Concerning antimicrobial susceptibility, A. ursingii strains appeared to be more resistant to antibiotics than A. schindleri strains, which could imply therapeutic consequences. Finally, the prevalence of infections caused by A. ursingii and A. schindleri (representing 9.7% and 4.8% of non-A. calcoaceticus-A. baumannii complex strains, respectively) seems to be underestimated.

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Clinical impact of pneumonia caused by Acinetobacter baumannii in intubated patients: A matched cohort study*

Abstract: In intubated patients, pneumonia by A. baumannii is not significantly associated with attributable mortality rate or an increased length of intensive care unit stay.

Cited by 142 publications

References 30 publications

Analysis of Resistance Pattern of Acinetobacter Species in a Tertiary Care Hospital: A Retrospective Study

Analysis of Resistance Pattern of Acinetobacter Species in a Tertiary Care Hospital: A Retrospective Study

Development of a Multilocus Sequence Typing Scheme for Characterization of Clinical Isolates of Acinetobacter baumannii

Bacterial Identification, Clinical Significance, and Antimicrobial Susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri , Two Frequently Misidentified Opportunistic Pathogens

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