Clinical Impact of Sarcopenia on Gastric Cancer

Kuwada, Kazuya; Kuroda, Shigetoshi; Kikuchi, Shinichi; Yoshida, Ryuichi; Nishizaki, Masahiko; Kagawa, Shunsuke; Fujiwara, Toshiyoshi

doi:10.21873/anticanres.13340

Cited by 81 publications

(61 citation statements)

References 67 publications

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“…Our previous report showed that the whole psoas volume was correlated with psoas area at the L3 level [2]. The present study revealed that a low PMI was associated with a poorer prognosis than a high PMI in penile cancer, findings that concurred with those of previous reports in other solid malignancies [8,[11][12][13][14]. However, our study did not describe the correlation between a lower PNI and other prognostic factors, including the pathological grade, T stage, Broders' grade, and Y-K grade [19,20].…”

Section: Discussionsupporting

confidence: 92%

“…Sarcopenia lowers the performance status and increases the prevalence of neurologic disease, chronic lung diseases, and virus infection [9,10]. Recent studies have revealed that a low PMI was associated with a poorer prognosis than a high PMI, including for cases of gastrointestinal, genitourinary, and gynecological cancers [8,[11][12][13][14]. However, no report has described the correlation between sarcopenia and penile cancer.…”

Section: Discussionmentioning

confidence: 99%

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A low psoas muscle volume is associated with a poor prognosis in penile cancer

et al. 2020

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Background: Sarcopenia was initially recognized as a marker representing the nutritional condition or aging. Recently, sarcopenia has been associated with a poor prognosis and postoperative complications. We examined the importance of sarcopenia as a predictive marker of the prognosis in penile cancer. Materials and Methods: A total of 25 patients diagnosed with penile cancer who underwent penile resection from 2000 to 2010 were analyzed in this study. The psoas muscle index (PMI) was calculated based on psoas area using preoperative axial computed tomography images at the right L3 level divided by the square of the body height. Results: Nineteen (76.0%) patients underwent partial penectomy, and 6 (24.0%) underwent total penectomy. The median (mean ± standard deviation) age was 69.3 (69.0 ± 10.1) years old. Regarding the site of penile cancer, 17 (76.0%) cases were in the glans, 6 (24.0%) were in the foreskin, and 2 (8.0%) were in the shaft. Lymph node metastasis were seen in 6 cases (24.0%), and distant metastasis was seen in 1 case (4.0%). The lower PMI group (< 320.0) showed a significantly poorer progression-free survival than the higher PMI group (≥ 320.0) (p = 0.030), although no significant difference in the overall survival was noted (p = 0.076). Conclusions: Sarcopenia might be a useful prognostic factor in penile cancer patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A low psoas muscle volume is associated with a poor prognosis in penile cancer

et al. 2020

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“…Recently, sarcopenia as defined by low skeletal muscle mass and low skeletal muscle function has been gaining much interest due to its prognostic impact in cancer patients [36][37][38][39]. A recent meta-analysis regarding outcome in PaC patients receiving surgery reported that sarcopenia was associated with increased peri-operative mortality and decreased OS [37].…”

Section: Discussionmentioning

confidence: 99%

Proposal of predictive model on survival in unresectable pancreatic cancer receiving systemic chemotherapy

et al. 2020

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Aims:To construct a predictive model for overall survival (OS) in unresectable pancreatic cancer (PaC) undergoing systemic chemotherapy and to confirm its accuracy in an independent cohort. Patients and methods: The training set (Ts) and the validation set (Vs) included 93 patients (median age=71 years) and 75 patients (median age=76 years). In the Ts, we examined variables linked to OS by uni-and multivariate analyses and constructed a predictive model for OS. Next, we evaluated the reproducibility of the proposed model in the Vs. Results: In the multivariate analysis for the Ts, PaC stage IV (P=0.0020) and carbohydrate antigen (CA) 19-9 >437.5 IU/l (P=0.0237) were identified to be significant factors associated with OS. Patients with PaC stage IV or not were given a score of 1 or 0, whereas patients with CA19-9 >437.5 IU/l or <437.5 IU/l were given a score of 1 or 0. Sum of the point of PaC stage (0 or 1) and CA19-9 (0 or 1) was defined as "PaC-CA score". In the Ts, there were 16 patients with score 0, 40 with score 1 and 37 with score 2, while in the Vs, there were 9 patients with score 0, 32 with score 1 and 34 with score 2. Overall P values reached significance in the Ts (P=0.0002), the Vs (P=0.0029) and the combined Ts and Vs (P<0.0001) among patients with PaC score 0, 1 and 2. Conclusion: PaC-CA score can be helpful for risk stratification in PaC patients undergoing systemic chemotherapy.

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“…However, many aspects of sarcopenia in gastric cancer are still to be elucidated, particularly in the Western population, as most previous observations were obtained from Asian countries. 2,3 The optimum method of diagnosing sarcopenia, as emphasized by Safer and colleagues, is the combination of low muscle mass and impaired muscle function and/or reduced physical performance. 4 However, few previous reports adopted this gold standard to prospectively evaluate cancer patients.…”

Section: Sarcopenia Associated With Gastric Cancermentioning

confidence: 99%

“…This is of particular importance in the population of gastric cancer patients due to the high prevalence of malnutrition and muscle weight loss. However, many aspects of sarcopenia in gastric cancer are still to be elucidated, particularly in the Western population, as most previous observations were obtained from Asian countries …”

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confidence: 99%