Clinical Impact of Sarcopenia on Cholangiocarcinoma

Shin, Suk Pyo; Koh, Dong Hee

doi:10.3390/life12060815

Cited by 4 publications

(3 citation statements)

References 75 publications

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“…Our findings also support those of previous studies, as we showed that sarcopenia was associated with increased operation time, intraoperative blood loss, packed RBC transfusion, and poor overall short-term prognosis ( 29 , 39 ). Moreover, sarcopenia showed poor OS which was consistent with findings of previous studies, while we did not observe any relevance to RFS ( 38 ). It can be interpreted that our cut-off was based on the ROC curve analysis of ICU admission.…”

Section: Discussionsupporting

confidence: 92%

“…In particular, frequent obstructive jaundice in patients with Klatskin tumors makes them vulnerable to poor oral intake and decreased activity, which consequently induce sarcopenia ( 36 , 37 ). Among many previous definitions, the cut-offs for diagnosing sarcopenia for Klatskin tumor differed depending on the studies (range of PMI cut-off for men: 4.77 – 8.60 cm²/m² and for women: 3.38 – 6.04 cm²/m²) ( 38 ). We used the normalised PMA which is widely used to diagnose sarcopenia, and the cut-off value was determined by ROC curve analysis by taking the rate of ICU admission as an indicator for predictive validity to determine the optimal cut-off value for each sex (6.74 cm²/m² for men and 3.39 cm²/m² for women).…”

Section: Discussionmentioning

confidence: 99%

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Effect of sarcopenia on postoperative ICU admission and length of stay after hepatic resection for Klatskin tumor

Jung

Han²,

Koo³

et al. 2023

Front. Oncol.

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BackgroundHepatic resection of Klatskin tumors usually requires postoperative intensive care unit (ICU) admission because of its high morbidity and mortality. Identifying surgical patients who will benefit most from ICU admission is important because of scarce resources but remains difficult. Sarcopenia is characterised by the loss of skeletal muscle mass and is associated with poor surgical outcomes.MethodsWe retrospectively analysed th.e relationship between preoperative sarcopenia and postoperative ICU admission and length of ICU stay (LOS-I) in patients who underwent hepatic resection for Klatskin tumors. Using preoperative computed tomography scans, the cross-sectional area of the psoas muscle at the level of the third lumbar vertebra was measured and normalised to the patient’s height. Using these values, the optimal cut-off for diagnosing sarcopenia was determined using receiver operating characteristic curve analysis for each sex.ResultsOf 330 patients, 150 (45.5%) were diagnosed with sarcopenia. Patients with preoperative sarcopenia presented significantly more frequently to the ICU (77.3% vs. 47.9%, p < 0.001) and had longer total LOS-I (2.45 vs 0.89 days, p < 0.001). Moreover, patients with sarcopenia showed a significantly higher postoperative length of hospital stay, severe complication rate, and in-hospital mortality.ConclusionsSarcopenia correlated with poor postoperative outcomes, especially with the increased requirement of postoperative ICU admission and prolonged LOS-I after hepatic resection in patients with Klatskin tumors.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Effect of sarcopenia on postoperative ICU admission and length of stay after hepatic resection for Klatskin tumor

Jung

Han²,

Koo³

et al. 2023

Front. Oncol.

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“…Hilar cholangiocarcinoma is the main type of extrahepatic cholangiocarcinoma, accounting for 58% to 75% [ 19 , 20 ]. Due to the special location of the disease and the characteristics of early invasion of blood vessels, nerves, lymphoid tissues and adjacent liver tissues, the operation for hilar cholangiocarcinoma is more difficult and complex [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort

Zhang

Qi²,

Sun³

et al. 2022

Eur J Med Res

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Background Biliary fistula is a common but serious complication after radical resection of hilar cholangiocarcinoma. We aimed to evaluate the influencing factors of biliary fistula after radical resection, to provide insights to the clinical treatment of hilar cholangiocarcinoma. Methods Patients undergoing radical resection of hilar cholangiocarcinoma from January 1, 2015 to March 31, 2022 were selected. Patients’ personnel characteristics and laboratory test results of patients with and without biliary fistula were collected and compared. Logistic regression analyses were conducted to evaluate the associated risk factors of biliary fistula. Results 160 patients undergoing radical resection of hilar cholangiocarcinoma were included, the incidence of postoperative biliary fistulas was 20.63%. There were significant differences in the age, preoperative cholangitis and number of biliary anastomosis between biliary fistula and no biliary fistula patients (all p < 0.05). There were significant differences in the gamma glutamyl transpeptidase (GGT) on the first day after surgery, Klebsiella pneumoniae between biliary fistula and no biliary fistula patients (all p < 0.05). Logistic regression analysis indicated that age ≥ 65 years (OR 2.035, 95%CI 1.131–3.007), preoperative cholangitis (OR 1.584, 95% CI 1.081–2.361), number of biliary anastomosis ≥ 2(OR 2.866, 95%CI 1.942–3.624), GGT on the first day after surgery ≥ 120 U/L (OR 1.823, 95%CI: 1.274–2.906), preoperative bile culture for Klebsiella pneumoniae (OR 3.181, 95%CI: 2.426–3.992) were the risk factors of postoperative biliary fistulas (all p < 0.05). Conclusions There are many independent risk factors for postoperative biliary fistula in patients undergoing radical resection of hilar cholangiocarcinoma. Clinical medical workers should take early interventions and treatment measures for these high-risk patients to reduce the occurrence of postoperative biliary fistula.

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Albumin-myosteatosis gauge as a prognostic factor in patients with advanced pancreatic cancer undergoing first-line chemotherapy

Sahin,

Ozbay,

Altunbulak

et al. 2024

Int J Clin Oncol

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Clinical Impact of Sarcopenia on Cholangiocarcinoma

Cited by 4 publications

References 75 publications

Effect of sarcopenia on postoperative ICU admission and length of stay after hepatic resection for Klatskin tumor

Effect of sarcopenia on postoperative ICU admission and length of stay after hepatic resection for Klatskin tumor

Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort

Albumin-myosteatosis gauge as a prognostic factor in patients with advanced pancreatic cancer undergoing first-line chemotherapy

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