Clinical Impact of the Cardio-Ankle Vascular Index for Predicting Cardiovascular Events After Acute Coronary Syndrome

Gohbara, Masaomi; Iwahashi, Noriaki; Sano, Yuka; Akiyama, Eiichi; Maejima, Nobuhiko; Tsukahara, Kengo; Hibi, Kiyoshi; Kosuge, Masami; Ebina, Toshiaki; Umemura, Satoshi; Kimura, Kazuo

doi:10.1253/circj.cj-15-1257

Cited by 49 publications

(47 citation statements)

References 26 publications

(13 reference statements)

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“…A total of 70 articles on baPWV 15 , 24 – 27 , 43 – 107 and 15 articles on CAVI 16 , 24 – 28 , 108 – 116 were identified. Table 1 presents a summary of these articles.…”

Section: Resultsmentioning

confidence: 99%

“…As such, that study was excluded from the statistical analysis as a baPWV article because the independent prognostic significance of baPWV for the primary end point was not clarified. 28 Moreover, because of the relatively ample number of baPWV articles, the studies with or without the clarified exclusion criteria of LE-ASO/PAD only among baPWV articles were compared to confirm the effect on success rate. Furthermore, multivariate logistic regression analysis was performed to explore the independent factors of the success of prognostic prediction.…”

Section: Methodsmentioning

confidence: 99%

“…However, a statistical analysis was not performed among the five articles that simultaneously studied baPWV and CAVI because of the too small sample and of the heterogeneity in the condition. 24 – 28 Moreover, logistic regression analysis was performed to explore the independent determinants of the success of prognostic prediction (success =1, failure =0). The following covariates were analyzed in the univariate analysis: baPWV or CAVI (baPWV =1, CAVI =0), presence of the clarified exclusion criteria of LE-ASO/PAD (yes =1, no =0), dialysis population (yes =1, no =0), follow-up period (years), age (years), male gender (%) in the study cohort, and log-transformed number of patients (log NoP).…”

Section: Methodsmentioning

confidence: 99%

“…Five articles reported the prognostic significance of baPWV and CAVI in the same population. 24 – 28 However, no studies have comprehensively discussed the differences in prognostic predictability among those indices. 29 Therefore, this study aimed to identify articles that researched the prognostic predictability of both indices and compare the success rate wholly and in each category.…”

Section: Introductionmentioning

confidence: 99%

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Brachial–ankle pulse wave velocity, cardio-ankle vascular index, and prognosis

Ato¹

2018

VHRM

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BackgroundBrachial–ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are indices of arterial stiffness, and several studies have used these indices. However, there is no comprehensive review of these parameters in the prognostic significance.MethodsThe aim of this study was to review the articles exploring the prognostic significance of these parameters. Articles demonstrating independent significance after multivariate analysis on the Cox proportional hazards model were defined as “successful.” The success rate was compared using Fisher’s exact test. In addition, multivariate logistic regression analysis was performed to explore the independent determinants of the success of prognostic prediction.ResultsThe success rate of the baPWV articles (65.7% [46/70]) tended to be higher than that of the CAVI articles (40.0% [6/15]; P=0.083). Multivariate analysis demonstrated that log (number of patients) (OR 11.20, 95% CI 2.45–51.70, P=0.002) and dialysis population (OR 0.28, 95% CI 0.08–0.94, P=0.039) were positive and negative independent determinants of the success of prognostic prediction, respectively. In addition, after redefining two studies as the absence of arteriosclerosis obliterans (ASO) exclusion, baPWV (OR 3.36, 95% CI 0.86–13.20, P=0.083) and the existence of exclusion criteria of ASO (OR 3.08, 95% CI 0.96–9.93, P=0.060) exhibited statistical tendency in the multivariate analysis.ConclusionThis study demonstrated that the number of study participants and dialysis population were the independent determinants of the success of prognostic prediction. This study also showed the importance of exclusion criteria of ASO when using these indices. In addition, a prospective large-scale study to confirm the superiority in the prognostic prediction of these indices is warranted.

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“…A total of 70 articles on baPWV 15 , 24 – 27 , 43 – 107 and 15 articles on CAVI 16 , 24 – 28 , 108 – 116 were identified. Table 1 presents a summary of these articles.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Brachial–ankle pulse wave velocity, cardio-ankle vascular index, and prognosis

Ato¹

2018

VHRM

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“…The cardio-ankle vascular index (CAVI) is a novel physiological marker of arteriosclerosis that reflects the stiffness of the aorta and the femoral and tibial arteries and is not affected by blood pressure measurements [7]. A number of clinical studies have revealed the importance of the CAVI as a marker for cardiovascular risk factors [8][9][10][11], and other groups have documented significant relationships between the CAVI and markers of renal function such as eGFR and urinary albumin concentration [12,13]. Taken together, these results suggest that the CAVI provides a reflection of renal hemodynamics.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between the Cardio-Ankle Vascular Index and Renal Resistive Index in Patients With Essential Hypertension

Hatori¹

2020

Cardiol Res

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Background: Renal resistive index (RRI) is a parameter determined by Doppler sonography that reflects renal hemodynamics. Significant relationships connecting increases in the RRI with cardiovascular risk factors and the incidence of cardiovascular disease in hypertensive patients have been reported. This cross-sectional study aimed to clarify the relationship between cardio-ankle vascular index (CAVI), a novel marker of arterial stiffness, and the RRI in patients with essential hypertension with the goal of primary prevention of cardiovascular disease. Methods: The study included 245 patients undergoing treatment for essential hypertension (95 men and 150 women; mean age ± standard deviation, 65 ± 13 years) with no history of cardiovascular disease. The CAVI and RRI were measured using commercial devices, and their relationships to various clinical parameters were examined. Results: A significant positive correlation was observed between the CAVI and RRI (r = 0.43, P < 0.001). Multiple regression analyses revealed a value of β of 0.28 (P < 0.001) when CAVI was evaluated as the independent and RRI as the dependent variable. Receiver-operating characteristic curve analysis indicated that the CAVI cutoff point for high RRI (> 0.70) was 9.0 with area under the curve of 0.700 (P < 0.001). Conclusion: The results from this study indicate that the CAVI varies directly with measures of renal vascular hemodynamics (RRI) in patients with essential hypertension. These findings identified a cardiovascular risk value of the CAVI from the perspective of renal hemodynamics as 9.0 in this patient population.

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Aortic arch calcification with pericardial fat mass detected on a single chest X-ray image is closely associated with the predictive variables of future cardiovascular disease

et al. 2021

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This study evaluated the associations between aortic arch calcification (AAC) with pericardial fat (PF) mass detected on a single chest X-ray image and predictive variables of future cardiovascular disease (CVD). The subjects were 353 patients treated with at least one of the hypertension, dyslipidemia or diabetes. All subjects were evaluated for AAC; divided into 3 groups with AAC grades of 0, 1, or 2; and examined for the presence of PF. Carotid intima-media thickness (IMT, n = 353), cardio-ankle vascular index (CAVI, n = 218), the Suita score (n = 353), and cardiovascular risk points defined in the Hisayama study (n = 353), an assessment of the risk of future cardiovascular disease, were measured. The relationship of AAC grades, with or without PF, and CVD risks was evaluated.

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Clinical Impact of the Cardio-Ankle Vascular Index for Predicting Cardiovascular Events After Acute Coronary Syndrome

Cited by 49 publications

References 26 publications

Brachial–ankle pulse wave velocity, cardio-ankle vascular index, and prognosis

Brachial–ankle pulse wave velocity, cardio-ankle vascular index, and prognosis

Correlation Between the Cardio-Ankle Vascular Index and Renal Resistive Index in Patients With Essential Hypertension

Aortic arch calcification with pericardial fat mass detected on a single chest X-ray image is closely associated with the predictive variables of future cardiovascular disease

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Clinical Impact of the Cardio-Ankle Vascular Index for Predicting Cardiovascular Events After Acute Coronary Syndrome

Cited by 49 publications

References 26 publications

Brachial&ndash;ankle pulse wave velocity, cardio-ankle vascular index, and prognosis

Brachial&ndash;ankle pulse wave velocity, cardio-ankle vascular index, and prognosis

Correlation Between the Cardio-Ankle Vascular Index and Renal Resistive Index in Patients With Essential Hypertension

Aortic arch calcification with pericardial fat mass detected on a single chest X-ray image is closely associated with the predictive variables of future cardiovascular disease

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Brachial–ankle pulse wave velocity, cardio-ankle vascular index, and prognosis

Brachial–ankle pulse wave velocity, cardio-ankle vascular index, and prognosis