Clinical Impact of Tumor-Infiltrating Inflammatory Cells in Primary Small Cell Esophageal Carcinoma

Zhang, Yuling; Ren, Hongzheng; Wang, Lu; Ning, Zhifeng; Zhuang, Yingping; Gan, Jinfeng; Chen, Shaobin; Zhou, David; Zhu, Hua; Tan, Dongfeng; Zhang, Hao

doi:10.3390/ijms15069718

Cited by 29 publications

(23 citation statements)

References 60 publications

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“…However, in addition to their important role in fighting infections and inflammation, they play a critical role in the development of effective antitumor immunity (31). The infiltration of neutrophils and/or eosinophils in colorectal and primary small cell esophageal carcinoma was found to be associated with a good prognosis and enhanced survival of patients (32)(33)(34). Studies using in vivo models reported that tumor-homing neutrophils and/or eosinophils were essential for tumor rejection by initiation of changes in the tumor microenvironment (35)(36)(37).…”

Section: Antitumor Effect Of the Combination Of Manumycin A Andmentioning

confidence: 99%

Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model

et al. 2016

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Manumycin A is a natural antibiotic isolated from Streptomyces parvulus with broad range of biological activities including antineoplastic activity in several in vitro and in vivo cancer models. Immodin [dialyzable leukocyte extract (DLE)] is a dialysate released from disintegrated blood leukocytes of healthy donors which exerts immunonormalizing effects on cell-mediated immune responses. The aim of the present study was to explore the antitumor potential of the combination of manumycin A and Immodin in an experimental breast cancer model. Experiments were carried using a 4T1 tumor-bearing BALB/c mouse model. Survival analysis, tumor growth, hematological and biochemical profiles, leukocyte differential, phagocytic activity of leukocytes and histology of the primary tumor were examined. The combination treatment suppressed the tumor growth and prolonged the survival of tumor-bearing mice, decreased the number of monocytes, plateletes and plateletcrit in peripheral blood of the tumor-bearing mice and increased the infiltration of neutrophils and eosinophils in the primary tumor. Moreover, individual therapies enhanced the phagocytic activity of monocytes and neutrophils. These findings demonstrate the antitumor effect of the combination of manumycin A and Immodin in 4T1 tumor-bearing mice associated with strong antiplatelet activity and innate immunity activation.

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Section: Antitumor Effect Of the Combination Of Manumycin A Andmentioning

confidence: 99%

Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model

et al. 2016

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“…Esophageal squamous cell carcinoma (ESCC) is the third most common malignancy of the digestive tract and the fifth leading cause of cancer‐related death worldwide . The prognosis of ESCC remains to be poor with 5‐year survival rate <20% .…”

Section: Introductionmentioning

confidence: 99%

“…2 Esophageal squamous cell carcinoma (ESCC) is the third most common malignancy of the digestive tract and the fifth leading cause of cancer-related death worldwide. [29][30][31][32][33][34][35][36] The prognosis of ESCC remains to be poor with 5-year survival rate <20%. [37][38][39][40][41] In this study, we found that NCOA1 is highly enriched in human ESCC, and the levels of NCOA1 are clinically important in ESCC progression and patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma

Wang

et al. 2018

Cancer Medicine

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Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene expression mediated by a wide spectrum of steroid receptors such as androgen receptor (AR), estrogen receptor α (ER α), and estrogen receptor β (ER β). Therefore, dysregulations of NCOA1 have been found in a variety of cancer types. However, the clinical relevance and the functional roles of NCOA1 in human esophageal squamous cell carcinoma (ESCC) are less known. We found in this study that elevated levels of NCOA1 protein and/or mRNA as well as amplification of the NCOA1 gene occur in human ESCC. Elevated levels of NCOA1 due to these dysregulations were not only associated with more aggressive clinic‐pathologic parameters but also poorer survival. Results from multiple cohorts of ESCC patients strongly suggest that the levels of NCOA1 could serve as an independent predictor of overall survival. In addition, silencing NCOA1 in ESCC cells remarkably decreased proliferation, migration, and invasion. These findings not only indicate that NCOA1 plays important roles in human ESCC but the levels of NCOA1 also could serve as a potential prognostic biomarker of ESCC and targeting NCOA1 could be an efficacious strategy in ESCC treatment.

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“…SCCE is a highly aggressive disease characterized by rapid progression, extensive metastasis and poor prognosis, with a higher incidence of males than females (7)(8)(9)(10). At present, some studies have found a number of clinicopathological indicators that can assess the prognosis of SCCE, including lesions, TNM stage, VALSG stage, tumor inflammatory cell infiltration and treatment, but the results from some of these literatures are controversial (11)(12)(13)(14)(15). Therefore, it is necessary to explore new indicators that can evaluate the prognosis in order to improve the existing prognostic model and achieve a more accurate and comprehensive assessment of SCCE.…”

Section: Introductionmentioning

confidence: 99%

ApoB/ApoA-1 Ratio as a Novel Prognostic Predictor in Patients With Primary Small Cell Carcinoma of the Esophagus

Chen

Chu

et al. 2020

Front. Oncol.

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Background and Aim: Primary small cell carcinoma of the esophagus (SCCE) is a rarely aggressive disease characterized by rapid progression, widespread metastasis, and poor prognosis. This study was aimed to evaluate the prognostic significance of serum lipids for overall survival (OS) in SCCE patients. Methods: We retrospectively analyzed SCCE patients in a training cohort (61 patients) and validated them in a validation cohort (27 patients). These cases were collected from Sun Yat-sen University Cancer Center from 2006 to 2017. Univariate and multivariate Cox survival analyses were performed to determine serum lipids as prognostic factors associated with the patient's OS. Time-dependent receiver operating characteristics (ROC) were used to compare predictive power of independent prognostic factors. The predictive accuracy and discriminative ability of the prognostic factors were measured by the concordance index (C-index) and decision curve, and were compared with the TNM stage system. Results: On multivariate analysis of the training cohort, independent factors for survival were gender, BAR (ApoB/ApoA-1) and TNM stage. The area under the curve (AUC) of BAR+TNM stage in the training cohort was higher than that of TNM stage for OS, and similar result was observed in the validation cohort. The c-index of BAR+TNM stage for predicting the OS was 0.655 (95% CI = 0.571-0.740), which was higher than that of TNM stage [0.614 (95% CI = 0.530-0.698)] in the training cohort. In the validation cohort, the C-index of the BAR+TNM stage for predicting OS was also higher than that of the TNM stage [0.688 (95% CI: 0.570∼0.806) vs. (0.512; 95% CI: 0.392∼0.632)]. In addition, decision curve analysis also showed that the predictive accuracy of BAR+TNM stage for OS was higher than TNM stage both in the training and the validation cohorts. Conclusions: BAR represents a promising prognostic indicator that might complement TNM stage in the prognosis of SCCE, and that warrant further assessment in large SCCE patient cohort.

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Clinical Impact of Tumor-Infiltrating Inflammatory Cells in Primary Small Cell Esophageal Carcinoma

Cited by 29 publications

References 60 publications

Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model

Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model

The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma

ApoB/ApoA-1 Ratio as a Novel Prognostic Predictor in Patients With Primary Small Cell Carcinoma of the Esophagus

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