Clinical implication of leucine zipper/EF hand-containing transmembrane-1 overexpression in the prognosis of triple-negative breast cancer

Wang, Changan; Liu, Qixiang; Chen, Yunbo; Liu, Shuangping; Xu, Jianlin; Cui, Xia; Zhang, Yan; Li, Piao

doi:10.1016/j.yexmp.2014.12.012

Cited by 16 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, some authors have claimed that high expression levels of LETM1 have correlation with poor prognostic factors in human malignancies [19, 20]. In our study, compatible to previous knowledge, the correlation analysis using GeneNetwork indicated that Letm1 mRNA expression levels had strong positive correlation with mRNA expressions of genes related to OxPhos such as Ndufv1, Sdhb, Cyc1, Atp5b and so forth.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation

Lee

Seol

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Persistent cellular proliferation and metabolic reprogramming are essential processes in carcinogenesis. Here, we performed Gene Set Enrichment Analysis (GSEA) and found that that LETM1, a mitochondrial calcium transporter, is associated with cellular growth signals such as platelet-derived growth factor (PDGF) receptor signaling and insulin signaling pathways. These results were then verified by qRT-PCR and immnunoblotting. Mechanistically, up-regulation of LETM1 induced YAP1 nuclear accumulation, increasing the expression of PDGFB, PDGFRB and THBS4. Consistent with this, LETM1 silencing caused loss of YAP1 nuclear signal, decreasing the expression of PDGFB, PDGFRB and THBS4. Immunohistochemical staining consistently indicated a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression. In clinical data analysis, LETM1 up-regulation in thyroid cancer was found to be related to aggressive tumor features such as lymphovascular invasion (LVI, P < 0.001) and lymph node metastasis (LNM, P = 0.011). Multivariate analysis demonstrated that LETM1 up-regulation increases the risk of LVI and LNM (OR = 3.455, 95% CI = 1.537–7.766 and OR = 3.043, 95% CI = 1.282–7.225, respectively). Collectively, these data suggest that up-regulation of LETM1 induces sustained activation of proliferative signaling pathways, such as PDGF signal pathway by AKT induced YAP1 transactivation, resulting in aggressive thyroid cancer phenotypes.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Furthermore, LETM1 promotes AKT/PKB activation by inhibition of C-terminal modulator protein (CTMP) [18]. Supporting the proto-oncogenic properties of LETM1, human multiple tissues arrays have also demonstrated increased expression of LETM1 in various cancers, including breast, head and neck cancers [19, 20]. …”

Section: Introductionmentioning

confidence: 99%

Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation

Lee

Seol

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…For example, Chen et al reported that LETM1 was highly expressed in head and neck squamous cell carcinoma and that a high expression of LETM1 predicts poor prognosis (9). Another study revealed that high LETM1 expression was positively correlated with late clinical stage, poor differentiation, lymph node metastasis, disease-free survival and 10-year overall survival rates in triple-negative breast cancer (10). However, the role of LETM1 in human bladder cancer have yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Suppression of LETM1 by siRNA inhibits cell proliferation and invasion of bladder cancer cells

Huang

Zhang

et al. 2017

Oncology Reports

View full text Add to dashboard Cite

The leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is highly expressed in many human malignancies and is correlated with poor prognosis. However, the function of LETM1 in bladder cancer still remains unknown. In the present study, we analyzed the expression levels of LETM1 in bladder cancer tissues and non-cancerous tissues as well as in four bladder cancer cell lines (T24, EJ, 5637 and J82) and a human bladder epithelial immortalized cell line SV-HUC-1. Small interfering RNA (siRNA) was employed to knockdown the expression of LETM1 in the T24 cells. The proliferation of T24 cells was significantly repressed as evaluated by CCK-8 assays. Transwell migration and invasion assays indicated that knockdown of LETM1 suppressed cell migration and invasion significantly. Flow cytometric analysis revealed that cells had accumulated at the S-phase when the expression of LETM1 was suppressed. Moreover, we found that several oncogenic proteins in the Wnt/β-catenin signaling pathway, namely β-catenin, cyclin D1 and c-Myc were significantly decreased by the LETM1 siRNA. Collectively, these results revealed that the knockdown of LETM1 exhibited tumor suppressive effects, possibly by controlling the downstream Wnt/β-catenin signaling pathway.

show abstract

“…LETM1 ha sido relacionado con el desarrollo del cáncer escamoso de cabeza y cuello (Chen et al, 2014b), así como con el cáncer de mama triple negativo (Wang et al, 2015a).…”

Section: Intercambiadores Mitocondriales De Ca 2+unclassified

“…Además, parece ser importante en la progresión del cáncer de escamoso de cara y cuello, ya que el incremento de su expresión está relacionada con un peor pronóstico del mismo (Chen et al, 2014b). También, la sobreexpresión de LETM1 ha sido asociada con la progresión del cáncer de mama triple negativo, así como con un peor pronóstico de la enfermedad (Wang et al, 2015a).…”

Section: Transporte De Ca 2+ En La Mitocondria Y Cáncerunclassified

Remodelado del Ca2+ Intracelular en el cáncer colorrectal: descripción, bases moleculares y consecuencias funcionales

Luengo¹

View full text Add to dashboard Cite

show abstract

Clinical implication of leucine zipper/EF hand-containing transmembrane-1 overexpression in the prognosis of triple-negative breast cancer

Cited by 16 publications

References 27 publications

Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation

Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation

Suppression of LETM1 by siRNA inhibits cell proliferation and invasion of bladder cancer cells

Remodelado del Ca2+ Intracelular en el cáncer colorrectal: descripción, bases moleculares y consecuencias funcionales

Contact Info

Product

Resources

About