Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

Bertinazzi, Martina; Gheit, Tarik; Polesel, Jerry; McKay‐Chopin, Sandrine; Cutrone, Cesare; Sari, Marianna; Sbaraglia, Marta; Tos, Angelo Paolo Dei; Nicolai, Piero; Tommasino, Massimo; Boscolo‐Rizzo, Paolo

doi:10.1007/s00405-021-07040-9

Cited by 7 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HPV6 and HPV11 remained the two most predominant genotypes, and there was no co-infection with HR-HPV in our cases. The most frequent type was LR-HPV11, which represents the most prevalent HPV in laryngeal lesions, and HPV11 was found to be more prevalent in children than in adults [14]. It seems that children are more prone to compound infection and 3/28 (10.8%) cases were positive for multiple HPV types among our JO-RRP cases, which may explain the high recurrence rate in children with severe symptoms.…”

Section: Plos Onementioning

confidence: 74%

Analysis of the anatomical distribution of HPV genotypes in head and neck squamous papillomas

Jiang

Zhang

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Squamous papillomas (SPs) of the head and neck are usually benign lesions associated with human papilloma virus (HPV) infection. However, the reported HPV detection rates vary widely, especially with respect to anatomical distribution. The etiology of SPs in the head and neck remains unclear; analyzing HPV genotypes of SPs based on anatomical sites could assist in clarifying the pathogenesis of SPs in the head and neck. Therefore, the aim of this study was to review the prevalence, subtypes, and anatomical distribution of HPV in head and neck SPs at a hospital in China; we also investigated whether p16, a marker of HPV infection in oropharyngeal carcinoma, could serve as a surrogate marker for HPV in head and neck SPs. The presence of HPV DNA of 23 types (5 low-risk HPV and 18 high-risk HPV types) was detected via real-time PCR. p16 immunohistochemistry was performed using SP sections. Age, sex, anatomical location, and HPV subtype were recorded for each case. In total, 105 SPs were identified, including 47 in the larynx, 42 in the pharynx, 6 in the external auditory canal (EAC), 5 in the oral cavity, and 5 in the nasal cavity. HPV was found in 57 (54.3%) cases, with the highest positivity rate in the larynx (46/47; 97.9%). Only 5/42 (11.9%) patients showed HPV positivity in the pharynx. HPV incidence was highly dependent on the anatomical site. SPs in the larynx and EAC were more likely to carry HPV than those in other anatomical sites. High-risk HPV infections were rarely associated with SPs in the head and neck region. The sensitivity and specificity of p16 immunohistochemistry for HPV infection were 88% and 96%, respectively. There may be an association between p16 and HPV infection in head and neck SPs, but further studies are needed to validate this assertion.

show abstract

Section: Plos Onementioning

confidence: 74%

Analysis of the anatomical distribution of HPV genotypes in head and neck squamous papillomas

Jiang

Zhang

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…This disease is frequently associated with mucosal HPV-type infection, in particular HPV-6 and 11, and characterized by the growth of squamous papilloma in the airway epithelium [ 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

HPV-related diseases in male patients: an underestimated conundrum

Garolla,

Graziani,

Grande

et al. 2023

J Endocrinol Invest

View full text Add to dashboard Cite

Purpose Human papillomavirus (HPV) infection is the most common sexually transmitted disease, in males and females worldwide. While the role of HPV in female diseases is well known and largely studied, males have negligibly been included in these programs, also because the proportion of women suffering and dying from HPV-related diseases is much larger than men. The aim of this review is to focus on HPV-related diseases in male patients. Methods We performed a literature analysis on the electronic database PubMed. We considered randomized trials, observational and retrospective studies, original articles having as topic the relationship between HPV male infection and the following items: oral, anal penile cancers, warts, condylomas, male infertility, altered sperm parameters, anti-sperm antibodies (ASA). We also included experimental in vitro studies focused on the effects of HPV infection on oocyte fertilization, blastocyst development, and trophoblastic cell invasiveness. In addition, studies describing the adjuvant administration of the HPV vaccination as a possible strategy to promote HPV clearance from semen in infected males were included. Results Regarding head and neck HPV-related diseases, the most important non-neoplastic disease is recurrent respiratory papillomatosis (RRP). Regarding neoplastic diseases, the proportion of head and neck cancers attributable to HPV has increased dramatically worldwide. In addition, nowadays, it is thought that half of head and neck squamous cell carcinomas (HNSCCs) cases in the United States are caused by infection with high-risk HPV. HPV is noteworthy in andrological practice too. It was described as having a high HPV prevalence, ranging between 50 and 70%, in male penile shaft, glans penis/coronal sulcus, semen as well as in scrotal, perianal, and anal regions. Moreover, in male patients, HPV infection has been associated, among other diseases, with penile cancers. HPV semen infection has been reported in about 10% in men from the general population and about 16% in men with unexplained infertility, although these data seem widely underestimated according to clinical experience. In particular, HPV semen infection seems to be most related to asthenozoospermia and to anti-sperm antibodies (ASAs). Conclusions HPV infection represents a health problem with a detrimental social and public impact. Despite this evidence, little has been done to date to widely promote vaccination among young males.

show abstract

“…However, recent reports have detected alpha, beta, and gamma types in oral samples [ 2 ], cervical cancers [ 3 ], head and neck cancers [ 4 ], anal and genital areas of males [ 5 ], and juvenile-onset recurrent respiratory papillomatosis (JoRRP) [ 6 ]. In addition, interactions between HPV types in different genera may have biologic and clinical significance, as reported for the differential interaction of HPV16 with beta and gamma HPVs in head and neck cancers [ 7 ], the association of alpha and beta HPV coinfection with the clinical severity of JoRRP [ 6 ], and the detection of a high diversity of alpha, beta, and gamma HPVs in penile samples from males infected with HIV [ 8 ]. Mechanistic studies suggest that some beta 3 types, such as HPV49, 75, and 76, can immortalize primary keratinocytes such as those immortalized with high-risk alpha HPV16 [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Broad-Spectrum Detection of HPV in Male Genital Samples Using Target-Enriched Whole-Genome Sequencing

Li,

Unger,

Rajeevan

2023

Viruses

View full text Add to dashboard Cite

Most human papillomavirus (HPV) surveillance studies target 30–50 of the more than 200 known types. We applied our recently described enriched whole-genome sequencing (eWGS) assay to demonstrate the impact of detecting all known and novel HPV types in male genital samples (n = 50). HPV was detected in nearly all (82%) samples, (mean number of types/samples 13.6; range 1–85), and nearly all HPV-positive samples included types in multiple genera (88%). A total of 560 HPV detections (237 unique HPV types: 46 alpha, 55 beta, 135 gamma, and 1 mu types) were made. The most frequently detected HPV types were alpha (HPV90, 43, and 74), beta (HPV115, 195, and 120), and gamma (HPV134, mSD2, and HPV50). High-risk alpha types (HPV16, 18, 31, 39, 52, and 58) were not common. A novel gamma type was identified (now officially HPV229) along with 90 unclassified types. This pilot study demonstrates the utility of the eWGS assay for broad-spectrum type detection and suggests a significantly higher type diversity in males compared to females that warrants further study.

show abstract

Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

Cited by 7 publications

References 28 publications

Analysis of the anatomical distribution of HPV genotypes in head and neck squamous papillomas

Analysis of the anatomical distribution of HPV genotypes in head and neck squamous papillomas

HPV-related diseases in male patients: an underestimated conundrum

Broad-Spectrum Detection of HPV in Male Genital Samples Using Target-Enriched Whole-Genome Sequencing

Contact Info

Product

Resources

About