Clinical Implications of Early Mitral Regurgitation in Patients With Reperfused Acute Myocardial Infarction

Carrabba, Nazario; Parodi, Guido; Valenti, Renato; Shehu, Merita; Migliorini, Angela; Memisha, Gentian; Santoro, Giovanni Maria; Antoniucci, David

doi:10.1016/j.cardfail.2007.08.005

Cited by 20 publications

(15 citation statements)

References 34 publications

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“…Amigoni et al [23] in 496 patients with left ventricular dysfunction during acute MI, demonstrated correlation between the grade of MR and end-diastolic or end-systolic left ventricular volumes, increased sphericity index and decreased LVEF at 1 year. Carrabba et al [17], similar to our results, showed that higher grade of ischemic MR assessed by ERO was an independent predictor of remodeling. In contrast, Ennezata et al [24] did not confirm that MR at discharge is a predictor of remodeling at 1 year but MR assessments at 3 months were able to predict.…”

Section: Discussionsupporting

confidence: 91%

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Predictive value of ischemic mitral regurgitation during the acute phase of ST elevation myocardial infarction treated with primary coronary intervention for left ventricular remodeling in long-term follow-up

Wita

Berger-Kucza²,

Filipecki³

et al. 2010

Coronary Artery Disease

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Section: Discussionsupporting

confidence: 91%

“…Left ventricle dyssynchrony degree analyzed by Mollem et al [16] was found to predict remodeling. Carrabba et al [17] found that lower LVEF, lower LVEDV, and larger ERO at discharge and higher CKMB were independent predictors of remodeling in 184 patients with acute MI.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of ischemic mitral regurgitation during the acute phase of ST elevation myocardial infarction treated with primary coronary intervention for left ventricular remodeling in long-term follow-up

Wita

Berger-Kucza²,

Filipecki³

et al. 2010

Coronary Artery Disease

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“…Annuloplasty is used in later stages of functional ischemic MR and seems to improve the prognosis in patients with end-diastolic left ventricular diameter < 65 mm [10]. Based on many reports ischemic MR is an independent and important risk factor of progressive adverse left ventricular remodeling and heart failure and therefore any patient after myocardial infarction should undergo periodic echocardiographic examinations targeted also at the assessment of MR and its dynamic component [4,5,11,12]. Pharmacological treatment of MR is based on the use of angiotensin-converting enzyme inhibitors and β-blockers [13].…”

Section: Discussionmentioning

confidence: 99%

Myocardial infarction complicated by acute severe mitral regurgitation and cardiogenic shock. The importance of effective intra-aortic balloon pump therapy. A

Krynicki¹,

Sobocińska²

2012

pwki

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A b s t r a c tSevere functional mitral regurgitation in acute myocardial infarction may be one of the main reasons for cardiogenic shock. According to data from the SHOCK registry, this happens in 6.9% of cases of acute myocardial infarction complicated by heart failure. The only way to significantly improve the prognosis is the use of intra-aortic balloon pump (IABP) and urgent coronary revascularization. We describe a patient with acute myocardial infarction without ST-segment elevation, complicated by severe mitral regurgitation, successfully treated with IABP and percutaneous coronary intervention of the infarct-related coronary artery.K Ke ey y w wo or rd ds s: : myocardial infarction, cardiogenic shock, mitral regurgitation S t r e s z c z e n i e Duża czynnościowa niedomykalność zastawki mitralnej (mitral regurgitation -MR) w świeżym zawale serca (myocardial infarction -MI) może być jednym z zasadniczych powodów wstrząsu kardiogennego (cardiogenic shock -CS). Według danych rejestru SHOCK zdarza się to w około 7% przypadków zawału powikłanego ostrą niewydolnością serca. Podobnie jak w każdej innej przyczynie CS wikłającego MI, jedynie zastosowanie balonu kontrapulsacyjnego (intra-aortic balloon pump -IABP) i wczesna rewaskularyzacja wieńcowa przynoszą największą korzyść choremu, gdyż zwiększają szanse przeżycia. Przedstawiono przypadek pacjenta z zawałem serca bez uniesienia odcinka ST powikłanym ciężką MR, skutecznie leczonego IABP i plastyką tętnicy wieńcowej odpowiedzialnej za zawał serca. S Sł ło ow wa a k kl lu uc cz zo ow we e: : zawał serca, wstrząs kardiogenny, niedomykalność mitralna Corresponding author/Adres do korespondencji: Romuald Krynicki MD, PhD, Department of Cardiology, Hospital, 11 Piłsudski St, 18-400 Lomza, Poland, tel./fax: +48 86 47 33 265, e-mail: a.s@kardiologia-lomza.pl P Pr ra ac ca a w wp pł ły yn nę ęł ła a: : 28.07.2012, p pr rz zy yj ję ęt ta a d do o d dr ru uk ku u: : 13.09.2012. Case report/Opis przypadku IntroductionSevere functional mitral regurgitation (MR) complicating myocardial infarction (MI) may be one of the leading causes of cardiogenic shock (CS). According to data from the SHOCK registry it occurs in approximately 7% of cases of MI complicated by acute heart failure [1]. As in other causes of CS complicating acute myocardial infarction, intra-aortic balloon pump (IABP) and early percutaneous coronary intervention (PCI) are the sole strategies bringing significant benefits to the patient and increasing the chance of survival [2].We describe a case of a patient with non-ST-segment elevation MI complicated by severe MR successfully treated with IABP and PCI of the right coronary artery, which was the infarct-related artery. Case report

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“…As the size of the ageing population continues to increase, age‐related ischaemic heart diseases have become a primary contributor to mortality . Current treatments such as percutaneous coronary intervention or coronary artery bypass grafting have improved patients’ quality of life; however, long‐term cardiac function and survival in aged patients remain poor.…”

Section: Introductionmentioning

confidence: 99%

Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases

Zhang

et al. 2018

J Cellular Molecular Medi

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Sirtuin3 (SIRT3) is associated with oxidative stress and lifespan. However, the possible mechanisms underlying its influence are unknown. We hypothesized that SIRT3 increases the antioxidant capacity of aged cells and improves the efficacy of human mesenchymal stem cell (hMSC) therapy for ischaemic heart diseases in aged patients. In vitro, the antioxidant capacity of old hMSCs (O‐hMSCs) was increased after SIRT3 overexpression using a gene transfection technique, while the antioxidant capacity of young hMSCs (Y‐hMSCs) was decreased by SIRT3 silencing. The levels of forkhead box O3a (FoxO3a) in the nucleus, and antioxidant enzymes Mn‐superoxide dismutase (MnSOD) and catalase (CAT) increased in SIRT3‐overexpressed O‐hMSCs while they decreased in SIRT3‐silenced Y‐hMSCs after oxidative stress. Following myocardial infarction in adult rats in vivo, infarct size decreased and cardiac function was significantly enhanced after cell transplantation with SIRT3 overexpressed O‐hMSCs. The number of apoptotic cells decreased and the survival rate of transplanted cells increased following SIRT3 overexpression in O‐hMSCs. SIRT3 protects aged hMSCs against oxidative stress by positively regulating antioxidant enzymes (MnSOD and CAT) via increasing the expression of FoxO3a in the nucleus. The efficacy of aged hMSC transplantation therapy for ischaemic heart diseases can be improved by SIRT3 overexpression.

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Clinical Implications of Early Mitral Regurgitation in Patients With Reperfused Acute Myocardial Infarction

Cited by 20 publications

References 34 publications

Predictive value of ischemic mitral regurgitation during the acute phase of ST elevation myocardial infarction treated with primary coronary intervention for left ventricular remodeling in long-term follow-up

Predictive value of ischemic mitral regurgitation during the acute phase of ST elevation myocardial infarction treated with primary coronary intervention for left ventricular remodeling in long-term follow-up

Myocardial infarction complicated by acute severe mitral regurgitation and cardiogenic shock. The importance of effective intra-aortic balloon pump therapy. A

Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases

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