Clinical implications of hypermucoviscosity phenotype in <i>Klebsiella pneumoniae</i> isolates: association with invasive syndrome in patients with community‐acquired bacteraemia

Lee, Hsin Chun; Chuang, Yin Ching; Yu, Wen-Liang; Lee, Nan Yao; Chang, Chia Ming; Ko, Nai Ying; Wang, Li Rong; Ko, Wen Chien

doi:10.1111/j.1365-2796.2006.01641.x

Cited by 201 publications

(161 citation statements)

References 29 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…Colonized fluids included tracheal secretions, urine and superficial secretions. Factors leading from colonization to infection are not well understood [8]. The presence of hvKP in the urine may be a potential marker for bacteremia [18].…”

Section: Discussionmentioning

confidence: 99%

“…hvKP is considered to be more virulent than hv-negative strains and this phenotype is commonly found in K. pneumoniae strains which cause CA-PLA and BSI [8,12,13]. More importantly, they exhibit a higher tendency to metastatic spread.…”

Section: Introductionmentioning

confidence: 99%

“…Life-threatening liver abscesses, pneumonia, meningitis, bloodstream infections (BSI) or endophthalmitis caused by hvKP have been increasingly reported in the USA, Brazil, Germany, Japan, and Australia [2][3][4][5][6]. These infections are often community-acquired [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids

Xiao

Yao

Zhou

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Reports of hypermucoviscous Klebsiella pneumoniae (hvKP) isolated from fluids other than blood or abscess are rare. The aim of the study was to compare clinical and microbiological characteristics of hvKP found in blood or abscess fluid with those isolated from other loci. Methodology: A total of 24 non-repetitive hvKP isolates were collected from January 2013 to June 2014 from patients with hvKP infections. There were 15 in Group 1 (fluid other than blood or abscess) and 9 in Group 2 (blood or abscess fluid). Medical records of all patients were reviewed. Capsular polysaccharide (CPS) typing, virulence factor determination, and multilocus sequence typing (MLST) of hvKP isolates were performed. Results: Seventeen sequence types (STs) and 6 capsular serotypes were identified. Type K2 CC65 was most commonly identified in Group 1 and type K2 CC86 in Group 2. Deletion of pLVPK-derived loci were found in K2 and non-K1/K2 hvKP strains. Two virulent genes, fimH and ycfM, were identified more frequently in Group 2 than in Group 1. There was no difference in the frequency of other virulent genes or serotypes in the two groups. Two imipenem resistant hvKP isolates (cr-hvKP) were found in non-blood or abscess samples. Conclusions: hvKP isolated from different body fluids had similar clinical and microbiological characteristics. cr-hvKP identified in non-blood or abscess samples should raise our attention to the challenging situation and management of hvKP infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids

Xiao

Yao

Zhou

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Capsular K1 serotype is a significant virulence determinant for the development of septic ocular and central nervous system complications from PLA [10]. Furthermore a number of clinical studies pointed to a relationship between the hypermucoviscosity phenotype of Klebsiella pneumoniae and the presence of an invasive disease with metastatic infection [11]. Klebsiella pneumoniae strains possess the hypermucosviscosity phenotype if they are capable of producing a mucoviscous exopolysaccharide web.…”

Section: Discussionmentioning

confidence: 99%

Liver abscess caused by Klebsiella pneumoniae: two case reports

et al. 2009

View full text Add to dashboard Cite

show abstract

“…pneumoniae has been reported to be the most common pathogen causing liver abscess in Korea [6,7]. The incidence of K. pneumoniae infection increases in immunocompromised conditions, such as diabetes mellitus, alcoholism, malignancy, hepatobiliary disease, chronic obstructive pulmonary disease, glucocorticoid therapy and renal failure [6][7][8][9][10][11][12][13][14]. In our case, the In a few cases, K. pneumoniae liver abscess has been associated with metastatic infection at other sites [7,8,[10][11][12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Emphysematous prostatitis combined with a liver abscess caused byKlebsiella pneumoniae

et al. 2011

View full text Add to dashboard Cite

Emphysematous prostatitis combined with a liver ab scess caused by Klebsiella pneumoniae Emphysematous prostatitis is a rare condition that is characterized by gas and abscess accumulation in the prostate. This uncommon but serious disease requires special attention because of its nonspecific presentation such as dysuria, frequency, urgency, fever, acute urinary retension and/or perineal pain. We report here on a case of emphysematous prostatitis that was combined with a liver abscess caused by Klebsiella pneumoniae. A 55yearold man was admitted due to a 3day history of urinary retention with a febrile sensation. He had histories of liver cirrhosis and uncontrolled diabetes mellitus. After blood and urine cultures, levofloxacin 500 mg was started intravenously. On the third hospital day, he displayed septic shock.The kidneysureters bladder (KUB) Xray showed pockets of airaccumulation in the lower pelvic cavity, and abdominopelvic computed tomography (CT) with contrast enhancement taken on the third day showed a 5cm liver abscess with an emphysematous prostate. Intravenous antibiotics was changed to metronidazole 500 mg q.i.d. and cefotaxime 2 g t.i.d. On the sixth day, transurethral resection and drainage were performed under spinal anesthesia. However, the postoperative bleeding continued and hypovolemic shock persisted, which then provoked multiorgan failure. The patient died on the 11th hospital day. K. pneumoniae was cultured from the liver abscess aspirate, blood and prostatic tissue, and the bacteria were sensitive to both levofloxacin and cefotaxime. Emphysematous prostatitis is a difficult to diagnose because of its rarity and nonspecific symptoms. A delayed diagnosis can cause high mortality and morbidity, so making a prompt clinical diagnosis of this condition is essential. Appropriate antibiotics with early adequate incision and drainage are also needed.

show abstract

Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community‐acquired bacteraemia

Cited by 201 publications

References 29 publications

Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids

Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids

Liver abscess caused by Klebsiella pneumoniae: two case reports

Emphysematous prostatitis combined with a liver abscess caused byKlebsiella pneumoniae

Contact Info

Product

Resources

About