Clinical Implications of Naples Prognostic Score in Patients with Resected Pancreatic Cancer

Nakagawa, Nobuhiko; Yamada, Suguru; Sonohara, Fuminori; Takami, Hideki; Hayashi, Masamichi; Kanda, Mitsuro; Kobayashi, Daisuke; Tanaka, Chie; Nakayama, Goro; Koike, Masahiko; Fujiwara, Michitaka; Kodera, Yasuhiro

doi:10.1245/s10434-019-08047-7

Cited by 60 publications

(56 citation statements)

References 28 publications

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“…Nutritional and immune status has been proven to correlate with therapeutic effects and long-term prognosis in various tumors, including osteosarcoma. 5,6,20,47 A series of nutrition-and immune-based indices or scoring systems were developed and utilized as prognostic predictors, 6,[48][49][50][51] with the CONUT score being the most commonly used one among them. As an immune-nutritional marker, CONUT score has included the information of serum levels of albumin, cholesterol, and TLC.…”

Section: Discussionmentioning

confidence: 99%

<p>CONUT Score or/and Peripheral Blood CD4+/CD8+ Ratio-Based Web Dynamic Nomograms to Predict the Individualized Survival of Patients with Advanced Osteosarcoma</p>

Yang

Wang

et al. 2020

CMAR

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Background: Nutritional and immune status is paramount for the overall survival (OS) of patients with advanced osteosarcoma. Comprehensive prognostic predictors based on the two indices are scarce. This study aimed to construct and validate individualized web dynamic nomograms based on CONUT score or/and peripheral blood CD4+/CD8+ ratio for OS in patients with advanced osteosarcoma. Materials and Methods: The clinical data of 376 advanced osteosarcoma patients from January 2000 to December 2019 were retrospectively collected. Data from the 301 patients (diagnosed in the first 15 years) were used as the development set and data from the remaining 75 patients were assigned as the validation set. Multivariate Cox regression analyses were conducted and three prediction models were constructed, namely, CD4 +/CD8+ ratio univariate model (model 1), CONUT score univariate model (model 2), and CD4+/CD8+ ratio plus CONUT score (model 3). These models were visualized by conventional nomograms and individualized web dynamic nomograms, and their performances were further evaluated by C-index, calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA), respectively. Results: In multivariate Cox analysis, age, metastasis, ALP, CD4+/CD8+ ratio, chemotherapy, and CONUT score were identified as independent prognostic factors for OS. The calibration curves of the three models all showed good agreement between the actual observation and nomogram prediction for 1-year overall survival. In the development set, the C-index and area under the curve (AUC) of model 3 (0.837, 0.848) were higher than that of model 1 (0.765, 0.773) and model 2 (0.712, 0.749). Similar trends were observed in the validation set. The net benefits of model 3 were better than the other two models within the threshold probability of 36-80% in DCA. Conclusion: CONUT score and peripheral CD4+/CD8+ ratio are easily available, reliable, and economical prognostic predictors for survival prediction and stratification in patients with advanced osteosarcoma, but the two predictors combined can establish a better prognosis prediction model.

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Section: Discussionmentioning

confidence: 99%

<p>CONUT Score or/and Peripheral Blood CD4+/CD8+ Ratio-Based Web Dynamic Nomograms to Predict the Individualized Survival of Patients with Advanced Osteosarcoma</p>

Yang

Wang

et al. 2020

CMAR

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“…Growing evidence indicates that the inflammatory reaction in microenvironment contributes to tumor progression, including the induction of angiogenesis, tumor cell proliferation and TC level, LMR together with NLR, is a novel inflammation-based prognostic score. Researchers have identified that NPS has prognostic value for pancreatic cancer, CRC and osteosarcoma (13,14,16). It takes into account the effects of both nutritional status and systemic inflammation on tumor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Galizia et al first reported that the Naples prognostic score (NPS) was the novel rating system formulated according to serum Alb level, total cholesterol (TC) level, NLR along with LMR, which reflected the nutritional and systemic inflammatory statuses in cancer patients (13). Typically, the NPS is strongly associated with the prognostic outcomes for colorectal cancer (CRC), pancreatic cancer, lung cancer, gastric cancer, and osteosarcoma (13)(14)(15)(16)(17). Additionally, studies have shown that the NPS is more accurate than other prognostic factors in predicting survival (13,14,18).…”

Section: Introductionmentioning

confidence: 99%

“…Typically, the NPS is strongly associated with the prognostic outcomes for colorectal cancer (CRC), pancreatic cancer, lung cancer, gastric cancer, and osteosarcoma (13)(14)(15)(16)(17). Additionally, studies have shown that the NPS is more accurate than other prognostic factors in predicting survival (13,14,18). So far, few researches has been carried out to examine the role of NPS in predicting the prognosis for AEJ cases receiving surgical resection.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

et al. 2020

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BackgroundThe naples prognostic score (NPS) is established according to nutritional or inflammatory state, and it is identified as the new prognostic score for a variety of malignant tumors. However, its significance in cases suffering from adenocarcinoma of esophagogastric junction (AEJ) who receive surgery remains unclear so far.MethodsIn this study, patients receiving surgery without preoperative therapy were examined between June 2007 and August 2017 in a retrospective way. Typically, the serum albumin level, total cholesterol level, neutrophil-to-lymphocyte ratio, together with the lymphocyte-to-monocyte ratio, was determined to calculate the NPS. The prognostic impact of NPS was evaluated using survival analyses. Time-dependent receiver operating characteristic curve (t-ROC) analysis was also carried out for comparing prognostic impacts of those scoring systems.ResultsAltogether 231 cases were enrolled in this study. A higher NPS showed positive correlation with perineural invasion. Upon multivariate analysis, NPS was identified to be the independent prognostic factor to predict overall survival (OS) along with relapse-free survival (RFS) (both P< 0.05), and an especially strong correlation was observed at advanced pTNM stages based on NPS system. As for subgroup analyses on adjuvant chemotherapy or surgery only, NPS still independently predicted the OS as well as RFS (both P< 0.05) in both groups. Furthermore, t-ROC analysis showed that NPS was more accurate than the systemic inflammation score in predicting OS and RFS.ConclusionsThe NPS represents the simple and useful rating system, which can independently predict the survival for AEJ cases undergoing surgery.

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“…Recently, an increasing number of studies report that NPS, which is established based on the preoperative total cholesterol (TC) content, serum albumin (Alb) content, LMR and NLR, represents a new inflammation-related prognostic scoring system. Researchers have demonstrated that NPS shows prognostic value for pancreatic cancer, colorectal cancer (CRC), lung cancer and osteosarcoma (9)(10)(11). Besides, NPS is more accurate than other prognostic factors in predicting survival (9,10,12).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Impact of Preoperative Naples Prognostic Score in Gastric Cancer Patients Undergoing Surgery

Xiong

Kang

et al. 2021

Front. Surg.

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Background: The Naples prognostic score (NPS) is established according to nutritional or inflammatory state, which has been identified as a new prognostic score for various malignant tumors. However, its prognosis prediction effect on gastric cancer (GC) patients is still unknown so far. The present work aimed to examine the NPS function in the prediction of GC prognosis.Methods: In this study, patients undergoing surgery with no preoperative therapy were retrospectively examined from June 2011 to August 2019. Typically, the total cholesterol level, serum albumin content, neutrophil-to-lymphocyte ratio and lymphocyte-to-monocyte ratio were determined to calculate the NPS. Besides, the prognostic value of NPS was evaluated by survival analyses. Time-dependent receiver operating characteristic (t-ROC) curve analysis was also carried out to compare the prognostic value of the scoring systems.Results: Altogether 1,283 cases were enrolled into the present work. NPS was markedly related to age, gender, tumor size, body mass index, vascular invasion, perineural invasion, and pTNM stage. Upon multivariate analysis, NPS was identified as an independent prognostic factor for the prediction of overall survival (OS) (P < 0.001). In subgroup analyses stratified by adjuvant chemotherapy or surgery alone, NPS was still the independent prognostic factor for OS in both groups (both P < 0.001). Furthermore, NPS exhibited higher accuracy in the prediction of OS than additional prognostic factors, as revealed by the results of t-ROC curve analysis.Conclusions: NPS is a simple and useful scoring system that can be used to independently predict the survival of GC cases undergoing surgery.

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Clinical Implications of Naples Prognostic Score in Patients with Resected Pancreatic Cancer

Cited by 60 publications

References 28 publications

<p>CONUT Score or/and Peripheral Blood CD4+/CD8+ Ratio-Based Web Dynamic Nomograms to Predict the Individualized Survival of Patients with Advanced Osteosarcoma</p>

<p>CONUT Score or/and Peripheral Blood CD4+/CD8+ Ratio-Based Web Dynamic Nomograms to Predict the Individualized Survival of Patients with Advanced Osteosarcoma</p>

Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

Prognostic Impact of Preoperative Naples Prognostic Score in Gastric Cancer Patients Undergoing Surgery

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