Clinical implications of serum adiponectin on progression of atrial fibrillation

Yamaguchi, Naoko; Okumura, Yasuo; Watanabe, Ichiro; Nagashima, Koichi; Takahashi, K.; Iso, Kazuki; Watanabe, Ryuta; Arai, M.; Kurokawa, Syuhei; Ohkubo, Kimie; Nakai, Toshiko; Hirayama, Atsushi

doi:10.1016/j.joa.2017.07.009

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Another study, included patients who underwent catheter ablation for AF, found similar results [14]. These studies showed that adiponectin elevation was associated with AF recurrence independent of LA volume and LVEF [1,14].…”

Section: Discussionmentioning

confidence: 69%

“…Adiponectin is a peptide hormone with insulin-sensitizing, anti-inflammatory, and anti-atherosclerotic effects, and it is presumed to be protective against cardio vascular (CV) diseases [1]. However, elevated adiponectin concentration is associated with adverse CV outcomes, including coronary heart disease, heart failure, and allcause mortality.…”

Section: Introductionmentioning

confidence: 99%

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Is Adiponectin Elevation Associated with Left Atrial Remodeling and Impaired Mechanical Functions? (a Speckle Tracking Study)

Kalaycıoğlu¹,

Çetin

Özyıldız

et al. 2021

Kardiologiia

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Objectives Recent studies demonstrated that elevated adiponectin levels predicted an increased risk of atrial fibrillation (AF) and stroke; however, a causal relationship is yet to be unknown. Reduced left atrium (LA) functions detected by two-dimensional echocardiographic speckle tracking (2D-STE) can predict AF development. We aimed to investigate the relationship between adiponectin level and LA functions in hypertensive and diabetic patients at high risk for incident AF.Material and methods The study consisted of 80 hypertensive diabetic patients. All patients underwent echocardiography, and venous blood samples were taken. The relationship between adiponectin levels and LA functions was analyzed.Results We divided patients into two groups according to the mean adiponectin level (13.63 ng / ml). In the high adiponectin group, the mean age (p=0.001) and high-density lipoprotein (HDL) cholesterol (p=0.015) were higher, whereas estimated glomerular filtration rate (eGFR) (p=0.036) and hemoglobin (p=0.014) levels were lower. Although LA maximum volume, LA minimum volume, and LA pre-A volume were higher in the group with high adiponectin levels, they did not reach a statistical significance. Peak early diastolic LA strain (S-LAe) (p=0.048) and strain rate (SR-LAe) (p=0.017) were lower in this group. Multivariate logistic regression analysis demonstrated that age (p=0.003) and hemoglobin (p=0.006) were predictors of elevated adiponectin levels. On the contrary, S-LAe, HDL cholesterol, and eGFR lost their statistical significance.Conclusion In patients with HT and DM, elevated adiponectin level is associated with impaired LA mechanical functions. Increased age and hemoglobin level are independent predictors of elevated adiponectin levels.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Is Adiponectin Elevation Associated with Left Atrial Remodeling and Impaired Mechanical Functions? (a Speckle Tracking Study)

Kalaycıoğlu¹,

Çetin

Özyıldız

et al. 2021

Kardiologiia

View full text Add to dashboard Cite

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Adeponectin gene polymorphism, rs2241766, is associated with coronary artery disease in Iraqi population

et al. 2019

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Epicardial fat and atrial fibrillation: the perils of atrial failure

et al. 2022

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Obesity is a heterogeneous condition, characterized by different phenotypes and for which the classical assessment with body mass index may underestimate the real impact on cardiovascular (CV) disease burden. An epidemiological link between obesity and atrial fibrillation (AF) has been clearly demonstrated and becomes even more tight when ectopic (i.e. epicardial) fat deposition is considered. Due to anatomical and functional features, a tight paracrine cross-talk exists between epicardial adipose tissue (EAT) and myocardium, including the left atrium (LA). Alongside—and even without—mechanical atrial stretch, the dysfunctional EAT may determine a pro-inflammatory environment in the surrounding myocardial tissue. This evidence has provided a new intriguing pathophysiological link with AF, which in turn is no longer considered a single entity but rather the final stage of atrial remodelling. This maladaptive process would indeed include structural, electric, and autonomic derangement that ultimately leads to overt disease. Here, we update how dysfunctional EAT would orchestrate LA remodelling. Maladaptive changes sustained by dysfunctional EAT are driven by a pro-inflammatory and pro-fibrotic secretome that alters the sinoatrial microenvironment. Structural (e.g. fibro-fatty infiltration) and cellular (e.g. mitochondrial uncoupling, sarcoplasmic reticulum fragmentation, and cellular protein quantity/localization) changes then determine an electrophysiological remodelling that also involves the autonomic nervous system. Finally, we summarize how EAT dysfunction may fit with the standard guidelines for AF. Lastly, we focus on the potential benefit of weight loss and different classes of CV drugs on EAT dysfunction, LA remodelling, and ultimately AF onset and recurrence.

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Clinical implications of serum adiponectin on progression of atrial fibrillation

Cited by 3 publications

References 22 publications

Is Adiponectin Elevation Associated with Left Atrial Remodeling and Impaired Mechanical Functions? (a Speckle Tracking Study)

Is Adiponectin Elevation Associated with Left Atrial Remodeling and Impaired Mechanical Functions? (a Speckle Tracking Study)

Adeponectin gene polymorphism, rs2241766, is associated with coronary artery disease in Iraqi population

Epicardial fat and atrial fibrillation: the perils of atrial failure

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