Clinical implications of serum <scp><i>Wisteria floribunda</i></scp> agglutinin‐positive Mac‐2‐binding protein in treatment‐naïve chronic hepatitis B

Ishii, Akio; Nishikawa, Hiroki; Enomoto, Hirayuki; Iwata, Yoshinori; Kishino, Kyohei; Shimono, Yoshihiro; Hasegawa, Kunihiro; Nakano, Chikage; Takata, Ryo; Nishimura, Takashi; Yoh, Kazunori; Aizawa, Nobuhiro; Sakai, Yoshiyuki; Ikeda, Naoto; Takashima, Tomoyuki; Iijima, Hiroko; Nishiguchi, Shuhei

doi:10.1111/hepr.12703

Cited by 43 publications

(65 citation statements)

References 33 publications

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“…Thus, 21 studies ware included in the final analysis. Characteristics of these studies are shown in Table . All studies were published between January 2013 and September 2016.…”

Section: Resultsmentioning

confidence: 99%

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein levels and liver fibrosis: A meta‐analysis

Ito

Murotani

Nakade

et al. 2017

J of Gastro and Hepatol

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“…Thus, 21 studies ware included in the final analysis. Characteristics of these studies are shown in Table . All studies were published between January 2013 and September 2016.…”

Section: Resultsmentioning

confidence: 99%

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein levels and liver fibrosis: A meta‐analysis

Ito

Murotani

Nakade

et al. 2017

J of Gastro and Hepatol

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“…[24] Liver fibrosis stages were graded as F0 to F4 by expert pathologists in our hospital. In the present study, we defined advanced fibrosis as F3 or more, and no patients had ascites as noted in imaging studies.…”

Section: Methodsmentioning

confidence: 99%

“…Detection of HBs antigen and HBe antigen and measurement of HBV-DNA level were performed using commercial kits as formerly described. [24] We measured WFA + -M2BP level using stored sera. The method for measurement of WFA + -M2BP level was as described elsewhere.…”

Section: Methodsmentioning

confidence: 99%

A proposed predictive model for advanced fibrosis in patients with chronic hepatitis B and its validation

Nishikawa

Hasegawa²,

Ishii³

et al. 2016

Medicine

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We created a predictive model using serum-based biomarkers for advanced fibrosis (F3 or more) in patients with chronic hepatitis B (CHB) and to confirm the accuracy in an independent cohort.A total of 249 CHB patients were analyzed. To achieve our study aim, a training group (n = 125) and a validation group (n = 124) were formed. In the training group, parameters related to the presence of advanced fibrosis in univariate and multivariate analyses were examined, and a formula for advanced fibrosis was created. Next, we verified the applicability of the predictive model in the validation group.Multivariate analysis identified that gamma-glutamyl transpeptidase (GGT, P = 0.0343) and platelet count (P = 0.0034) were significant predictors of the presence of advanced fibrosis, while Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP, P = 0.0741) and hyaluronic acid (P = 0.0916) tended to be significant factors. Using these 4 parameters, we created the following formula: GMPH score = −0.755 − (0.015 × GGT) − (0.268 × WFA+-M2BP) + (0.167 × platelet count) + (0.003 × hyaluronic acid). In 8 analyzed variables (WFA+-M2BP, aspartate aminotransferase-to-platelet ratio index, FIB-4 index, prothrombin time, platelet count, hyaluronic acid, Forns index, and GMPH score), GMPH score had the highest area under the receiver operating characteristic (AUROC) curve for advanced fibrosis with a value of 0.8064 in the training group and in the validation group, GMPH score also had the highest AUROC (0.7782). In all subgroup analyses of the hepatitis B virus (HBV) status (HB surface antigen quantification, HBV-DNA quantification, and HBe antigen seropositivity), GMPH score in F3 or F4 was significantly lower than that in F0 to F2. In the above mentioned 8 variables, differences between the liver fibrosis stages (F0 to F1 vs F2, F2 vs F3, F3 vs F4, F0 to F1 vs F3, F0 to F1 vs F4, and F2 vs F4) for the entire cohort (n = 249) were all significant only in GMPH score.In conclusion, the GMPH scoring system may be helpful for detecting advanced liver fibrosis in patients with CHB.

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“…This finding is well in line with recent reports from Japan. Ishii et al found that the median serum WFA+-M2BP level was 1.2 COI in treatment of naive chronic hepatitis B patients [28]. Ichikawa et al reported that serum WFA+-M2BP level was 0.97 COI in 112 treatment naive patients with HBV-related chronic hepatitis and liver cirrhosis [17].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

Cent Asian J Med Sci

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Objectives: Quantification of serum HBsAg has several clinical significances such as acting as a biomarker for the hepatitis D virus (HDV)-RNA level and necroinflammatory activity in HDV infection. The WFA+-M2BP is a new glyco-biomarker for liver fibrosis. The aim of this study was to compare the quantitative HBsAg and M2BPGi levels between groups of HBV infected patients with or without HDV infection. Methods: Totally, 112 consecutive HBsAg carriers with or without HDV infection (median age 36 vs 38) were enrolled in the study. Serum HBsAg and M2BPGi levels were measured using commercial tests. Results: Mean qHBsAg concentrations were 3.8 ±0.6 log IU/mL and 3.5 ±0.8 log IU/mL in the HDV positive and HDV negative HBsAg carriers, respectively (p = 0.02). Yet 45 patients out of 56 HDV positive patients have HBsAg level >2000 IU/mL whereas only 33 patients in the HBV mono infected group had concentrations this high. The mean M2BPGi was a 1.2 cut-off index (COI) in the HDV negative group vs. 2.1 COI in the HDV positive group (p <0.001). Conclusion: The qHBsAg level was higher in HDV positive patients compared with HDV negative subjects. But qHBsAg levels were higher in the HBeAg positive subjects despite the presence of HDV infection. The mean M2BPGi value in the HDV positive group was higher than in HDV negative subjects.

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Clinical implications of serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein in treatment‐naïve chronic hepatitis B

Abstract: The WFA -M2BP level can be a useful marker for assessing liver histological findings in patients with treatment-naïve CHB, although it has several limitations.

Cited by 43 publications

References 33 publications

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein levels and liver fibrosis: A meta‐analysis

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein levels and liver fibrosis: A meta‐analysis

A proposed predictive model for advanced fibrosis in patients with chronic hepatitis B and its validation

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