Clinical Implications of the Infratentorial Rosette-Forming Glioneuronal Tumor

Tan, Caroline C.; Gonzales, Michael; Veitch, Alastair

doi:10.1227/01.neu.0000335085.00718.92

Cited by 28 publications

(22 citation statements)

References 12 publications

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“…6) The presence of pilocytic astrocytes in the RGNT indicates a benign prognosis. 17) In the postoperative period, most resected lesions did not recur, although only biopsy was performed in three cases (Table 1). In addition, unresected satellite lesions in five patients revealed no evidence of progression for several years.…”

Section: Discussionmentioning

confidence: 97%

“…If the patient has no significant neurological symptoms related to the tumor, the only surgery that should be performed is a biopsy. 17) Radiotherapy is not indicated in most cases.…”

Section: Discussionmentioning

confidence: 99%

“…11) Only 19 further cases have been reported since the first series. 1,2,[7][8][9][10][11][12]14,15,17,18) We describe a case of RGNT and discuss the clinical features of this entity.…”

Section: Introductionmentioning

confidence: 99%

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Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle -Case Report-

Arai

Sasayama

Tamaki

et al. 2010

Neurol. Med. Chir.(Tokyo)

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Fig. 1 Computed tomography scans revealing a hypodense mass in the vermis (A), and no enhancement of the lesion in the fourth ventricle after the administration of contrast agent (B). 224Neurol Med Chir (Tokyo) 50, 224¿228, 2010 RGNT of the fourth ventricle should be considered in the differential diagnosis of infratentorial lesions in young adults. The prognosis is benign, but relatively aggressive behaviors such as tumor growth, recurrence, and acute deterioration due to intratumoral hemorrhaging can occur. Surgical resection requires care to prevent major surgical morbidities associated with lesions invading the cerebellum or brainstem.

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Section: Discussionmentioning

confidence: 97%

“…If the patient has no significant neurological symptoms related to the tumor, the only surgery that should be performed is a biopsy. 17) Radiotherapy is not indicated in most cases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle -Case Report-

Arai

Sasayama

Tamaki

et al. 2010

Neurol. Med. Chir.(Tokyo)

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“…Most common postoperative complications are ataxia, cranial nerve palsy (CN VI, VII) and diplopia. Cerebellar mutism has also been described in the literature (Tan, 2008;Li, 2009). …”

Section: Discussionmentioning

confidence: 94%

Aggressive Rosette Forming Glioneuroma: Case Report and Review of the Literature

Frelinghuysen¹,

Luna²,

Spencer³

et al. 2014

CCO

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We report the case of a patient who presented a pineal tumor. A partial resection was performed. The biopsy showed a glioneuroma rosette forming tumor, considered as WHO grade I. The patient was observed for 13 months and experienced significant tumor growth. Radiotherapy was performed. Instead of scarce evidence of the topic and treatment modalities in this type of tumors; radiotherapy was performed. The patient has been stable and asymptomatic.Keywords: pineal, tumor, partial, resection, radiotherapy IntroducationThe rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle tumor of the glioneuronal family (Komori, 2002). The clinical presentation, natural history, and treatment response of these tumors has been unclear as there are no significant series of a sizeable population with long-term follow-up (Solis, 2011;Marhold, 2008). Classically, has been described as WHO I grade neoplasms with indolent biologic behaviour. The optimal management is surgical resection, mainly in symptomatic patients cases where tumor is causing mass effect over neighboring structures (Zhang, 2013). Adjuvant treatments are supported by few data and their role is unknown. We present the case of a rosette forming glioneuroma tumor with aggressive behavior that doubled size after 16 months of follow up after partial resection achieving decompression of neural structures. Case ReportThe present case refers to a previously healthy 48 years old woman who began with mild headache for 2 weeks. Brain MRI showed an expansive cystic-solid heterogeneous contrast enhancement mass of 2,4 cm in the pineal region with mass effect over mesencephalon and cuadrigeminal plate. Tumor markers, including beta-human chorionic gonadotropin, and alpha-fetoprotein were not significantly elevated in both the cerebrospinal fluid (CSF). A partial resection of the tumor by endoscopic approach and III cisternoventriculostomy was approached because of thalamic invasion.The tumor specimen was analyzed by pathology department of Universidad de Concepcion and the case was consulted to neuropathologists of the MD Anderson cancer center. The final biopsy report was Rosette forming glioneuronal tumor, Ki67 negative, GFAP positive. The patient was evaluated then by an interdisciplinary oncology committee (neurosurgery, radiation oncology, pathology and medical oncology) and the management decision based on the evidence reported was observation, mainly due to the indolent behavior reported in the literature.

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“…Scheithauer et al [31] reported that periventricular germinal matrix is the likely origin of RGNTs and so, they may be occurring in "ectopic" sites. Rosette-forming glioneuronal tumours may be located in different areas such as the pineal region [9,10] and lateral ventricles [35] and some satellite tumours may also be seen in the patients [6,18,27,33].…”

Section: Discussionmentioning

confidence: 99%